ID A0A1B0CUN1_LUTLO Unreviewed; 732 AA.
AC A0A1B0CUN1;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=SH3 domain-containing protein {ECO:0000259|PROSITE:PS50002};
OS Lutzomyia longipalpis (Sand fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Psychodoidea; Psychodidae;
OC Lutzomyia; Lutzomyia.
OX NCBI_TaxID=7200 {ECO:0000313|EnsemblMetazoa:LLOJ008666-PA, ECO:0000313|Proteomes:UP000092461};
RN [1] {ECO:0000313|Proteomes:UP000092461}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Jacobina {ECO:0000313|Proteomes:UP000092461};
RA Richards S., Qu C., Dillon R., Worley K., Scherer S., Batterton M.,
RA Taylor A., Hawes A., Hernandez B., Kovar C., Mandapat C., Pham C., Qu C.,
RA Jing C., Bess C., Bandaranaike D., Ngo D., Ongeri F., Arias F., Lara F.,
RA Weissenberger G., Kamau G., Han H., Shen H., Dinh H., Khalil I., Jones J.,
RA Shafer J., Jayaseelan J., Quiroz J., Blankenburg K., Nguyen L., Jackson L.,
RA Francisco L., Tang L.-Y., Pu L.-L., Perales L., Lorensuhewa L.,
RA Munidasa M., Coyle M., Taylor M., Puazo M., Firestine M., Scheel M.,
RA Javaid M., Wang M., Li M., Tabassum N., Saada N., Osuji N., Aqrawi P.,
RA Fu Q., Thornton R., Raj R., Goodspeed R., Mata R., Najjar R., Gubbala S.,
RA Lee S., Denson S., Patil S., Macmil S., Qi S., Matskevitch T.,
RA Palculict T., Mathew T., Vee V., Velamala V., Korchina V., Cai W., Liu W.,
RA Dai W., Zou X., Zhu Y., Zhang Y., Wu Y.-Q., Xin Y., Nazarath L., Kovar C.,
RA Han Y., Muzny D., Gibbs R.;
RT "Whole Genome Assembly of Lutzomyia longipalpis.";
RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:LLOJ008666-PA}
RP IDENTIFICATION.
RC STRAIN=Jacobina {ECO:0000313|EnsemblMetazoa:LLOJ008666-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC {ECO:0000256|ARBA:ARBA00004246}.
CC -!- SIMILARITY: Belongs to the CAS family. {ECO:0000256|ARBA:ARBA00007848}.
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DR EMBL; AJWK01029422; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJWK01029423; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJWK01029424; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJWK01029425; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJWK01029426; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A1B0CUN1; -.
DR EnsemblMetazoa; LLOJ008666-RA; LLOJ008666-PA; LLOJ008666.
DR VEuPathDB; VectorBase:LLOJ008666; -.
DR OrthoDB; 3030146at2759; -.
DR Proteomes; UP000092461; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd11564; FAT-like_CAS_C; 1.
DR CDD; cd11549; Serine_rich_CAS; 1.
DR Gene3D; 1.20.120.230; Alpha-catenin/vinculin-like; 1.
DR Gene3D; 1.20.120.830; Serine-rich domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR021901; CAS_C.
DR InterPro; IPR037362; CAS_fam.
DR InterPro; IPR014928; Serine_rich_dom.
DR InterPro; IPR038319; Serine_rich_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR10654; CAS SCAFFOLDING PROTEIN; 1.
DR PANTHER; PTHR10654:SF18; IP17195P; 1.
DR Pfam; PF12026; CAS_C; 1.
DR Pfam; PF08824; Serine_rich; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 40..117
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 9..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 283..311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 732 AA; 80237 MW; 6E4BCA8C11232409 CRC64;
MAFLSLSFVT TPRGRTPTST GPRTPSDLDY DVPVSRRHVT KPTYARAIYD NIAESPDELA
FKRGDILTVI EQDTDGLTGW WLCKLRGRQT IAHELGRMAY GDAVKYLAPE FLTVMGKKFT
FSESDIEKGI CPGNRLRTVQ SYDSGCCSPS PISSPCPSIG SSSSLYANHT THVSNPSELY
ENTSVARLQK HGKRRSWHIM PNKVVTPQKC GDVYLYDLLP TPQRGSGFLG GTTVMSGDTS
ETYDVPKPAV PVNYDVPRVW HSPRGRPEDC CYDIPRPVTL LSQKDLTPSS SNSSLLTSDS
LSLSSSNRSS LANMTDYDVP RRVARASPHP SSMSISTASL QLNYDVPIPH SPQNHTLQLS
TCKELPLELG SALDTLAKLQ TEATNAVTRL LAFVSPQWRT KEKLDPILMD LKLAAVRLRT
ALHDLAEFGE GALGNTAKAD DKGLSIKLRP LVRALKDADR LVHEASHCID IQGWTLETLT
RAEIKAGTQL PPDSLDQLIA CAQTLTEDVR QTASFIQGNA TLLFKRISPS VTPQTPSNNN
NGDWPEDYDY VCLESKEASA RKNAEIRDAL PSDLQKNFEN VVKNAESAAI GATAGTELDP
NDKTLLVYYA AQTVTHMNYL TQAIDAFLQT VEHNQPPKFF LAHGKFVVLS AHNLVNIGDI
VHRNVTKQDV RGNILQCADA LSDGMKACVA KTKKAAQHFP SVNAVQEMVD SVVDISHLAS
DLKIAMLRAV QQ
//
