ID A0A1B0CL59_LUTLO Unreviewed; 1756 AA.
AC A0A1B0CL59;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 22-FEB-2023, entry version 25.
DE SubName: Full=Putative peripheral benzodiazepine receptor prax-1 {ECO:0000313|EMBL:MBC1175211.1};
OS Lutzomyia longipalpis (Sand fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Psychodoidea; Psychodidae;
OC Lutzomyia; Lutzomyia.
OX NCBI_TaxID=7200 {ECO:0000313|EnsemblMetazoa:LLOJ005346-PA, ECO:0000313|Proteomes:UP000092461};
RN [1] {ECO:0000313|Proteomes:UP000092461}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Jacobina {ECO:0000313|Proteomes:UP000092461};
RA Richards S., Qu C., Dillon R., Worley K., Scherer S., Batterton M.,
RA Taylor A., Hawes A., Hernandez B., Kovar C., Mandapat C., Pham C., Qu C.,
RA Jing C., Bess C., Bandaranaike D., Ngo D., Ongeri F., Arias F., Lara F.,
RA Weissenberger G., Kamau G., Han H., Shen H., Dinh H., Khalil I., Jones J.,
RA Shafer J., Jayaseelan J., Quiroz J., Blankenburg K., Nguyen L., Jackson L.,
RA Francisco L., Tang L.-Y., Pu L.-L., Perales L., Lorensuhewa L.,
RA Munidasa M., Coyle M., Taylor M., Puazo M., Firestine M., Scheel M.,
RA Javaid M., Wang M., Li M., Tabassum N., Saada N., Osuji N., Aqrawi P.,
RA Fu Q., Thornton R., Raj R., Goodspeed R., Mata R., Najjar R., Gubbala S.,
RA Lee S., Denson S., Patil S., Macmil S., Qi S., Matskevitch T.,
RA Palculict T., Mathew T., Vee V., Velamala V., Korchina V., Cai W., Liu W.,
RA Dai W., Zou X., Zhu Y., Zhang Y., Wu Y.-Q., Xin Y., Nazarath L., Kovar C.,
RA Han Y., Muzny D., Gibbs R.;
RT "Whole Genome Assembly of Lutzomyia longipalpis.";
RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:MBC1175211.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Jacobina {ECO:0000313|EMBL:MBC1175211.1};
RC TISSUE=Midgut {ECO:0000313|EMBL:MBC1175211.1};
RA Coutinho-Abreu I.V., Serafim T.D., Meneses C., Kamhawi S., Oliveira F.,
RA Valenzuela J.G.;
RT "Leishmania infection induces a limited differential gene expression in the
RT sand fly midgut.";
RL BMC 21:608-608(2020).
RN [3] {ECO:0000313|EnsemblMetazoa:LLOJ005346-PA}
RP IDENTIFICATION.
RC STRAIN=Jacobina {ECO:0000313|EnsemblMetazoa:LLOJ005346-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RIMBP family.
CC {ECO:0000256|ARBA:ARBA00010749}.
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DR EMBL; AJWK01016940; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJWK01016941; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJWK01016942; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJWK01016943; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GITU01006508; MBC1175211.1; -; Transcribed_RNA.
DR EnsemblMetazoa; LLOJ005346-RA; LLOJ005346-PA; LLOJ005346.
DR VEuPathDB; VectorBase:LLOJ005346; -.
DR OrthoDB; 5403222at2759; -.
DR Proteomes; UP000092461; Unassembled WGS sequence.
DR CDD; cd00063; FN3; 2.
DR CDD; cd12012; SH3_RIM-BP_2; 1.
DR CDD; cd12013; SH3_RIM-BP_3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 2.30.30.40; SH3 Domains; 4.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR035753; RIM-BP_SH3_2.
DR InterPro; IPR035755; RIM-BP_SH3_3.
DR InterPro; IPR040325; RIMBP1/2/3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR14234; RIM BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR14234:SF19; RIM-BINDING PROTEIN, ISOFORM F; 1.
DR Pfam; PF07653; SH3_2; 3.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00326; SH3; 4.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF50044; SH3-domain; 4.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50002; SH3; 4.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Receptor {ECO:0000313|EMBL:MBC1175211.1};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 472..536
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 651..741
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 745..830
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 844..940
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1194..1262
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1296..1363
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1379..1455
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 554..574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 587..614
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 812..847
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 940..996
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1012..1190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1378..1405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1468..1543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1560..1595
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1620..1640
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1705..1731
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 46..115
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 955..996
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1065..1085
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1093..1190
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1513..1535
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1710..1731
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1756 AA; 186310 MW; B9312A55E0C1F56C CRC64;
MVYLREVDSY ICIGCRAFKK AVLSSGAFIR ELTMSYDTLG VSDAMLDSLS LQLREAEARR
AEAERAHQEA LAQLRGMTSG LSRTVEPLDA LQSKARELEK KAALETVRCE ELQLELSAAI
KSKSGRPQVT VPPATVTWAP TSGSEIDRIM AKIEQARLSI ANDNRILAEL EHPRTTGPGV
STIGAPPTSL GAGISSSLCP TSISSLTGGA GASSYAAVIT SSTSSHALTT TDGILSSAAA
AGSAAAAAAG VGGPSATSFP GANVSPLPVR AHPISTMPPL CQSTTMPVLS LHNSYSLPSG
SASYTLGLSG APGASSYTYG TTVGSAGVGS VLGAAGLTGA ASTSLIGTSG LAGLGGTSLS
SGLGGYNTSS YSTYTNPLLT SGAMKLKSLD EIDLGLGRYG NRAGTPCSPI PPPSWGIDTY
SGLDGVNPTF MHTQRPLSRL GGLDMDSRQH GFLALNGTGE PQVDMLDIPG KGRCCVFIAR
FPYDPPDDSE GELTLCAGDY LLVWGSGEPQ SGYYDAELLD GRRGLVSASF VQRLIGDDLL
EFHQAVVTTL RDADDAPVPL DPAPLPPNNP LMTHTSEDMA RLSETHGDLG TDQMEDEADT
DPAPLPPNNP LMTHTSEDVA RLSETHGDLG TDQMEDEADT ADLMFSVLVP APRHLTLERQ
LNKSVLIGWS MPEPAGYNQI ESYHVYVDGV LKVTVKANER TRALVEGVDS TRPHRISVRS
VTQNRRTSRD AACTMIIGRD TSHLGPSAVR ASNITCSSAV ISWLPANSNH QHVVCVNNVE
VRTVKPGVYR HTITGLAPST QYRVTVRAKH LRAPGQNPPP APPPEEAPGA YTDFRTLAKG
LPDPPQEIQV EAGPQDGTLL VTWQPVSRPP SSGPVTGYAV YADGKKVTDV DSPTGDHALI
DIGKLVGLNP KAVTVRTKSR DSQSSDSQPT AIPIRNAARN RAQHAPHTGI PPHMRSQRPG
QQQQQPQQPG MMQQQNPGQM QMNQQMPMTQ QQQQVIEHDE NLSDKEVFPG SMHQQHGLMQ
GSQQVRGGSG GGIPAIEITK DGPGDTTYVS DDSEYQETGR RRSAPAAHQP QQQGYQTNPL
SRNPADRVRP QNPGMGPNQQ SHQQMGQRPQ HPQQQQQPFY GGPSTGSAQQ RGQMGQIGQM
GQMGQMGQMG QMGQMGQMGQ MGQMGQMSQQ PQQQQRVGMA QGRGQMSQQQ QQMKKARFFM
AMFDYDPSTM SPNPDSCEEE LPFQEGDTIK VYGDKDPDGF YWGELRGRRG YVPHNMVTEI
EEGQVGAQGG APLTTGTTQS VRGVSRDRWG DIYATSSVKR MIALYDYDPQ ELSPNVDAEV
ELSFKTGDVV LVYGEMDEDG FYMGELDGVR GLVPSNFLAE APEQYNNQMA SGGMGRGGMN
NRGGRAAVPG GSGPGARGPP PPPRDNMNMG PVELSFKTGD VVLVYGEMDE DGFYMGELDG
VRGLVPSNFL AEAPEQYNNQ MASGGMGRGG MNNRGGRAAV PGGSGPGARG PPPPPRDNMN
MGPVGVNQRG QQMRKDARPT SPTLLDTTGH PAPDHQTQGM QGKGGMIGRA IGINMQQQPG
QQKMQQPGQQ QMGQQQMGQQ PMGQQQMGQQ QMGQQQMGQQ QMGQQQMGMG MGGMQQQPMM
MQQQQQQQQQ QYPATTTSAP QTGGMFSTAS SLFSGATNAA TGGLFNKQPP KGPQVVPQPG
MTQQPFGGQP AGQMGGAMGG GMGAFGGGLQ GAQQPQQGAM PGQAMPGQQG PNLMQKLNEI
TAPGGDILSK GKELIS
//
