ID   A0A1B0D7K2_PHLPP        Unreviewed;       577 AA.
AC   A0A1B0D7K2;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=Choline/carnitine acyltransferase domain-containing protein {ECO:0000259|Pfam:PF00755};
OS   Phlebotomus papatasi (Sandfly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Psychodoidea; Psychodidae;
OC   Phlebotomus; Phlebotomus.
OX   NCBI_TaxID=29031 {ECO:0000313|EnsemblMetazoa:PPAI003525-PA, ECO:0000313|Proteomes:UP000092462};
RN   [1] {ECO:0000313|Proteomes:UP000092462}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Israel {ECO:0000313|Proteomes:UP000092462};
RA   Fulton L., Warren W., Minx P., Wilson R., Clifton S., Abrudan J.,
RA   Ramalho-Ortigao M., Lawyer P., Kamhawi S., Rowton E., Lehane M., Bates P.,
RA   Valenzeula J., Dillon R., Lobo N., Collins F., McDowell M.A.;
RT   "Phlebotomus papatasi, whole genome shotgun sequencing project.";
RL   Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:PPAI003525-PA}
RP   IDENTIFICATION.
RC   STRAIN=Israel {ECO:0000313|EnsemblMetazoa:PPAI003525-PA};
RG   EnsemblMetazoa;
RL   Submitted (AUG-2022) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(R)-carnitine + 4,8-dimethylnonanoyl-CoA = CoA + O-4,8-
CC         dimethylnonanoyl-(R)-carnitine; Xref=Rhea:RHEA:44860,
CC         ChEBI:CHEBI:16347, ChEBI:CHEBI:57287, ChEBI:CHEBI:77061,
CC         ChEBI:CHEBI:84654; Evidence={ECO:0000256|ARBA:ARBA00024283};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|ARBA:ARBA00005005}.
CC   -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00005232}.
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DR   EMBL; AJVK01026977; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A1B0D7K2; -.
DR   EnsemblMetazoa; PPAI003525-RA; PPAI003525-PA; PPAI003525.
DR   VEuPathDB; VectorBase:PPAI003525; -.
DR   OrthoDB; 1429709at2759; -.
DR   Proteomes; UP000092462; Unassembled WGS sequence.
DR   GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR   Gene3D; 1.10.275.20; Choline/Carnitine o-acyltransferase; 1.
DR   Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR   InterPro; IPR000542; Carn_acyl_trans.
DR   InterPro; IPR042572; Carn_acyl_trans_N.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR039551; Cho/carn_acyl_trans.
DR   InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR   PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR   PANTHER; PTHR22589:SF16; CARNITINE O-PALMITOYLTRANSFERASE 2, MITOCHONDRIAL; 1.
DR   Pfam; PF00755; Carn_acyltransf; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          53..567
FT                   /note="Choline/carnitine acyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF00755"
SQ   SEQUENCE   577 AA;  64378 MW;  1802021340E47FFB CRC64;
     DIVINCTISS ILVEFRDQSV FRSQITTLPH SNYQFLQRSS VPMLHFQASL PRLPIPELSA
     TCTRYLEAQQ PLLTPEAHAT TTKLTQDFQN GPGKELQVRL KAVDSANKHT SYISEPWFEM
     YLSDRAPLPV NYTPLLGMKL IPAAGTSVAT QVANILITSA RFMRALRARS LAPEVFHLNP
     QTADSALWKT AVKLSPQIGA TYVSYAFKAF PLDMSQYQGL FSATRIPQEG KDKIFRASSD
     PQHVVIMRRG NIYRLDILDR DGNIESPSVI LGRIRRLMAT SEAHDSPQHP LGIMTTQNRN
     QWAQFRQHLE GLSERNRRNL QLLDSGILCV CLDDISYSPE DVTCRVRDYL FSNASNRWFD
     KSLSVTVSKD TRAAITFEHS WGDGVAVLRY FNELYKELST QPIVTDDMEG SANDEAATEL
     LSFDYDDKLK AGIETALKNH SEVENSLDVN YMMSDVGKKH CKAVQVSPDA VAQLTIQLAY
     ALISGGGTTA TYESCSTAAF RCGRTETVRP ATMATRALCQ HLLTSKGHAG PEELALLRQC
     SDKHTKLTKE AAMGQGFDRH LFVLRVEPPR GTGERLQ
//