ID   A0A1B0D4N8_PHLPP        Unreviewed;       556 AA.
AC   A0A1B0D4N8;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:PPAI002446-PA};
OS   Phlebotomus papatasi (Sandfly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Psychodoidea; Psychodidae;
OC   Phlebotomus; Phlebotomus.
OX   NCBI_TaxID=29031 {ECO:0000313|EnsemblMetazoa:PPAI002446-PA, ECO:0000313|Proteomes:UP000092462};
RN   [1] {ECO:0000313|Proteomes:UP000092462}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Israel {ECO:0000313|Proteomes:UP000092462};
RA   Fulton L., Warren W., Minx P., Wilson R., Clifton S., Abrudan J.,
RA   Ramalho-Ortigao M., Lawyer P., Kamhawi S., Rowton E., Lehane M., Bates P.,
RA   Valenzeula J., Dillon R., Lobo N., Collins F., McDowell M.A.;
RT   "Phlebotomus papatasi, whole genome shotgun sequencing project.";
RL   Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:PPAI002446-PA}
RP   IDENTIFICATION.
RC   STRAIN=Israel {ECO:0000313|EnsemblMetazoa:PPAI002446-PA};
RG   EnsemblMetazoa;
RL   Submitted (AUG-2022) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC         Evidence={ECO:0000256|ARBA:ARBA00001270};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC       outer membrane {ECO:0000256|ARBA:ARBA00004374}; Multi-pass membrane
CC       protein {ECO:0000256|ARBA:ARBA00004374}.
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DR   EMBL; AJVK01024730; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AJVK01024731; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AJVK01024732; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A1B0D4N8; -.
DR   EnsemblMetazoa; PPAI002446-RA; PPAI002446-PA; PPAI002446.
DR   VEuPathDB; VectorBase:PPAI002446; -.
DR   OrthoDB; 3282693at2759; -.
DR   Proteomes; UP000092462; Unassembled WGS sequence.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0008053; P:mitochondrial fusion; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR045063; Dynamin_N.
DR   InterPro; IPR006884; Fzo/mitofusin_HR2.
DR   InterPro; IPR030381; G_DYNAMIN_dom.
DR   InterPro; IPR027094; Mitofusin_fam.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR10465; TRANSMEMBRANE GTPASE FZO1; 1.
DR   PANTHER; PTHR10465:SF0; TRANSMEMBRANE GTPASE MARF-RELATED; 1.
DR   Pfam; PF00350; Dynamin_N; 1.
DR   Pfam; PF04799; Fzo_mitofusin; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51718; G_DYNAMIN_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|ARBA:ARBA00022989};
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW   Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00022787};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
SQ   SEQUENCE   556 AA;  63390 MW;  B8363A8A3F6FEBD8 CRC64;
     MLREKVLPSG IGHTTNCFCQ VEGVDGHEAY LVKEGSEEKL NVVSVQQLAN ALSQEKLNES
     SLIRIFWPRE RCSLLRDDVV FMDSPGVDVS PNLDDWIDNH CLNADVFVLV LNAESTMTIA
     EKSFFHEVSQ RLSKPNIFIL NNRWDASANE PEFQESVKAQ HTERCIDFLT KELKVSLQKE
     AEERNRYFEF QDFERKFEEC ISKSAVKTKF EQHSRGGKQI AKDMISMLDN IYDRASCLKT
     QKLDHRRILI ERINNTDQQL AQVTREMKSK IHSMVEEVEQ KVSKALNEEI WRLGVLVDEF
     PLPFHTDPVV LNIYKREMNS HVEQGLGSNL RARLSTAMAM NMETAQREMT EKMHSLLPSD
     MLNQKVSSFA VRQQPFEMFY TLNCQNLCAD FQEDLEFRFS WGITAILQKI SNRMKDKKGN
     DKTLMITRQS SQNSLPPVMS PISDQPDGAN CVVPYGGSSI TPEQLSLISN MMVATMGSHG
     TVGGIIVSGL LFKAIGWRVL VGIGVAYGCV YLYERLSYTN SAKKRRFKSQ YVKHATKKLK
     LIVDLTSANC SHQVQQ
//