ID A0A1B0CY84_LUTLO Unreviewed; 651 AA.
AC A0A1B0CY84;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Putative patched domain-containing protein 3-like aedes albopictus {ECO:0000313|EMBL:MBC1175141.1};
OS Lutzomyia longipalpis (Sand fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Psychodoidea; Psychodidae;
OC Lutzomyia; Lutzomyia.
OX NCBI_TaxID=7200 {ECO:0000313|EnsemblMetazoa:LLOJ010083-PA, ECO:0000313|Proteomes:UP000092461};
RN [1] {ECO:0000313|Proteomes:UP000092461}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Jacobina {ECO:0000313|Proteomes:UP000092461};
RA Richards S., Qu C., Dillon R., Worley K., Scherer S., Batterton M.,
RA Taylor A., Hawes A., Hernandez B., Kovar C., Mandapat C., Pham C., Qu C.,
RA Jing C., Bess C., Bandaranaike D., Ngo D., Ongeri F., Arias F., Lara F.,
RA Weissenberger G., Kamau G., Han H., Shen H., Dinh H., Khalil I., Jones J.,
RA Shafer J., Jayaseelan J., Quiroz J., Blankenburg K., Nguyen L., Jackson L.,
RA Francisco L., Tang L.-Y., Pu L.-L., Perales L., Lorensuhewa L.,
RA Munidasa M., Coyle M., Taylor M., Puazo M., Firestine M., Scheel M.,
RA Javaid M., Wang M., Li M., Tabassum N., Saada N., Osuji N., Aqrawi P.,
RA Fu Q., Thornton R., Raj R., Goodspeed R., Mata R., Najjar R., Gubbala S.,
RA Lee S., Denson S., Patil S., Macmil S., Qi S., Matskevitch T.,
RA Palculict T., Mathew T., Vee V., Velamala V., Korchina V., Cai W., Liu W.,
RA Dai W., Zou X., Zhu Y., Zhang Y., Wu Y.-Q., Xin Y., Nazarath L., Kovar C.,
RA Han Y., Muzny D., Gibbs R.;
RT "Whole Genome Assembly of Lutzomyia longipalpis.";
RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:MBC1175141.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Jacobina {ECO:0000313|EMBL:MBC1175141.1};
RC TISSUE=Midgut {ECO:0000313|EMBL:MBC1175141.1};
RA Coutinho-Abreu I.V., Serafim T.D., Meneses C., Kamhawi S., Oliveira F.,
RA Valenzuela J.G.;
RT "Leishmania infection induces a limited differential gene expression in the
RT sand fly midgut.";
RL BMC 21:608-608(2020).
RN [3] {ECO:0000313|EnsemblMetazoa:LLOJ010083-PA}
RP IDENTIFICATION.
RC STRAIN=Jacobina {ECO:0000313|EnsemblMetazoa:LLOJ010083-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
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DR EMBL; AJWK01035577; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJWK01035578; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJWK01035579; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJWK01035580; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GITU01006438; MBC1175141.1; -; Transcribed_RNA.
DR AlphaFoldDB; A0A1B0CY84; -.
DR EnsemblMetazoa; LLOJ010083-RA; LLOJ010083-PA; LLOJ010083.
DR VEuPathDB; VectorBase:LLOJ010083; -.
DR OrthoDB; 2876883at2759; -.
DR Proteomes; UP000092461; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 1.
DR InterPro; IPR003392; Ptc/Disp.
DR PANTHER; PTHR10796; PATCHED-RELATED; 1.
DR PANTHER; PTHR10796:SF92; PATCHED-RELATED, ISOFORM A; 1.
DR Pfam; PF02460; Patched; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 47..69
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 256..274
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 280..301
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 313..332
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 347..371
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 383..405
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 465..496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 578..651
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 578..609
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 615..643
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 651 AA; 74974 MW; 1C61698BC606DB9E CRC64;
MEKRSCLYRV LMSGGINRDD PDNPVDNREH MLMAFFKNRV ASLLNKAWMK AFVIIVFGAY
LLGACFGLTN IEEGLERRKL SKADSYSVEF FDREDEFYRE FPYRIQVIIT GDLNYSDPVV
QNQIETLTQN LENTSYVTTS LYTESWIRSF LSYVERNGDY LNVTIDSEQT FIEALKELWL
FPGNPFSLDV KFNEDGTKIL ASRFLIQAVN ISGTNHEKTM VKDLRKICHD SPLNATVFHP
YFVFFDQFEL VRPTSIQSMV IGAIIMMLIS FIFIPNILCS LWVAFSIVSI ELGVAGYMAL
WDVNLDSISM INLIMCIGFS VDFTAHICYT YMSSKAKNPD DRVREALYSL GLPICQGSFS
TILGVVALLL ADSYIFLVFF KMVFLVIFFG AMHGLFLLPV LLSLFGPGSC GSPKSAEKEM
KLSAVEKSYP HPYCIPHPQL ALTGPFGSKN FLGAPYKAYG DDKDLGIGTS GEDSSESSSS
KSQRRQAIED ENTRRRYEEG WRRSWHNVAA NGGSTPSQFQ PPVLDLYGHE TERLWTTGRR
YYDDTYLTQR RNDSTYRRNS DEKATQYRAK YGEHDDLRYF YEPDTQRRRY SDETKRRVSD
ERRPRRYSPP EGIYKPNPNR STSQHNLYYP RQPQRTNSQH SLRHMGDMRF P
//
