ID A0A1B0CTR2_LUTLO Unreviewed; 1293 AA.
AC A0A1B0CTR2;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Putative fibrillin {ECO:0000313|EMBL:MBC1171801.1};
OS Lutzomyia longipalpis (Sand fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Psychodoidea; Psychodidae;
OC Lutzomyia; Lutzomyia.
OX NCBI_TaxID=7200 {ECO:0000313|EnsemblMetazoa:LLOJ008262-PA, ECO:0000313|Proteomes:UP000092461};
RN [1] {ECO:0000313|Proteomes:UP000092461}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Jacobina {ECO:0000313|Proteomes:UP000092461};
RA Richards S., Qu C., Dillon R., Worley K., Scherer S., Batterton M.,
RA Taylor A., Hawes A., Hernandez B., Kovar C., Mandapat C., Pham C., Qu C.,
RA Jing C., Bess C., Bandaranaike D., Ngo D., Ongeri F., Arias F., Lara F.,
RA Weissenberger G., Kamau G., Han H., Shen H., Dinh H., Khalil I., Jones J.,
RA Shafer J., Jayaseelan J., Quiroz J., Blankenburg K., Nguyen L., Jackson L.,
RA Francisco L., Tang L.-Y., Pu L.-L., Perales L., Lorensuhewa L.,
RA Munidasa M., Coyle M., Taylor M., Puazo M., Firestine M., Scheel M.,
RA Javaid M., Wang M., Li M., Tabassum N., Saada N., Osuji N., Aqrawi P.,
RA Fu Q., Thornton R., Raj R., Goodspeed R., Mata R., Najjar R., Gubbala S.,
RA Lee S., Denson S., Patil S., Macmil S., Qi S., Matskevitch T.,
RA Palculict T., Mathew T., Vee V., Velamala V., Korchina V., Cai W., Liu W.,
RA Dai W., Zou X., Zhu Y., Zhang Y., Wu Y.-Q., Xin Y., Nazarath L., Kovar C.,
RA Han Y., Muzny D., Gibbs R.;
RT "Whole Genome Assembly of Lutzomyia longipalpis.";
RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:MBC1171801.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Jacobina {ECO:0000313|EMBL:MBC1171801.1};
RC TISSUE=Midgut {ECO:0000313|EMBL:MBC1171801.1};
RA Coutinho-Abreu I.V., Serafim T.D., Meneses C., Kamhawi S., Oliveira F.,
RA Valenzuela J.G.;
RT "Leishmania infection induces a limited differential gene expression in the
RT sand fly midgut.";
RL BMC 21:608-608(2020).
RN [3] {ECO:0000313|EnsemblMetazoa:LLOJ008262-PA}
RP IDENTIFICATION.
RC STRAIN=Jacobina {ECO:0000313|EnsemblMetazoa:LLOJ008262-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AJWK01027857; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJWK01027858; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJWK01027859; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJWK01027860; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJWK01027861; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJWK01027862; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GITU01003098; MBC1171801.1; -; Transcribed_RNA.
DR EnsemblMetazoa; LLOJ008262-RA; LLOJ008262-PA; LLOJ008262.
DR VEuPathDB; VectorBase:LLOJ008262; -.
DR OrthoDB; 354414at2759; -.
DR Proteomes; UP000092461; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00033; CCP; 3.
DR CDD; cd00054; EGF_CA; 3.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 3.
DR Gene3D; 2.10.25.10; Laminin; 13.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR003410; HYR_dom.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR24034; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24034:SF166; VACUOLAR-SORTING RECEPTOR 1; 1.
DR Pfam; PF12662; cEGF; 2.
DR Pfam; PF07645; EGF_CA; 6.
DR Pfam; PF14670; FXa_inhibition; 2.
DR Pfam; PF02494; HYR; 1.
DR Pfam; PF00084; Sushi; 3.
DR SMART; SM00032; CCP; 4.
DR SMART; SM00181; EGF; 11.
DR SMART; SM00179; EGF_CA; 10.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 4.
DR PROSITE; PS01186; EGF_2; 5.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS01187; EGF_CA; 4.
DR PROSITE; PS50825; HYR; 1.
DR PROSITE; PS50923; SUSHI; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT DOMAIN 16..76
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 746..789
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 831..871
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 913..957
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1014..1064
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1212..1293
FT /note="HYR"
FT /evidence="ECO:0000259|PROSITE:PS50825"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 70..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 246..328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 452..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 504..523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 579..600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..105
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..274
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 275..299
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..326
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 466..485
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1035..1062
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 1293 AA; 142636 MW; 40B2358007B668CD CRC64;
MSPRHHLPDN VNGQYFDCEQ PPPVEHASST LSVDDAEDSV AARYTCDPGF ELQGQPDLFC
DLDTDEWQGQ LPTCRPSDDA RASEGATGDH QQQRKRLRNQ NIQEETAVDD DLASQLDLSC
MGGQSAVKPP NIENAYVNIQ EETAVDDDLA SQLDLSCMGG QSAVKPPNIE NAYVVKFNRR
RKGDNIFLVA FYECEDYHEL KDPHVDRMYC SRQAWVGTKP ECVYVEDGED GEDDYDDTRY
DDEISQEIHS NEAIHPEDVV EEGEEEEYDY EHENQEIAEE VQPPEQHEVV TESHRIEEET
PSPSTAAPST EPPAPTEPPY IQPTTPFDPS CGPDRGGCDH ECRRVRLDHG HESHVECSCF
PGYELNVRDG RTCNDIDECA IRNGGCEQHC RNVAGSFECF CEEGLQIDTA NGRSCIDINE
CLDETIAAQC PYGCENVHGS YRCLEPPTTT TTEAASLPVS VSPEYEERPQ EGEDPLRGDH
RREEDEYEGP DEDDIYGEYE ERNNEVEGVH PEQAPPQEHA CPEGFNRNAQ GECEDINECE
DLHQGGRCPY GCVNVEGSYY CADPPPPTTT EAVAPVVEAS EASEVTSEQT TPAPPSPCGD
GFRRNSDGYC EDIDECQESH TGCDFCKNVH GGFECYCPPG YEMGADEKTC NDINECEIYG
QGSEGSSVLC SHLCENTPGS FACLCPEDYH LDYDRRTCVK DSCADLAASG KTLCSHSCID
NGDGHYTCQC PPGFSLSSDQ KTCIETVDPC SGHAACHPGR CFPVEDYSGS HSFRCDCPAG
YTEKHQRCLD VDECASGSVS CTHGCRNTEG GYQCVCPAGF ELAEDGATCL DQDECLGENP
CGSLRCVNTL GSYKCVCPEG QELHSDGLTC TSADPCAQDN GGCSHQCNSH SGVVFCSCPG
GFELGSDGKT CRDVDECASP TRGGCDSSNG ACVNSAGSYS CLCRPGFELS ADNHTCRSLN
PCDSAGCGHY CDVNDRGEPT CSCRIGFKLD RDRKSCLEIR DLCPPIKAPQ YGEMRCSRPR
HPTQYFYRTR CSIWCQKGYK LDGASVRTCN GTGMWDAEEP TCVPRACPRL PRPQFGTIFP
TSCMLNGSAT GDRCLIHCFP GFKPAGKRSA LCDAQQNWTP TLEAENRVEI VRPFIRCPED
VTVVAPKGQT AFNIRLQRPQ TNVDWWKYVD THPEWAKHLE GTVPLGVTEI TFRARSPNAN
LNEICRMKVT VKEQQPPEVT FCPESIAVQL EEGETFKAVF WKEPTFSSHS HLKQIYKSRQ
PGERFAPGVH FVTYVATDFE GMSSKCSFRI VVK
//
