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Database: UniProt
Entry: A0A1B0CJF6_LUTLO
LinkDB: A0A1B0CJF6_LUTLO
Original site: A0A1B0CJF6_LUTLO 
ID   A0A1B0CJF6_LUTLO        Unreviewed;       140 AA.
AC   A0A1B0CJF6;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=Adenosine kinase {ECO:0000256|ARBA:ARBA00012119, ECO:0000256|RuleBase:RU368116};
DE            Short=AK {ECO:0000256|RuleBase:RU368116};
DE            EC=2.7.1.20 {ECO:0000256|ARBA:ARBA00012119, ECO:0000256|RuleBase:RU368116};
DE   AltName: Full=Adenosine 5'-phosphotransferase {ECO:0000256|RuleBase:RU368116};
OS   Lutzomyia longipalpis (Sand fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Psychodoidea; Psychodidae;
OC   Lutzomyia; Lutzomyia.
OX   NCBI_TaxID=7200 {ECO:0000313|EnsemblMetazoa:LLOJ004658-PA, ECO:0000313|Proteomes:UP000092461};
RN   [1] {ECO:0000313|Proteomes:UP000092461}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Jacobina {ECO:0000313|Proteomes:UP000092461};
RA   Richards S., Qu C., Dillon R., Worley K., Scherer S., Batterton M.,
RA   Taylor A., Hawes A., Hernandez B., Kovar C., Mandapat C., Pham C., Qu C.,
RA   Jing C., Bess C., Bandaranaike D., Ngo D., Ongeri F., Arias F., Lara F.,
RA   Weissenberger G., Kamau G., Han H., Shen H., Dinh H., Khalil I., Jones J.,
RA   Shafer J., Jayaseelan J., Quiroz J., Blankenburg K., Nguyen L., Jackson L.,
RA   Francisco L., Tang L.-Y., Pu L.-L., Perales L., Lorensuhewa L.,
RA   Munidasa M., Coyle M., Taylor M., Puazo M., Firestine M., Scheel M.,
RA   Javaid M., Wang M., Li M., Tabassum N., Saada N., Osuji N., Aqrawi P.,
RA   Fu Q., Thornton R., Raj R., Goodspeed R., Mata R., Najjar R., Gubbala S.,
RA   Lee S., Denson S., Patil S., Macmil S., Qi S., Matskevitch T.,
RA   Palculict T., Mathew T., Vee V., Velamala V., Korchina V., Cai W., Liu W.,
RA   Dai W., Zou X., Zhu Y., Zhang Y., Wu Y.-Q., Xin Y., Nazarath L., Kovar C.,
RA   Han Y., Muzny D., Gibbs R.;
RT   "Whole Genome Assembly of Lutzomyia longipalpis.";
RL   Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:LLOJ004658-PA}
RP   IDENTIFICATION.
RC   STRAIN=Jacobina {ECO:0000313|EnsemblMetazoa:LLOJ004658-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- FUNCTION: ATP dependent phosphorylation of adenosine and other related
CC       nucleoside analogs to monophosphate derivatives.
CC       {ECO:0000256|RuleBase:RU368116}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenosine + ATP = ADP + AMP + H(+); Xref=Rhea:RHEA:20824,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16335, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; EC=2.7.1.20;
CC         Evidence={ECO:0000256|RuleBase:RU368116};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|RuleBase:RU368116};
CC       Note=Binds 3 Mg(2+) ions per subunit. {ECO:0000256|RuleBase:RU368116};
CC   -!- PATHWAY: Purine metabolism; AMP biosynthesis via salvage pathway; AMP
CC       from adenosine: step 1/1. {ECO:0000256|ARBA:ARBA00004801,
CC       ECO:0000256|RuleBase:RU368116}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|RuleBase:RU368116}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU368116}.
CC   -!- SIMILARITY: Belongs to the carbohydrate kinase PfkB family.
CC       {ECO:0000256|ARBA:ARBA00010688, ECO:0000256|RuleBase:RU368116}.
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DR   EMBL; AJWK01014546; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A1B0CJF6; -.
DR   EnsemblMetazoa; LLOJ004658-RA; LLOJ004658-PA; LLOJ004658.
DR   VEuPathDB; VectorBase:LLOJ004658; -.
DR   OrthoDB; 22683at2759; -.
DR   UniPathway; UPA00588; UER00659.
DR   Proteomes; UP000092461; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004001; F:adenosine kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0044209; P:AMP salvage; IEA:UniProtKB-UniRule.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0006166; P:purine ribonucleoside salvage; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.1190.20; -; 1.
DR   InterPro; IPR001805; Adenokinase.
DR   InterPro; IPR011611; PfkB_dom.
DR   InterPro; IPR029056; Ribokinase-like.
DR   PANTHER; PTHR45769; ADENOSINE KINASE; 1.
DR   PANTHER; PTHR45769:SF5; ADY43A; 1.
DR   Pfam; PF00294; PfkB; 1.
DR   SUPFAM; SSF53613; Ribokinase-like; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU368116};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU368116};
KW   Magnesium {ECO:0000256|RuleBase:RU368116};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU368116}; Nucleus {ECO:0000256|RuleBase:RU368116};
KW   Purine salvage {ECO:0000256|ARBA:ARBA00022726,
KW   ECO:0000256|RuleBase:RU368116};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU368116}.
FT   DOMAIN          10..138
FT                   /note="Carbohydrate kinase PfkB"
FT                   /evidence="ECO:0000259|Pfam:PF00294"
SQ   SEQUENCE   140 AA;  15385 MW;  29AD8757AF561D37 CRC64;
     MTKYIVENLR EEFKFLVQAC DLIFGNVSEF STLARTSGCE NLTSWVDTIA RDAAKDKIFV
     ITDGEAPVRL IEIINGVVES QEIPVEKVEN IKDTTGAGDA FVAGFFSAYI RGKTAKECVQ
     EGIHVAGRTL TQIGCHLPEE
//
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