ID A0A1B0BXC6_9MUSC Unreviewed; 739 AA.
AC A0A1B0BXC6;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Cleavage and polyadenylation specificity factor subunit 2 {ECO:0000256|RuleBase:RU365006};
DE AltName: Full=Cleavage and polyadenylation specificity factor 100 kDa subunit {ECO:0000256|RuleBase:RU365006};
OS Glossina palpalis gambiensis.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC Glossinidae; Glossina.
OX NCBI_TaxID=67801 {ECO:0000313|EnsemblMetazoa:GPPI043370-PA, ECO:0000313|Proteomes:UP000092460};
RN [1] {ECO:0000313|Proteomes:UP000092460}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IAEA {ECO:0000313|Proteomes:UP000092460};
RA Aksoy S., Warren W., Wilson R.K.;
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:GPPI043370-PA}
RP IDENTIFICATION.
RC STRAIN=IAEA {ECO:0000313|EnsemblMetazoa:GPPI043370-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU365006}.
CC -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily. RNA-
CC metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
CC {ECO:0000256|RuleBase:RU365006}.
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DR EMBL; JXJN01022185; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A1B0BXC6; -.
DR STRING; 67801.A0A1B0BXC6; -.
DR EnsemblMetazoa; GPPI043370-RA; GPPI043370-PA; GPPI043370.
DR VEuPathDB; VectorBase:GPPI043370; -.
DR Proteomes; UP000092460; Unassembled WGS sequence.
DR GO; GO:0005847; C:mRNA cleavage and polyadenylation specificity factor complex; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006378; P:mRNA polyadenylation; IEA:InterPro.
DR CDD; cd16293; CPSF2-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR022712; Beta_Casp.
DR InterPro; IPR027075; CPSF2.
DR InterPro; IPR025069; Cpsf2_C.
DR InterPro; IPR035639; CPSF2_MBL.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR InterPro; IPR011108; RMMBL.
DR PANTHER; PTHR45922; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2; 1.
DR PANTHER; PTHR45922:SF1; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2; 1.
DR Pfam; PF10996; Beta-Casp; 1.
DR Pfam; PF13299; CPSF100_C; 1.
DR Pfam; PF16661; Lactamase_B_6; 1.
DR Pfam; PF07521; RMMBL; 1.
DR SMART; SM01027; Beta-Casp; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 3: Inferred from homology;
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664,
KW ECO:0000256|RuleBase:RU365006};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU365006};
KW RNA-binding {ECO:0000256|RuleBase:RU365006}.
FT DOMAIN 232..357
FT /note="Beta-Casp"
FT /evidence="ECO:0000259|SMART:SM01027"
SQ SEQUENCE 739 AA; 84714 MW; 54298988760D4E0E CRC64;
MTSIIKLYTI SGAMDESPPC YILQVDEKFD ANFIKDLKRH VHTIDAVLLS HPDVYHLGAL
PYLVGKLGLN CPIYATIPVH KMGQMFMYDL YMSHFNMYDF DLFSLDDVDA AFDKIIQLKY
NQTFSLKGKG YGITITPLPA GHMIGGTIWK ILKVGEEDIV YAMDFNHKKE RHLNGCELER
FQRPSLLITD AFNALYQQAR RRARDEKLMT NILQTVRNNG NVLIAVDTAG RVLELAHMLD
QLWKNRESGL MAYSLALLNN FSYNVVEFAK SQIEWMSDKL MKTFEGARNN PFQFKHMQLC
HNLAELSLLP GPKVVLASTP DLESGFTREL FVQWAGNPIN SVIFTSRTSQ GTLATDLVEN
HISGRKIELD LRRRVELEGA ELEEYLRTQG EKVNRLIVKQ DVEEESSSDS DDDIEMSIIT
GKHDIVIRSE GRQHSGFFKS NKRHNVMFPF QEEKIKCDEY GEVINLDDYR IADMNYEASL
EEHNKENIKK EEMKGEKSKT EDEIQLLEKP TKCFNQRKTI EINCQIQRID FEGRSDGESM
LKILSQLRPR RVIVVHGSED ATQVVAKHCQ QNIGARIFTP HKGEIIDVTT ETHIYQVRLT
EGLVTQLQFQ KSKNAEIAWV DARIGMRKQA IESPNNESNG DNDVTEAAEE DKTFTLESLE
ADEIPVHNAV LINELKLSDF KQVLMRHNIN SEFSGGVLWC CNGTLALRRI DTGKVTMEGC
LSDEYYRIRE LLYEQYACY
//
