ID   A0A1B0DPA5_PHLPP        Unreviewed;      1009 AA.
AC   A0A1B0DPA5;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   RecName: Full=Phosphoenolpyruvate carboxykinase (GTP) {ECO:0008006|Google:ProtNLM};
OS   Phlebotomus papatasi (Sandfly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Psychodoidea; Psychodidae;
OC   Phlebotomus; Phlebotomus.
OX   NCBI_TaxID=29031 {ECO:0000313|EnsemblMetazoa:PPAI010341-PA, ECO:0000313|Proteomes:UP000092462};
RN   [1] {ECO:0000313|Proteomes:UP000092462}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Israel {ECO:0000313|Proteomes:UP000092462};
RA   Fulton L., Warren W., Minx P., Wilson R., Clifton S., Abrudan J.,
RA   Ramalho-Ortigao M., Lawyer P., Kamhawi S., Rowton E., Lehane M., Bates P.,
RA   Valenzeula J., Dillon R., Lobo N., Collins F., McDowell M.A.;
RT   "Phlebotomus papatasi, whole genome shotgun sequencing project.";
RL   Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:PPAI010341-PA}
RP   IDENTIFICATION.
RC   STRAIN=Israel {ECO:0000313|EnsemblMetazoa:PPAI010341-PA};
RG   EnsemblMetazoa;
RL   Submitted (AUG-2022) to UniProtKB.
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DR   EMBL; AJVK01018164; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AJVK01018165; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A1B0DPA5; -.
DR   EnsemblMetazoa; PPAI010341-RA; PPAI010341-PA; PPAI010341.
DR   VEuPathDB; VectorBase:PPAI010341; -.
DR   OrthoDB; 1112009at2759; -.
DR   Proteomes; UP000092462; Unassembled WGS sequence.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004613; F:phosphoenolpyruvate carboxykinase (GTP) activity; IEA:InterPro.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:InterPro.
DR   Gene3D; 3.90.228.20; -; 2.
DR   Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   Gene3D; 1.20.120.670; N-acetyl-b-d-glucoasminidase; 1.
DR   HAMAP; MF_00452; PEPCK_GTP; 1.
DR   InterPro; IPR029018; Hex-like_dom2.
DR   InterPro; IPR007781; NAGLU.
DR   InterPro; IPR024732; NAGLU_C.
DR   InterPro; IPR024240; NAGLU_N.
DR   InterPro; IPR024733; NAGLU_tim-barrel.
DR   InterPro; IPR018091; PEP_carboxykin_GTP_CS.
DR   InterPro; IPR013035; PEP_carboxykinase_C.
DR   InterPro; IPR008209; PEP_carboxykinase_GTP.
DR   InterPro; IPR035077; PEP_carboxykinase_GTP_C.
DR   PANTHER; PTHR12872; ALPHA-N-ACETYLGLUCOSAMINIDASE; 1.
DR   PANTHER; PTHR12872:SF1; ALPHA-N-ACETYLGLUCOSAMINIDASE; 1.
DR   Pfam; PF05089; NAGLU; 1.
DR   Pfam; PF12972; NAGLU_C; 1.
DR   Pfam; PF12971; NAGLU_N; 1.
DR   Pfam; PF00821; PEPCK_GTP; 1.
DR   SUPFAM; SSF53795; PEP carboxykinase-like; 1.
DR   PROSITE; PS00505; PEPCK_GTP; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801}.
FT   DOMAIN          44..124
FT                   /note="Alpha-N-acetylglucosaminidase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12971"
FT   DOMAIN          138..469
FT                   /note="Alpha-N-acetylglucosaminidase tim-barrel"
FT                   /evidence="ECO:0000259|Pfam:PF05089"
FT   DOMAIN          478..591
FT                   /note="Alpha-N-acetylglucosaminidase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12972"
FT   DOMAIN          645..1003
FT                   /note="Phosphoenolpyruvate carboxykinase C-terminal P-loop"
FT                   /evidence="ECO:0000259|Pfam:PF00821"
SQ   SEQUENCE   1009 AA;  114604 MW;  13A9733B76E96204 CRC64;
     MLCVSETWLD SSDSMDSVGA RDFRFFSFLN NVRSDTPAEE QRDAALEVIS RLIPERAHEF
     TVEINISLPL NTFKISKSDE ADKVQIVASS GISACKGFYH YLKNYCGCHV SWDGDQLALP
     EILPLVKLSR TSPSRFVYYQ NVCTWSYSFA AWTWLDWRRH IDWMALNGIT LSLAPVQEDI
     WTGIYREMGL SEKEIEDHIA GPAFLAWQRM GNIRGVGGPL PELFKGRLAM LQNQSVYEIR
     RLGGMVALPA FAGHVPVALQ RLFPNASYTP VERWNRFTDD ECCPLFLDPS DELFQSIGKT
     FLERIREKYG SDHIYFADPY NEIQPKEANP DYLRKSAQGI FSAMQAVDDK AVWLLQGWMF
     VKNPFWSDEL LESFLTAIPR GRFLVLDLQS EQFPQYERTN SYYGQPFIWC MLHNFGGTLG
     MHGSVNNVNV LVPAARQRVN STMVGVGITP EGINQNYVMY EFALEMAWNF ESVDEEAWFF
     KYASIRYGHV NFQAIDAWQQ LRNSVYSYKG LDKIRGKYTF CRRPSLKLSP WAWYERAMIE
     RAWESLLNAS EGLGSSQLYL HDLVDVTRQA LQNRADEIYL VIIQAYNHQQ TLSKEWLHNF
     SIYSQTSKES SKLLHTSVQM NDPSIPGKKC FALRIGSTIA HREGWLAEHM LILGITNPRG
     EKRYIAAAFP SACGKTNLAM LTPTLPGYKV ECVGDDIAWM KFDSQGQLRA INPENGFFGV
     APGTSMATNP NAMATAFKNT VFTNVASTSD GGVYWEGMDE VAEGVKITDW QGRPWKKGET
     KTPAAHPNSR FCSPAAQCPI IDGAWEDHEG VPISAILFGG RRPAGVPLVY EANSWAHGVF
     LGAAMRSEAT AAAEHKGKVI MHDPFAMRPF FAYNFGHYLD HWLSMESRSS RLPKIFHVNW
     FRKDNNGNFM WPGFGENSRV LDWIIRRIDN EPCFQDTAIG RIPSRGALNV EGLKQPIDLD
     TLFSIPKAFW TQEVEEIAKY FDNQVGKDLP EAIGRELSDL KKRINDIKE
//