ID   A0A1B0DLX1_PHLPP        Unreviewed;       607 AA.
AC   A0A1B0DLX1;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:PPAI009361-PA};
OS   Phlebotomus papatasi (Sandfly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Psychodoidea; Psychodidae;
OC   Phlebotomus; Phlebotomus.
OX   NCBI_TaxID=29031 {ECO:0000313|EnsemblMetazoa:PPAI009361-PA, ECO:0000313|Proteomes:UP000092462};
RN   [1] {ECO:0000313|Proteomes:UP000092462}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Israel {ECO:0000313|Proteomes:UP000092462};
RA   Fulton L., Warren W., Minx P., Wilson R., Clifton S., Abrudan J.,
RA   Ramalho-Ortigao M., Lawyer P., Kamhawi S., Rowton E., Lehane M., Bates P.,
RA   Valenzeula J., Dillon R., Lobo N., Collins F., McDowell M.A.;
RT   "Phlebotomus papatasi, whole genome shotgun sequencing project.";
RL   Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:PPAI009361-PA}
RP   IDENTIFICATION.
RC   STRAIN=Israel {ECO:0000313|EnsemblMetazoa:PPAI009361-PA};
RG   EnsemblMetazoa;
RL   Submitted (AUG-2022) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC       {ECO:0000256|ARBA:ARBA00010617}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJVK01016582; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AJVK01016583; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A1B0DLX1; -.
DR   EnsemblMetazoa; PPAI009361-RA; PPAI009361-PA; PPAI009361.
DR   VEuPathDB; VectorBase:PPAI009361; -.
DR   OrthoDB; 2878816at2759; -.
DR   Proteomes; UP000092462; Unassembled WGS sequence.
DR   GO; GO:0005694; C:chromosome; IEA:UniProt.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   Gene3D; 2.30.30.140; -; 1.
DR   Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR   Gene3D; 1.10.274.30; MRG domain; 1.
DR   InterPro; IPR016197; Chromo-like_dom_sf.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   InterPro; IPR008676; MRG.
DR   InterPro; IPR038217; MRG_C_sf.
DR   InterPro; IPR026541; MRG_dom.
DR   InterPro; IPR025995; Tudor-knot.
DR   PANTHER; PTHR10880; MORTALITY FACTOR 4-LIKE PROTEIN; 1.
DR   PANTHER; PTHR10880:SF15; MRG DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF05712; MRG; 1.
DR   Pfam; PF00067; p450; 1.
DR   Pfam; PF11717; Tudor-knot; 1.
DR   SUPFAM; SSF54160; Chromo domain-like; 1.
DR   SUPFAM; SSF48264; Cytochrome P450; 1.
DR   PROSITE; PS51640; MRG; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW   Monooxygenase {ECO:0000256|ARBA:ARBA00023033};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023033};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          12..70
FT                   /note="Tudor-knot"
FT                   /evidence="ECO:0000259|Pfam:PF11717"
FT   DOMAIN          148..432
FT                   /note="MRG"
FT                   /evidence="ECO:0000259|Pfam:PF05712"
SQ   SEQUENCE   607 AA;  69526 MW;  4A2F045D0E3B9EB4 CRC64;
     MVSTRGIKYA FSEGERVLCY EPDPTKAKVL YDSKVLEIFD SRDRRGKRVV EYLIHFQGWN
     SSWDRKVNES FVLKDNIVNR QLQKDLAEKS QLCLGAYLYR KDRKKSKSSG GIEASTEPVT
     LSLPVAGKVE NELQMQDNDT ESYSSSAESG SGQVENEKVI IQVSKTLKQL LEFDHRMITQ
     ESRLSVLPAP LPIVTILEKF VKQCSVKMIC NHIRQDQRKR RNSATRTDSP LDTEKLTNRL
     NLYKEVADGL RIYFDFTLKD HLLYQQERQQ AESVLDEENL KSFTYIPSEK SFTDIIFPSV
     SEKSTPNSST DVTDDTARRR LRSYKLETGA EGESEGAMPF AAAIAEILRS VQPFNASVPF
     RLKILLQNTL AWHLLPSNAP PEPSMIYGAP HLARLLIKLP EFLTHSVGNM SEEKVKYLME
     YLVLLFAFFD YRQKIKRLEG TQFTGPGFLP ILGHAGFFLF KKPSEVLDLV TKGSQEFGKM
     TRVWMVNMLF LGIADPKYVE AILNSPVHIN KAIEYSYLNN WLGDGLLLTT GKKWQTRRKI
     LTPAFHFKIL EYFVEIFDKQ SKIFVEKLEQ FSAKTPVNIC PLISLLTFDV ICAVILRFTQ
     AYTYLND
//