ID A0A1B0C5B6_9MUSC Unreviewed; 1901 AA.
AC A0A1B0C5B6;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
OS Glossina palpalis gambiensis.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC Glossinidae; Glossina.
OX NCBI_TaxID=67801 {ECO:0000313|EnsemblMetazoa:GPPI049561-PA, ECO:0000313|Proteomes:UP000092460};
RN [1] {ECO:0000313|Proteomes:UP000092460}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IAEA {ECO:0000313|Proteomes:UP000092460};
RA Aksoy S., Warren W., Wilson R.K.;
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:GPPI049561-PA}
RP IDENTIFICATION.
RC STRAIN=IAEA {ECO:0000313|EnsemblMetazoa:GPPI049561-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR EMBL; JXJN01025926; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 67801.A0A1B0C5B6; -.
DR EnsemblMetazoa; GPPI049561-RA; GPPI049561-PA; GPPI049561.
DR VEuPathDB; VectorBase:GPPI049561; -.
DR Proteomes; UP000092460; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00029; C1; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR000961; AGC-kinase_C.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR22988:SF71; CITRON RHO-INTERACTING KINASE; 1.
DR PANTHER; PTHR22988; MYOTONIC DYSTROPHY S/T KINASE-RELATED; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00036; CNH; 1.
DR SMART; SM00133; S_TK_X; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51285; AGC_KINASE_CTER; 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 124..386
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 387..467
FT /note="AGC-kinase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51285"
FT DOMAIN 1412..1464
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 1542..1832
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 1365..1396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 475..540
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 577..679
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 719..1018
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1061..1228
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1309..1336
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1365..1381
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 153
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1901 AA; 219202 MW; 0B2411DC7D83C30C CRC64;
MEKIVNVSII KNTISKMAQP IDAITVRATR LNNVLLGSGR SYGISTAFSD SMTRESLLDA
FCVLYNECDK EALRNRDKNI SEFVNKCKFL LYIDSWIWIF KSQSFPDRNV IEEARRLRVN
VTDFNVRNLI GEGSFGNVHL VVEHQTGDVY AMKKIKKTIV TAVQVKEERD IMSRRCSEWI
TNLQYAFQDK DYLYLVMEYL PGGDLFSLMS RHGSFDEDLT RFYLAEMTVA IHALHEMGYV
HRDIKPENIL IDRLGHIKLA DFGNAATLNR DGHVFSLSPV GTPDYIAPEL LQSSRYKNMH
DVSCDYWSMG IIGYELICEI TPFHDDDIHQ TYSKILSYCE ESQLKKLVAF PSELKLTEHF
KNLIESLVTS PSNRLGYENL RKHAFFNNIE WNNLRSMVPP IIPSLKSRDD ISNFEDNARK
KTRACAVISK NSKKSLTTAM MSNDFCGKDL PFVGYSFVHM EWQKIEQGAI DDARYIKLDN
KLKDLQQKYK ERIDDISKLK QELLRAELTI KQSGTQSRIL QDAKDEMNNM KDIIKKKNAE
LANCHTEIKT LRSSLRVEKE VGEKKDASVT EILRSARQKY EDALNKSDRR YERKIAEKKA
EISAILSKLN ERDAELSAKA EEYLHLQEKM DNYKELLSQQ KQQAQKDREE FEEHKTHLIE
TYEQKLLQMR EKIRFVRNSK SRLSMELRDV RTELNDNLNI RRSSEEAKLM TEKSNEDILQ
RLNREIEANN ELHKTVENLE QEMQRLQRDL QVAECSKNLT ESALATPFET APGSLTDISK
IEDQLKADLE TAKENENVQR MRADKLQETV EKLQEMLEGC NEQCTSPVKP LAAPRQKKST
TNAGDLLEKK NEKLEDQLAT LREEMIVERR AARSANLSLW RMEKLVEKLT DEKNTLERRM
QLTEGRIKKA QHDREDALRL CKANEEAKVE REQRIEELKQ EISALKADIK RGNAMREKCE
QERMKCKMEV IEHIANLKKL EENLAEHRYR TQPLSDKCKE LEFENKRLIG QINDEKDRLL
VIENQNSSLQ IKLQNQIKNY GRLKYACMIT DKQLTEIEAM LEKEQASNKA NQQKLKQLLS
EKDQRLEIEA QLKKQLFDEK EQRQAAELNG ENLNTKLEEQ HQNIEHLQKE LEATNQRLML
KTAELFHTQE RVEILQSEKQ NVLTRIENHA REIEIYTHEI EHLKEEKTGV ITELFHAKEA
ANRLNMDLKD ATTQILDLQN ELKDVRGILE EKENFYLQRE IKCETTLVQH KKLIDYLQLK
VEDLSQRKKK TFADKLFGSN TNANRSCPCS ASSRKENLCP NVIENSIVYR TLHEELRREK
LLNKTLKEQL DRSKLNKNWL RSPLKKVEKD EQSIDDAQGL EINKTIKENA TKSPVKKGKV
QQEQSDNQDL KKSMEKLQQI SGNSSAKYLQ LHHRFEQTRQ ESNIDASQCA VCHKALLVTS
PYLECKVCKR VVHRKCRDDV NVPCDSIENI LNDNAIKSDC IETMALEPSA PTRTDLDTDS
LGKYSYEAKL DNLDEANAAA LQNSYNGSLI FTIPIKNEQG TSLEVACAYE MEENRILLLG
CNTGLYAYHV KQQHLVHIAG IDAVSCIAIS APLAKAILVS SHGESLYQCD LRHLQSRSQA
NACLKPALEA SILDLSFDNR GTAEKWQLIQ VSEETEQPLD TVAIAATSSR IVILKYDVKQ
QKFKPVQALD TATSVSSILF TRHTAIVSSD KFFEIDLSTY GAEEFVDIAD QSLSHSSTCQ
PVVALRISKQ EFLLCFMECG VFVDEYGCRS RPYDINWGYT PTGFLYRAPF LYVAHFQSVQ
IMRVHRSYSK EMSDKYIDAD TNDAVHELKK IHLSFYMPTL LCNSGKHNIY MLAKQKEIGA
QEIYHLDALQ AFKLQYNGSQ DTVSSITTSI TAESLTTIST D
//
