ID A0A1B0BHD8_9MUSC Unreviewed; 1206 AA.
AC A0A1B0BHD8;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
OS Glossina palpalis gambiensis.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC Glossinidae; Glossina.
OX NCBI_TaxID=67801 {ECO:0000313|EnsemblMetazoa:GPPI030122-PA, ECO:0000313|Proteomes:UP000092460};
RN [1] {ECO:0000313|Proteomes:UP000092460}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IAEA {ECO:0000313|Proteomes:UP000092460};
RA Aksoy S., Warren W., Wilson R.K.;
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:GPPI030122-PA}
RP IDENTIFICATION.
RC STRAIN=IAEA {ECO:0000313|EnsemblMetazoa:GPPI030122-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
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DR EMBL; JXJN01014303; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; JXJN01014304; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A1B0BHD8; -.
DR STRING; 67801.A0A1B0BHD8; -.
DR EnsemblMetazoa; GPPI030122-RA; GPPI030122-PA; GPPI030122.
DR VEuPathDB; VectorBase:GPPI030122; -.
DR Proteomes; UP000092460; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR GO; GO:0048666; P:neuron development; IEA:UniProt.
DR CDD; cd00063; FN3; 4.
DR CDD; cd14553; R-PTPc-LAR-1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF7; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR Pfam; PF00041; fn3; 4.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 4.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 556..579
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..85
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 90..183
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 187..280
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 282..384
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 651..906
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 823..897
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 938..1197
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1115..1188
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 524..547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 524..538
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1206 AA; 138579 MW; 3C58FBCBA0A9C43F CRC64;
MERDPTVSIE LEWERPAQTY GELRGYRLRW GVKDRALKEL LMGPHETKKP FKDLERGVEY
EFRIAGSNHI GIGQETVKIF QTPEGVPGGP PSNITVRFQT PDVVCVTWEP PTREHRNGII
TRYDVQFHKK IDHGLGSERN MTLRKAVFTN LEENTEYIFR VRAYTKQGAG PFSEKILIET
ERDMGRAPMS VQAVATSEQT AEIWWEPVPS RGKLLGYKIF YTMTAVEDLD EWQTKTVGLT
ESADLVNLEK FAQYAVAIAA RFKNGLGRLS EKVTVKIKPE DVPLNLRAHD VTTHSMTLSW
SPPIRLNPIN YKISYDAMKV FVDSQGFSQT QIVQKRDIIL KAYAKSHTIN ELSPFTTYNV
NVSAIPSDYS YRPPTKITVT TQMAAPQPMV KPDFYGVVNG EEILVILPQA SEEYGPISHY
YLVVVPEDKS NLHKNPDQFL TEDLLPGRNK PERPNAPYIA AKFPQRSIPF TFHLGSGDDY
HNFTNRKLER DKRYRIFVRA VVDTPQKHLY TSSPFSEFLS LDMREAPPGE RPHRPDPNWP
SEPEVSVNRN KDEPGMLWVV LPAIAALILS TTFIIIYVIK RRRQPCKTPD QAAVTRPLMA
ADLGAGPTPS DPVDMRRLNF QTPGMISHPP IPISEFANHI ERLKANDNQK FSQEYESIEP
GQQFTWDNSN YEYNKSKNRY ANVTAYDHSR VILPLTDGVV GSDYINANYC DGYRKHNAYV
ATQGPLQETI GDFWRMCWEL KTATIVMMTR LEERTRIKCD QYWPTRGTET YGQMFVTITE
TQELATYSIR TFQLCRQGFN ERREIKQLQF TAWPDHGVPD HPAPFLQFLR RCRALTPPDS
GPIIVHCSAG VGRTGCYIVI DSMLERMKHE KIVDIYGHVT CLRAQRNYMV QTEDQYIFIH
DAILEAIICG HTEVPARNLH THLQKLLTTE PGENITGMEI EFKKLSNVKV DSSKFVTANL
PCNKHKNRLV HILPYESTRV YLTPIHGIEG SDYINASFIE GYRYRSAYIA AQGPLQDTAE
DFWRMLWEHN STIVVMLTKL KEMGREKCFQ YWPHERSVRY QYYVVDPIAE YNMPQYKLRE
FKVTDARDGS SRTVRQFQFI DWPEQGVPKS GEGFIDFIGQ VHKTKEQFGQ DGPITVHCSA
GVGRTGVFIT LSIVLERMQY EGVLDVFQTV RILRAQRPAM VQTEDQYHFC YRAALEYLGS
FDNYTN
//