ID A0A1B0CBH9_LUTLO Unreviewed; 2438 AA.
AC A0A1B0CBH9;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=ribonuclease III {ECO:0000256|ARBA:ARBA00012177};
DE EC=3.1.26.3 {ECO:0000256|ARBA:ARBA00012177};
OS Lutzomyia longipalpis (Sand fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Psychodoidea; Psychodidae;
OC Lutzomyia; Lutzomyia.
OX NCBI_TaxID=7200 {ECO:0000313|EnsemblMetazoa:LLOJ001478-PA, ECO:0000313|Proteomes:UP000092461};
RN [1] {ECO:0000313|Proteomes:UP000092461}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Jacobina {ECO:0000313|Proteomes:UP000092461};
RA Richards S., Qu C., Dillon R., Worley K., Scherer S., Batterton M.,
RA Taylor A., Hawes A., Hernandez B., Kovar C., Mandapat C., Pham C., Qu C.,
RA Jing C., Bess C., Bandaranaike D., Ngo D., Ongeri F., Arias F., Lara F.,
RA Weissenberger G., Kamau G., Han H., Shen H., Dinh H., Khalil I., Jones J.,
RA Shafer J., Jayaseelan J., Quiroz J., Blankenburg K., Nguyen L., Jackson L.,
RA Francisco L., Tang L.-Y., Pu L.-L., Perales L., Lorensuhewa L.,
RA Munidasa M., Coyle M., Taylor M., Puazo M., Firestine M., Scheel M.,
RA Javaid M., Wang M., Li M., Tabassum N., Saada N., Osuji N., Aqrawi P.,
RA Fu Q., Thornton R., Raj R., Goodspeed R., Mata R., Najjar R., Gubbala S.,
RA Lee S., Denson S., Patil S., Macmil S., Qi S., Matskevitch T.,
RA Palculict T., Mathew T., Vee V., Velamala V., Korchina V., Cai W., Liu W.,
RA Dai W., Zou X., Zhu Y., Zhang Y., Wu Y.-Q., Xin Y., Nazarath L., Kovar C.,
RA Han Y., Muzny D., Gibbs R.;
RT "Whole Genome Assembly of Lutzomyia longipalpis.";
RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:LLOJ001478-PA}
RP IDENTIFICATION.
RC STRAIN=Jacobina {ECO:0000313|EnsemblMetazoa:LLOJ001478-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.3;
CC Evidence={ECO:0000256|ARBA:ARBA00000109};
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DR EMBL; AJWK01005166; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJWK01005167; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJWK01005168; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJWK01005169; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJWK01005170; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EnsemblMetazoa; LLOJ001478-RA; LLOJ001478-PA; LLOJ001478.
DR VEuPathDB; VectorBase:LLOJ001478; -.
DR OrthoDB; 5486676at2759; -.
DR Proteomes; UP000092461; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0004525; F:ribonuclease III activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0031054; P:pre-miRNA processing; IEA:InterPro.
DR GO; GO:0006364; P:rRNA processing; IEA:InterPro.
DR CDD; cd19877; DSRM_RNAse_III_meta_like; 2.
DR CDD; cd00593; RIBOc; 4.
DR Gene3D; 1.10.1530.10; -; 2.
DR Gene3D; 3.30.160.20; -; 2.
DR Gene3D; 1.10.1520.10; Ribonuclease III domain; 6.
DR HAMAP; MF_00104; RNase_III; 2.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR043144; Mal/L-sulf/L-lact_DH-like_ah.
DR InterPro; IPR043143; Mal/L-sulf/L-lact_DH-like_NADP.
DR InterPro; IPR036111; Mal/L-sulfo/L-lacto_DH-like_sf.
DR InterPro; IPR003767; Malate/L-lactate_DH-like.
DR InterPro; IPR011907; RNase_III.
DR InterPro; IPR000999; RNase_III_dom.
DR InterPro; IPR044442; RNAse_III_DSRM__animal.
DR InterPro; IPR036389; RNase_III_sf.
DR PANTHER; PTHR11207:SF0; RIBONUCLEASE 3; 1.
DR PANTHER; PTHR11207; RIBONUCLEASE III; 1.
DR Pfam; PF00035; dsrm; 2.
DR Pfam; PF02615; Ldh_2; 2.
DR Pfam; PF00636; Ribonuclease_3; 2.
DR SMART; SM00358; DSRM; 2.
DR SMART; SM00535; RIBOc; 4.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 2.
DR SUPFAM; SSF89733; L-sulfolactate dehydrogenase-like; 2.
DR SUPFAM; SSF69065; RNase III domain-like; 4.
DR PROSITE; PS50137; DS_RBD; 2.
DR PROSITE; PS00517; RNASE_3_1; 2.
DR PROSITE; PS50142; RNASE_3_2; 4.
PE 3: Inferred from homology;
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00266}.
FT DOMAIN 596..736
FT /note="RNase III"
FT /evidence="ECO:0000259|PROSITE:PS50142"
FT DOMAIN 788..911
FT /note="RNase III"
FT /evidence="ECO:0000259|PROSITE:PS50142"
FT DOMAIN 938..1013
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 1481..1621
FT /note="RNase III"
FT /evidence="ECO:0000259|PROSITE:PS50142"
FT DOMAIN 1673..1796
FT /note="RNase III"
FT /evidence="ECO:0000259|PROSITE:PS50142"
FT DOMAIN 1823..1898
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT REGION 1..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1027..1123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1912..2008
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..32
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..98
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1033..1057
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1079..1096
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1918..1942
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2438 AA; 277313 MW; 2174058FDC183D50 CRC64;
MYLILTSRSS SRSSPPSSRR RDSERRKYSE RSTRSSSYSS SRRSASRSRD YDRRSRNRSR
ESRDDRGRKQ QHEEKRRESR ERRSHSHGGR AVEPKKKETE REILLAKWRK NYCETSEDIA
RKLAELADDK EKEHWIRSSP ADIYYKRISD TVVEATPRLD ALCSLFEVEL VQRAAKVKET
QTPYNPPPRK RKTHFCRHKS EKCSSSDSSD EDLELQEDCT MEELSRKINH PYRLHTDLWY
NDPGEMNDGP LCRCSAKSRR IGIRHGIYPG ENGFPKCLPN SNNADKLYHY RITISPPTNF
LTKTPTIIKY DQHEFLFEGF SLLSHVPIGE LPTCKVIRFN IEYTVLYIEE KIPENFTIKE
LDLFYTYLFT ELLELVDFNL LPNTTATDVC PFFHFLPRFV RDLSDNGKEV LAMSEVLRYL
LDNSGPLVDR RTLADMMHIN QNIWQDYVDD IKGMIVVNPG MKPCSVRVDQ LDRNVSDLPE
CKDADGTVHP VIVHFGIRPP QLSYAGNPEY QKAWREYVKY RHLIANMSKP TYDDKRRLEA
KEAKLQEMRM LGRMKRNITI AVSSKNFRRT GIMCDIVQHA MLIPVLTCHL RFHRALDVLE
ENIEYKFTNR YLLQLALTHP SYKENFGTNP DHARNSLTNC GIRQPEYGDR KIHYMNTRKR
GINTLINIMS RFGKEYETAS NITHNERLEF LGDAKLHLEE FMLYAHGSDL CHELELRHAM
ANCFEALMGA LLLDGGIEVA DKVFASALFL ESDDLKKVWE KNPPHPLQEQ EPLGDRQWIE
SYQMLQNLTK FEDSIGVKFQ HIRLLARAFT DRSIGFTHLT LGSNQRLEFL GDTVLQLICS
EYLYRYFPEH HEGHLSLLRS SLVNNRTQAV VCDDLGMTQY AVYSNPKAEL KTKDRADLLE
SFLGALYVDR GLEYCQTFCQ VCLFPRLNVF IMNQDWNDPK SKLQQCCLTL RSMDGGEPDI
PVYKVIESIG PTNTRVYTVA VYFREKRLAC ATGHSIQQAE MNAAKKALEN SHDLFPQLDH
QKRVIARSVK RQKGSSVDVK RKDGHSDRAR SSKDNLFDDS NLPKQYRARE DISSEEDFSE
SDSSSSGATS SGGSEKSGKR IRPKKRKRSP AGNEANKGNS EENLQDILSS VSDEEIPDEK
TTYEEGAEIY KNFNHNLLSK MPLQLLIRKA NNILVTATRQ NTSLIIHRTL SQGKMSANRV
KVAEAKRFVR DCFLAAQVRA ENAQAMADLL IEADYRGHFS HGMNRLEMYI NDLDKKTTDG
NVEPVVLKET PATAWIDGRH GLGVVVGNFS MDLAIKKAKE VGVGWTCAKG PLVDRRTLAD
MMHINQNIWQ DYVDDIKGMI VVNPGMKPCS VRVDQLDRNV SDLPECKDAD GTVHPVIVHF
GIRPPQLSYA GNPEYQKAWR EYVKYRHLIA NMSKPTYDDK RRLEAKEAKL QEMRMLGRMK
RNITIAVSSK NFRRTGIMCD IVQHAMLIPV LTCHLRFHRA LDVLEENIEY KFTNRYLLQL
ALTHPSYKEN FGTNPDHARN SLTNCGIRQP EYGDRKIHYM NTRKRGINTL INIMSRFGKE
YETASNITHN ERLEFLGDAK LHLEEFMLYA HGSDLCHELE LRHAMANCFE ALMGALLLDG
GIEVADKVFA SALFLESDDL KKVWEKNPPH PLQEQEPLGD RQWIESYQML QNLTKFEDSI
GVKFQHIRLL ARAFTDRSIG FTHLTLGSNQ RLEFLGDTVL QLICSEYLYR YFPEHHEGHL
SLLRSSLVNN RTQAVVCDDL GMTQYAVYSN PKAELKTKDR ADLLESFLGA LYVDRGLEYC
QTFCQVCLFP RLNVFIMNQD WNDPKSKLQQ CCLTLRSMDG GEPDIPVYKV IESIGPTNTR
VYTVAVYFRE KRLACATGHS IQQAEMNAAK KALENSHDLF PQLDHQKRVI ARSVKRQKGS
SVDVKRKDGH SDRARSSKDN LFDDSNLPKQ YRAREDISSE EDFSESDSSS SGDTSSGGSE
KSGKRIRPKK RKRSPAGNEA NKGNSEENLQ DILSSVSDEE IPDEKTTYEE GAEIYKNFNH
NLPKMPLQLL IRKANNILVT ATRQNTSLII HRTLSQGKMS GNRVKVAEAK RFVRDCFLAA
QVRAENAQAM ADLLIEADYR GHFSHGMNRL EMYINDLDKK TTDGNVEPVV LKETPATAWI
DGRHGLGVVV GNFSMDLAIK KAKEVGVGWT CAKGSNHYGI AGWYTLRAMK EGLIGLSMTN
TSPFMSPTRS KEAALGTNPL SFGAPASNGD SFLLDMATTA VAVGKIEMQI RKDEPIPRGW
AQDPSGQTTT DANLAFNSGC LMPLGGEELT SGYKGYGLGA MVEIMCGIMS GANYASNIRK
WSHAGSEELA NLGQCFIAVD PNCFAPGFAD RLGDLNNLLR AVPPADPNKP VLVAGDPEAA
HMAKVDKDGG INYHENQLKS CQNLAKRLNV APLELALK
//
