ID A0A1B0CLF6_LUTLO Unreviewed; 832 AA.
AC A0A1B0CLF6;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Ionotropic receptor {ECO:0000313|EnsemblMetazoa:LLOJ005443-PA};
DE SubName: Full=Putative glutamate-gated kainate-type ion channel receptor subunit glur5 {ECO:0000313|EMBL:MBC1172051.1};
OS Lutzomyia longipalpis (Sand fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Psychodoidea; Psychodidae;
OC Lutzomyia; Lutzomyia.
OX NCBI_TaxID=7200 {ECO:0000313|EnsemblMetazoa:LLOJ005443-PA, ECO:0000313|Proteomes:UP000092461};
RN [1] {ECO:0000313|Proteomes:UP000092461}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Jacobina {ECO:0000313|Proteomes:UP000092461};
RA Richards S., Qu C., Dillon R., Worley K., Scherer S., Batterton M.,
RA Taylor A., Hawes A., Hernandez B., Kovar C., Mandapat C., Pham C., Qu C.,
RA Jing C., Bess C., Bandaranaike D., Ngo D., Ongeri F., Arias F., Lara F.,
RA Weissenberger G., Kamau G., Han H., Shen H., Dinh H., Khalil I., Jones J.,
RA Shafer J., Jayaseelan J., Quiroz J., Blankenburg K., Nguyen L., Jackson L.,
RA Francisco L., Tang L.-Y., Pu L.-L., Perales L., Lorensuhewa L.,
RA Munidasa M., Coyle M., Taylor M., Puazo M., Firestine M., Scheel M.,
RA Javaid M., Wang M., Li M., Tabassum N., Saada N., Osuji N., Aqrawi P.,
RA Fu Q., Thornton R., Raj R., Goodspeed R., Mata R., Najjar R., Gubbala S.,
RA Lee S., Denson S., Patil S., Macmil S., Qi S., Matskevitch T.,
RA Palculict T., Mathew T., Vee V., Velamala V., Korchina V., Cai W., Liu W.,
RA Dai W., Zou X., Zhu Y., Zhang Y., Wu Y.-Q., Xin Y., Nazarath L., Kovar C.,
RA Han Y., Muzny D., Gibbs R.;
RT "Whole Genome Assembly of Lutzomyia longipalpis.";
RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:MBC1172051.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Jacobina {ECO:0000313|EMBL:MBC1172051.1};
RC TISSUE=Midgut {ECO:0000313|EMBL:MBC1172051.1};
RA Coutinho-Abreu I.V., Serafim T.D., Meneses C., Kamhawi S., Oliveira F.,
RA Valenzuela J.G.;
RT "Leishmania infection induces a limited differential gene expression in the
RT sand fly midgut.";
RL BMC 21:608-608(2020).
RN [3] {ECO:0000313|EnsemblMetazoa:LLOJ005443-PA}
RP IDENTIFICATION.
RC STRAIN=Jacobina {ECO:0000313|EnsemblMetazoa:LLOJ005443-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|ARBA:ARBA00008685}.
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DR EMBL; AJWK01017210; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJWK01017211; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GITU01003348; MBC1172051.1; -; Transcribed_RNA.
DR AlphaFoldDB; A0A1B0CLF6; -.
DR EnsemblMetazoa; LLOJ005443-RA; LLOJ005443-PA; LLOJ005443.
DR VEuPathDB; VectorBase:LLOJ005443; -.
DR OrthoDB; 3108846at2759; -.
DR Proteomes; UP000092461; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0050906; P:detection of stimulus involved in sensory perception; IEA:UniProt.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR PANTHER; PTHR42643; IONOTROPIC RECEPTOR 20A-RELATED; 1.
DR PANTHER; PTHR42643:SF13; IONOTROPIC RECEPTOR 20A-RELATED; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:MBC1172051.1}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..832
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5033265375"
FT TRANSMEM 536..555
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 604..630
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 796..817
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 537..803
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00060"
SQ SEQUENCE 832 AA; 96204 MW; 9FCD405FF650990D CRC64;
MPERFLRIFL FLFVVEVNFL AKKCSADDFP SLITANASMA IILDQEYLDA RYDAVFTEVQ
NIIERVLRED LKNGGLYVTY YSWTSINLKK DYMAVLMISN CDNTWKVFSE ARQETLLLIA
MTDPDCPRLP PTEAIMVPLT SHGEELPQVL LDLKSSQALR WKSTIVLHDD TFARDMISRV
AIAVTTESPD GYVKPMSVSL FKIRAHIQEW ERRKSIRRTL LSLPTNYIGR NFLVIVTTTI
MENIMEVAKD LGMVEPFSQW MYIISDTNAQ KQNISSVLPL IGEGENVAFA YNVTGLDSNC
KAGILCHSAE LLRSFVLALS KMIREEKAVY GQISDEEWET IRLTKKERRD SLLAYMVNHL
KTTSVCSNCT AWKIQAAEYW GTEYQTNVDN KVPQNYVEEE WNIVNTENRV RKFLDVGTWK
PNDGVQLNDV LFPHVFHGFR GKNLHIVTYH NPPWQIIGYN ESGIPGTMRG LVIDILNEMS
KKLNFTYTMH VISVTVARVN DTEELSYNVR KRKLSFMFMS LQQPLFMIFH PQLSCITWVC
LAACLILMGP FLYIINRFSP FYEQQGYDIT RLGLNRINNC FWYIYGALLQ QGGMYLPQAD
SGRIIIGTWW LVVIVLVTTY CGNLVAFLTF PKIEIPITTL EKTGAVSWST KIREVFFEEF
LVETDEPKYK RLLDGMTFNT ETSAETIESV RRGRHVYIDW KSNLQYIMKK EFLINDRCDF
ALGIEDFLDE QIAIIMPLDS AYLNLINTEI NRLHQMGFIQ RWLKEYLPKK DRCWNVGKAI
EVNNHTVNLD DMQGSFLVLF IGCVLGLCVI VLECMWFKRR ILKEQIIIKP FV
//
