ID A0A1B0BHH4_9MUSC Unreviewed; 1131 AA.
AC A0A1B0BHH4;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Transient receptor ion channel domain-containing protein {ECO:0000259|SMART:SM01420};
OS Glossina palpalis gambiensis.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC Glossinidae; Glossina.
OX NCBI_TaxID=67801 {ECO:0000313|EnsemblMetazoa:GPPI030250-PA, ECO:0000313|Proteomes:UP000092460};
RN [1] {ECO:0000313|Proteomes:UP000092460}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IAEA {ECO:0000313|Proteomes:UP000092460};
RA Aksoy S., Warren W., Wilson R.K.;
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:GPPI030250-PA}
RP IDENTIFICATION.
RC STRAIN=IAEA {ECO:0000313|EnsemblMetazoa:GPPI030250-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; JXJN01014362; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; JXJN01014363; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A1B0BHH4; -.
DR STRING; 67801.A0A1B0BHH4; -.
DR EnsemblMetazoa; GPPI030250-RA; GPPI030250-PA; GPPI030250.
DR VEuPathDB; VectorBase:GPPI030250; -.
DR Proteomes; UP000092460; Unassembled WGS sequence.
DR GO; GO:0034703; C:cation channel complex; IEA:UniProt.
DR GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR013555; TRP_dom.
DR InterPro; IPR002153; TRPC_channel.
DR NCBIfam; TIGR00870; trp; 1.
DR PANTHER; PTHR10117; TRANSIENT RECEPTOR POTENTIAL CHANNEL; 1.
DR PANTHER; PTHR10117:SF47; TRANSIENT-RECEPTOR-POTENTIAL-LIKE PROTEIN; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF08344; TRP_2; 1.
DR PRINTS; PR01097; TRNSRECEPTRP.
DR SMART; SM00248; ANK; 2.
DR SMART; SM01420; TRP_2; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 335..355
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..388
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 550..573
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 637..659
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 146..178
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 181..243
FT /note="Transient receptor ion channel"
FT /evidence="ECO:0000259|SMART:SM01420"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 953..1018
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1106..1131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 955..974
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 984..1018
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1131 AA; 129595 MW; 8DE87E9E74B6EB5C CRC64;
MGKAENKKHK ASAANHEGND NGSPPIGLPH PLQLEEKKFL LAVERGDIGN VRRILQKSNR
YNHININCMD ALGRRALTLA IDNENLEMVE LLVIMGVDTK DALLHAINAE FVEAVELLLE
HEELIYKEGE LYSWQKVDIN TATFPPDITP LILAAHKNNY EILKILLDRG AAVPVPHDIK
CGCDECVRMS SEDSLRHSLS RVNTYKALSS PSLICLTSND PILTAFELSW ELRNLAFTEQ
ECKSEYMELR RQCQKFAVDL LDQTRTSNEL AVILNYDPEM STYKPGDRMS LRRLTEAINY
KQKKFVAHSN IQQLLAAIWY EGLPGFRRKT LMEKFLCIVE VAVLFPIYCF IYMAAPNCKT
AVLLRKPFMK FLIHASSYLF FLFILILVSQ RADDNVIRIF GTERMKQELS EEQLRQRGRG
PTKLEILVVF YLFGFIWEEV QEIFTVGIHT YLRNMWNFID FLRNSLYVSV ICLRLFAYMQ
QSSEIARDPA MAYVPREKWN DFDPQLIAEG LFAAANVFSA LKLVHLFSIN PHLGPLQISL
GRMVIDIVKF FFIYSLVLFA FACGLNQLLW YFADLEKSKC YVLPDGEADW TGHADSCMKW
RRFGNLFESS QSLFWASFGM VGLDDFELTG IKSYTRFWGL LMFGSYSVIN VIVLLNLLIA
MMSNSYAMID EHSDTEWKFA RTKLWMSYFE DSSTLPPPFN IMPSVKWLIR FFRKSSKEID
RKRSKKRQQN DQENIYENIL RSLVWRYVAA QHRKFEDNPV TEDDINEVKS EISTMRYEML
EIFENSGMDI SSAVKKEKPC RAKRTKVWER RLMKGFQVIP IQSHYEEQSN GNINAIADMQ
EIKIEKAPSR IEKETAKERF RRVAHTVAAQ SATHKWNLVL QGTLKDSQIG RCNKESYKNL
QNLGKAMEEA RKLIQISSHP TSDRESPIPI EFEDEKATTL MELLSKISGD LQDTSIDADN
KRPRVAEFRK KTLAGKKNSQ MTKKRQESAA SENSNSLYGH QTASTPFSKP VSNKTNEEGQ
AELTLTVSGF AGQANKIVGS QQPALKKTAP FPPQQQKQSV HVPFAVELGK AGRRPGFAKP
PPVYQNLPKN FDINVVDLDS QSLSYSMDDL SDASSVGRES PSHRQRDHNQ K
//
