ID   A0A1B0D4Y4_PHLPP        Unreviewed;       423 AA.
AC   A0A1B0D4Y4;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=Potassium channel inwardly rectifying transmembrane domain-containing protein {ECO:0008006|Google:ProtNLM};
OS   Phlebotomus papatasi (Sandfly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Psychodoidea; Psychodidae;
OC   Phlebotomus; Phlebotomus.
OX   NCBI_TaxID=29031 {ECO:0000313|EnsemblMetazoa:PPAI002542-PA, ECO:0000313|Proteomes:UP000092462};
RN   [1] {ECO:0000313|Proteomes:UP000092462}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Israel {ECO:0000313|Proteomes:UP000092462};
RA   Fulton L., Warren W., Minx P., Wilson R., Clifton S., Abrudan J.,
RA   Ramalho-Ortigao M., Lawyer P., Kamhawi S., Rowton E., Lehane M., Bates P.,
RA   Valenzeula J., Dillon R., Lobo N., Collins F., McDowell M.A.;
RT   "Phlebotomus papatasi, whole genome shotgun sequencing project.";
RL   Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:PPAI002542-PA}
RP   IDENTIFICATION.
RC   STRAIN=Israel {ECO:0000313|EnsemblMetazoa:PPAI002542-PA};
RG   EnsemblMetazoa;
RL   Submitted (AUG-2022) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU003822}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel (TC
CC       1.A.2.1) family. {ECO:0000256|RuleBase:RU003822}.
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DR   EMBL; AJVK01024965; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A1B0D4Y4; -.
DR   EnsemblMetazoa; PPAI002542-RA; PPAI002542-PA; PPAI002542.
DR   VEuPathDB; VectorBase:PPAI002542; -.
DR   OrthoDB; 4126787at2759; -.
DR   Proteomes; UP000092462; Unassembled WGS sequence.
DR   GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 2.60.40.1400; G protein-activated inward rectifier potassium channel 1; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; INWARD RECTIFIER POTASSIUM CHANNEL; 1.
DR   PANTHER; PTHR11767:SF102; INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; E set domains; 1.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU003822};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU003822}; Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Potassium {ECO:0000256|ARBA:ARBA00022958, ECO:0000256|RuleBase:RU003822};
KW   Potassium transport {ECO:0000256|ARBA:ARBA00022538,
KW   ECO:0000256|RuleBase:RU003822};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003822};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003822};
KW   Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW   ECO:0000256|RuleBase:RU003822}.
FT   DOMAIN          155..290
FT                   /note="Inward rectifier potassium channel C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF17655"
FT   DOMAIN          291..408
FT                   /note="Potassium channel inwardly rectifying transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF01007"
SQ   SEQUENCE   423 AA;  47746 MW;  AF15880CE949DA5E CRC64;
     CDQPLRSILH SSRVFKLNFS THTSATLAAL AHSKIANLSP QSINNFVDYT LFNNTYEVDT
     PLCSAKQLDE LRAELNSPNG LERLCSSGLL PRVSSAASLD PASEESGDSG RLQIRSCSVP
     NGIPVAEALH HKINGQKKTQ SGRRLSIKQE ALPTLLFSRN AVICHRDGIP CLMFRVGDMR
     KSHIIEAHVR AQIIRKKVTK ENEVLPFYQQ ELEVGADGKE DRLMFIWPTT IVHKIDKHSP
     LYALSAQDML KERFEIVVML EGVVESTGMT TQARSSYLPS EILWGHRFEQ QRWLMLIFAL
     SFLLSWTAFG IIWWLIAYTH GDLDALEPQD PHVRLIHNKS TNPCVTEIYG FTSCFLFSVE
     TQHTIGYGNR YITEECPEAI FIMCLQSIMG VFIQAFMVGI VFAKLSRPKK RAQLFTLHVI
     SNL
//