ID   A0A1B0CKT2_LUTLO        Unreviewed;       978 AA.
AC   A0A1B0CKT2;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=Acyl-coenzyme A oxidase {ECO:0008006|Google:ProtNLM};
OS   Lutzomyia longipalpis (Sand fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Psychodoidea; Psychodidae;
OC   Lutzomyia; Lutzomyia.
OX   NCBI_TaxID=7200 {ECO:0000313|EnsemblMetazoa:LLOJ005219-PA, ECO:0000313|Proteomes:UP000092461};
RN   [1] {ECO:0000313|Proteomes:UP000092461}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Jacobina {ECO:0000313|Proteomes:UP000092461};
RA   Richards S., Qu C., Dillon R., Worley K., Scherer S., Batterton M.,
RA   Taylor A., Hawes A., Hernandez B., Kovar C., Mandapat C., Pham C., Qu C.,
RA   Jing C., Bess C., Bandaranaike D., Ngo D., Ongeri F., Arias F., Lara F.,
RA   Weissenberger G., Kamau G., Han H., Shen H., Dinh H., Khalil I., Jones J.,
RA   Shafer J., Jayaseelan J., Quiroz J., Blankenburg K., Nguyen L., Jackson L.,
RA   Francisco L., Tang L.-Y., Pu L.-L., Perales L., Lorensuhewa L.,
RA   Munidasa M., Coyle M., Taylor M., Puazo M., Firestine M., Scheel M.,
RA   Javaid M., Wang M., Li M., Tabassum N., Saada N., Osuji N., Aqrawi P.,
RA   Fu Q., Thornton R., Raj R., Goodspeed R., Mata R., Najjar R., Gubbala S.,
RA   Lee S., Denson S., Patil S., Macmil S., Qi S., Matskevitch T.,
RA   Palculict T., Mathew T., Vee V., Velamala V., Korchina V., Cai W., Liu W.,
RA   Dai W., Zou X., Zhu Y., Zhang Y., Wu Y.-Q., Xin Y., Nazarath L., Kovar C.,
RA   Han Y., Muzny D., Gibbs R.;
RT   "Whole Genome Assembly of Lutzomyia longipalpis.";
RL   Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:LLOJ005219-PA}
RP   IDENTIFICATION.
RC   STRAIN=Jacobina {ECO:0000313|EnsemblMetazoa:LLOJ005219-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
CC   -!- PATHWAY: Lipid metabolism; peroxisomal fatty acid beta-oxidation.
CC       {ECO:0000256|ARBA:ARBA00004846}.
CC   -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
CC   -!- SIMILARITY: Belongs to the acyl-CoA oxidase family.
CC       {ECO:0000256|ARBA:ARBA00006288}.
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DR   EMBL; AJWK01016606; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AJWK01016607; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AJWK01016608; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A1B0CKT2; -.
DR   EnsemblMetazoa; LLOJ005219-RA; LLOJ005219-PA; LLOJ005219.
DR   VEuPathDB; VectorBase:LLOJ005219; -.
DR   OrthoDB; 5777at2759; -.
DR   Proteomes; UP000092461; Unassembled WGS sequence.
DR   GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR   GO; GO:0003997; F:acyl-CoA oxidase activity; IEA:InterPro.
DR   GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR   GO; GO:0009058; P:biosynthetic process; IEA:UniProt.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:InterPro.
DR   Gene3D; 1.10.540.10; Acyl-CoA dehydrogenase/oxidase, N-terminal domain; 1.
DR   Gene3D; 2.40.110.10; Butyryl-CoA Dehydrogenase, subunit A, domain 2; 2.
DR   Gene3D; 1.20.140.10; Butyryl-CoA Dehydrogenase, subunit A, domain 3; 3.
DR   InterPro; IPR029320; Acyl-CoA_ox_N.
DR   InterPro; IPR046373; Acyl-CoA_Oxase/DH_mid-dom_sf.
DR   InterPro; IPR012258; Acyl-CoA_oxidase.
DR   InterPro; IPR002655; Acyl-CoA_oxidase_C.
DR   InterPro; IPR036250; AcylCo_DH-like_C.
DR   InterPro; IPR037069; AcylCoA_DH/ox_N_sf.
DR   InterPro; IPR009100; AcylCoA_DH/oxidase_NM_dom_sf.
DR   PANTHER; PTHR10909; ELECTRON TRANSPORT OXIDOREDUCTASE; 1.
DR   PANTHER; PTHR10909:SF250; PEROXISOMAL ACYL-COENZYME A OXIDASE 1; 1.
DR   Pfam; PF01756; ACOX; 1.
DR   Pfam; PF14749; Acyl-CoA_ox_N; 1.
DR   SUPFAM; SSF47203; Acyl-CoA dehydrogenase C-terminal domain-like; 3.
DR   SUPFAM; SSF56645; Acyl-CoA dehydrogenase NM domain-like; 2.
PE   3: Inferred from homology;
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Peroxisome {ECO:0000256|ARBA:ARBA00023140}.
FT   DOMAIN          20..143
FT                   /note="Acyl-coenzyme A oxidase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14749"
FT   DOMAIN          794..972
FT                   /note="Acyl-CoA oxidase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01756"
SQ   SEQUENCE   978 AA;  108692 MW;  9083283C61FD7D3D CRC64;
     MGRKVNEDLA KERWSCGIKS DEFTAWWYGG WDKVAEKRKY ESILKHPEVQ HEIPLHYLSH
     EEMYEEKVRQ STEVLKKVKE LREADMNPDE YNDFLGKMEI LGMLGTSSPI EVHFSMFIPT
     IMSQATEEQQ KKWLKRARRG EIIGTYAQTE MGHGTFIRGL QTTATYDEKT QEFVLNSPQI
     SAFKFWPGGL GHTANCAIVM AQLIIRGERQ GIFPFFVQIR DENTHMPLRG VKVGDIGAKM
     GLKSTNNGFL GFTNHRIPRE NMLMKNAQVL EDGTFVKAPM SVLTYGTMVF VRVMIVRDMS
     NRLAQAATIA TRYSAVRKQS PINPDEPEPQ ILDHVTQQNK IFPQLAKSVI FKLAADLIID
     IYNSVNSDLA RGKHDRLPEL HALSCALKAI SSTDAVAGVE ICRLSCGGHG YLECSGFPTL
     LGFVAAAYTY EGENTVLLLQ TARYLMKAAK DPDLSPTVAF LKRYPDYKMK KRWDGSIGGM
     IEAFEAVAAA KIRIAAESVE QRILGHTANC AIVMAQLIIR GERQGIFPFF VQIRDENTHM
     PLRGVKVGDI GAKMGLKSTN NGFLGFTNHR IPRENTLMKN AQVLEDGTFV KAPMSVLTYG
     TMVFVRVMIV RDMSNRLAQA ATIATRYSAV RKQSPINPDE PEPQILDHVT QQNKIFPQLA
     KSVIFKLAAD LIIDIYNSVN SDLARGKHDR LPELHALSCA LKAISSTDAV AGVEICRLSC
     GGHGYLECSG FPTLLGFVAA AYTYEGENTV LLLQTARYLM KAAKDPDLSP TVAFLKRYPD
     YKMKKRWDGS IGGMIEAFEA VAAAKIRIAA ESVEQRIREG KKPGTAANLS SIELVAAADA
     HCRAFILRAG AESMEKVSKS VSPALAGVLK DLLELYAVDA AKKALGDLQR FTTISDGDVR
     QLQRRLEGVL ARLRPNAVAI VDGFDFPDEV LKSALGAYDG NVYERIYEDA MKSPLNYEPV
     NASFHKYLKP FTKGNSKL
//