ID A0A1B0CPY8_LUTLO Unreviewed; 1451 AA.
AC A0A1B0CPY8;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Putative rb retinoblastoma tumor suppressor-related protein {ECO:0000313|EMBL:MBC1176377.1};
OS Lutzomyia longipalpis (Sand fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Psychodoidea; Psychodidae;
OC Lutzomyia; Lutzomyia.
OX NCBI_TaxID=7200 {ECO:0000313|EnsemblMetazoa:LLOJ006937-PA, ECO:0000313|Proteomes:UP000092461};
RN [1] {ECO:0000313|Proteomes:UP000092461}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Jacobina {ECO:0000313|Proteomes:UP000092461};
RA Richards S., Qu C., Dillon R., Worley K., Scherer S., Batterton M.,
RA Taylor A., Hawes A., Hernandez B., Kovar C., Mandapat C., Pham C., Qu C.,
RA Jing C., Bess C., Bandaranaike D., Ngo D., Ongeri F., Arias F., Lara F.,
RA Weissenberger G., Kamau G., Han H., Shen H., Dinh H., Khalil I., Jones J.,
RA Shafer J., Jayaseelan J., Quiroz J., Blankenburg K., Nguyen L., Jackson L.,
RA Francisco L., Tang L.-Y., Pu L.-L., Perales L., Lorensuhewa L.,
RA Munidasa M., Coyle M., Taylor M., Puazo M., Firestine M., Scheel M.,
RA Javaid M., Wang M., Li M., Tabassum N., Saada N., Osuji N., Aqrawi P.,
RA Fu Q., Thornton R., Raj R., Goodspeed R., Mata R., Najjar R., Gubbala S.,
RA Lee S., Denson S., Patil S., Macmil S., Qi S., Matskevitch T.,
RA Palculict T., Mathew T., Vee V., Velamala V., Korchina V., Cai W., Liu W.,
RA Dai W., Zou X., Zhu Y., Zhang Y., Wu Y.-Q., Xin Y., Nazarath L., Kovar C.,
RA Han Y., Muzny D., Gibbs R.;
RT "Whole Genome Assembly of Lutzomyia longipalpis.";
RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:MBC1176377.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Jacobina {ECO:0000313|EMBL:MBC1176377.1};
RC TISSUE=Midgut {ECO:0000313|EMBL:MBC1176377.1};
RA Coutinho-Abreu I.V., Serafim T.D., Meneses C., Kamhawi S., Oliveira F.,
RA Valenzuela J.G.;
RT "Leishmania infection induces a limited differential gene expression in the
RT sand fly midgut.";
RL BMC 21:608-608(2020).
RN [3] {ECO:0000313|EnsemblMetazoa:LLOJ006937-PA}
RP IDENTIFICATION.
RC STRAIN=Jacobina {ECO:0000313|EnsemblMetazoa:LLOJ006937-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC {ECO:0000256|ARBA:ARBA00009475}.
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DR EMBL; AJWK01022876; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJWK01022877; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJWK01022878; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJWK01022879; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GITU01007674; MBC1176377.1; -; Transcribed_RNA.
DR EnsemblMetazoa; LLOJ006937-RA; LLOJ006937-PA; LLOJ006937.
DR VEuPathDB; VectorBase:LLOJ006937; -.
DR OrthoDB; 519973at2759; -.
DR Proteomes; UP000092461; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051172; P:negative regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR Gene3D; 1.10.472.140; -; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 4.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR002720; RB_A.
DR InterPro; IPR002719; RB_B.
DR InterPro; IPR028309; RB_fam.
DR InterPro; IPR024599; RB_N.
DR PANTHER; PTHR13742:SF36; RE32990P-RELATED; 1.
DR PANTHER; PTHR13742; RETINOBLASTOMA-ASSOCIATED PROTEIN RB -RELATED; 1.
DR Pfam; PF11934; DUF3452; 1.
DR Pfam; PF01858; RB_A; 2.
DR Pfam; PF01857; RB_B; 2.
DR SMART; SM01367; DUF3452; 1.
DR SMART; SM01368; RB_A; 2.
DR SUPFAM; SSF47954; Cyclin-like; 4.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 63..207
FT /note="Retinoblastoma-associated protein N-terminal"
FT /evidence="ECO:0000259|SMART:SM01367"
FT DOMAIN 365..548
FT /note="Retinoblastoma-associated protein A-box"
FT /evidence="ECO:0000259|SMART:SM01368"
FT DOMAIN 941..1124
FT /note="Retinoblastoma-associated protein A-box"
FT /evidence="ECO:0000259|SMART:SM01368"
FT REGION 335..354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 911..936
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1342..1368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1451 AA; 164922 MW; 7F9424E6ABB1FB2C CRC64;
MESNSESNEL SKDFKEICLK LNMDAETEER AWSSYTSIRD NYTLEGDPLH WLCCALVIAC
RDSYTRTVGS QNNLVQGNCV SLSSVLRNCN TGFRDFFDKI KTWCDMASVP EVTRKRFERL
NDSFTVSSVV YKKFGPLFQQ VFNCPPNEEA RHGKSKKAKN VPCSAVKLFE FAWKLYVCVR
AEEPNESVDL VTSYHLVLTC VNLIYSNVIA ENRRDLVNTS FSGVPGNWNS SNFDAKSISP
LCVMNKLCER DPDTLVEALH IQKVKWNRII KSFFEKGILH GDSETFLDLI SIANFDNNFR
SIGNTYEQYV HSCGEIDETI FLNCAQTGSL NYGGKVRDEN PRENTLDPGT PVTRRNMLPP
KENLSPITSA AMSVKKLKNQ LGSVDAYPHA SLRDSFKTCS VDPMQKILEI LGRMERQFTE
KFPRWPVDRL TLTKTLFYRL LENIVRDEEA KKKTSAKHVY SSEVIIVRLM AISVEIVLRA
YNCTHELFPW ILDCFDLTAF EFYGIIELVV RAGEEFFTRE IIKHLNFVEE QCLEELVWKS
QSPLWGKLID VDKSKLSWQA VDLRAFAADD LTGIAPHSAP LMRIDTQNTP GLTAGGASTS
RVLSGGESHN REAAIRKQLF RSDSGSNLDV NGSAASTAAT VVEQRQQTPL RMLPDAMDDA
TVTPRKRQSL VTFFRKFHKL AFHRMKFIYN QLGLNDPNNL RKIWTIFEHS VLNYTELMKE
RHMDQILMCA IYVFIRVQKL DNTFKDIMQA YRHQPQSASH IYRNVFIKYT GNGVSDNGVP
AVHEAPTPQR PAQPNELAGV PGNWNSSNFD AKSISPLCVM NKLCERDPDT LVEALHIQKV
KWNRIIKSFF EKGILHGDSE TFLDLISIAN FDNNFRSIGN TYEQYVHSCG EIDETIFLNC
AQTGSLNYGG KVRDENPREN TLDPGTPVTR RNMLPPKENL SPITSAAMSV KKLKNQLGSV
DAYPHASLRD SFKTCSVDPM QKILEILGRM ERQFTEKFPR WPVDRLTLTK TLFYRLLENI
VRDEEAKKKT SAKHVYSSEV IIVRLMAISV EIVLRAYNCT HELFPWILDC FDLTAFEFYG
IIELVVRAGE EFFTREIIKH LNFVEEQCLE ELVWKSQSPL WGKLIDVDKS KLSWQAVDLR
AFAADDLTGI APHSAPLMRI DTQNTPGLTA GGASTSRVLS GGESHNREAA IRKQLFRSDS
GSNLDVNGSA ASTAATVVEQ RQQTPLRVLP DAMDDATMTP RKRQSLVIFF RKFHKLAFHR
MKFIYNQLGL NDPNNLRKIW TIFEHSVLNY TELMKERHMD QILMCAIYDI MQAYRHQPQS
ASHIYRNVFI KYTGNGVSDN GVPAVHEAPT PQRPAQPNEL AGTSTSHEKE ERGDIIKFYN
GVYVVKMQQF AINFSTTATN QMLLSPVPNA HSTMCSPRKV SDRVFVQNLD NKDHLMSPGS
HIVSVFDSPS K
//
