ID A0A1B0D0V8_PHLPP Unreviewed; 518 AA.
AC A0A1B0D0V8;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=Cysteine protease {ECO:0000256|RuleBase:RU363115};
DE EC=3.4.22.- {ECO:0000256|RuleBase:RU363115};
OS Phlebotomus papatasi (Sandfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Psychodoidea; Psychodidae;
OC Phlebotomus; Phlebotomus.
OX NCBI_TaxID=29031 {ECO:0000313|EnsemblMetazoa:PPAI000982-PA, ECO:0000313|Proteomes:UP000092462};
RN [1] {ECO:0000313|Proteomes:UP000092462}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Israel {ECO:0000313|Proteomes:UP000092462};
RA Fulton L., Warren W., Minx P., Wilson R., Clifton S., Abrudan J.,
RA Ramalho-Ortigao M., Lawyer P., Kamhawi S., Rowton E., Lehane M., Bates P.,
RA Valenzeula J., Dillon R., Lobo N., Collins F., McDowell M.A.;
RT "Phlebotomus papatasi, whole genome shotgun sequencing project.";
RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:PPAI000982-PA}
RP IDENTIFICATION.
RC STRAIN=Israel {ECO:0000313|EnsemblMetazoa:PPAI000982-PA};
RG EnsemblMetazoa;
RL Submitted (AUG-2022) to UniProtKB.
CC -!- FUNCTION: Cysteine protease that plays a key role in autophagy by
CC mediating both proteolytic activation and delipidation of ATG8 family
CC proteins. {ECO:0000256|RuleBase:RU363115}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU363115}.
CC -!- SIMILARITY: Belongs to the asteroid family.
CC {ECO:0000256|ARBA:ARBA00007398}.
CC -!- SIMILARITY: Belongs to the peptidase C54 family.
CC {ECO:0000256|RuleBase:RU363115}.
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DR EMBL; AJVK01021727; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A1B0D0V8; -.
DR EnsemblMetazoa; PPAI000982-RA; PPAI000982-PA; PPAI000982.
DR VEuPathDB; VectorBase:PPAI000982; -.
DR OrthoDB; 2943058at2759; -.
DR Proteomes; UP000092462; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0019786; F:protein-phosphatidylethanolamide deconjugating activity; IEA:InterPro.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR InterPro; IPR026832; Asteroid.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR046792; Peptidase_C54_cat.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR PANTHER; PTHR15665; ASTEROID PROTEIN; 1.
DR PANTHER; PTHR15665:SF1; PROTEIN ASTEROID HOMOLOG 1; 1.
DR Pfam; PF03416; Peptidase_C54; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
PE 3: Inferred from homology;
KW Autophagy {ECO:0000256|RuleBase:RU363115};
KW Cytoplasm {ECO:0000256|RuleBase:RU363115};
KW Hydrolase {ECO:0000256|RuleBase:RU363115};
KW Protease {ECO:0000256|RuleBase:RU363115};
KW Protein transport {ECO:0000256|RuleBase:RU363115};
KW Transport {ECO:0000256|RuleBase:RU363115}.
FT DOMAIN 291..449
FT /note="Peptidase C54 catalytic"
FT /evidence="ECO:0000259|Pfam:PF03416"
SQ SEQUENCE 518 AA; 60273 MW; 55A52FF4F25BAEA9 CRC64;
MGVKGLTTYI AKNAKKFLVP HELHDCNLVI DGDNLACQLF KKICSTTNCA FGGDYDMFYM
QVCRFFILLD KCNVKSYVLL DGGYEEYRLR TVHTRLRSKI ASIKHIDPSR PDTIHFPLLI
REVFVRALKD MGIKVMRCLF EADEEVANLA RRLDCPVLSY DSDFYIYNVL YIPFVSLTFK
VYKKIIQRDG NQMIRTERCS MKARKRNRKA RVPIMDIDGD ENEPEDDSTE ECYYYLDCCL
YQMENLLKYT KLTEELLPFF GAIVGNDFTQ QSKLKKFYSG HKQNTYKKNI IMLKLLKYDD
WSSLAIHVAL DNVIYLDDIK ELCCDDDDKS WKPLLLIVPL RLGINEINPI YIDGLKRCFE
INRNMGMIGG KPNQALYFIG YVGDEVLYLD PHTTQRNGSV GNKQTIEEIE MDETFHQKYA
SRIPFRQMDP SLAVCFLCRT QLEFDELYAR LLQDVLSESH PLFEVIQTRQ QPWPSVASTS
TPSHRRSRNR GDSETDPTLG EFEELDVRQS DEDFEIIA
//