ID   A0A1B0FAJ7_GLOMM        Unreviewed;      1391 AA.
AC   A0A1B0FAJ7;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   RecName: Full=Arf-GAP domain-containing protein {ECO:0000259|PROSITE:PS50115};
OS   Glossina morsitans morsitans (Savannah tsetse fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC   Glossinidae; Glossina.
OX   NCBI_TaxID=37546 {ECO:0000313|EnsemblMetazoa:GMOY000533-PA, ECO:0000313|Proteomes:UP000092444};
RN   [1] {ECO:0000313|Proteomes:UP000092444}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Yale {ECO:0000313|Proteomes:UP000092444};
RA   Lawson D.;
RT   "Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African
RT   Trypanosomiasis.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000092444}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Yale {ECO:0000313|Proteomes:UP000092444};
RG   International Glossina Genome Initiative W.H.O.;
RA   Lawson D.;
RT   "Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African
RT   Trypanosomiasis.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EnsemblMetazoa:GMOY000533-PA}
RP   IDENTIFICATION.
RC   STRAIN=Yale {ECO:0000313|EnsemblMetazoa:GMOY000533-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the 5'-nucleotidase family.
CC       {ECO:0000256|ARBA:ARBA00006654}.
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DR   EMBL; CCAG010018439; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 37546.A0A1B0FAJ7; -.
DR   EnsemblMetazoa; GMOY000533-RA; GMOY000533-PA; GMOY000533.
DR   VEuPathDB; VectorBase:GMOY000533; -.
DR   Proteomes; UP000092444; Unassembled WGS sequence.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0007420; P:brain development; IEA:InterPro.
DR   GO; GO:0009166; P:nucleotide catabolic process; IEA:InterPro.
DR   GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR   CDD; cd08833; ArfGap_GIT; 1.
DR   CDD; cd07406; MPP_CG11883_N; 1.
DR   Gene3D; 3.60.21.10; -; 1.
DR   Gene3D; 3.90.780.10; 5'-Nucleotidase, C-terminal domain; 1.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR   Gene3D; 1.20.120.330; Nucleotidyltransferases domain 2; 1.
DR   InterPro; IPR008334; 5'-Nucleotdase_C.
DR   InterPro; IPR036907; 5'-Nucleotdase_C_sf.
DR   InterPro; IPR006179; 5_nucleotidase/apyrase.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR037278; ARFGAP/RecO.
DR   InterPro; IPR001164; ArfGAP_dom.
DR   InterPro; IPR038508; ArfGAP_dom_sf.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR041821; CG11883_N.
DR   InterPro; IPR047161; GIT-like.
DR   InterPro; IPR022018; GIT1_C.
DR   InterPro; IPR013724; GIT_SHD.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   PANTHER; PTHR46097:SF3; ARF GTPASE-ACTIVATING PROTEIN GIT; 1.
DR   PANTHER; PTHR46097; G PROTEIN-COUPLED RECEPTOR KINASE INTERACTING ARFGAP; 1.
DR   Pfam; PF02872; 5_nucleotid_C; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF01412; ArfGap; 1.
DR   Pfam; PF12205; GIT1_C; 1.
DR   Pfam; PF08518; GIT_SHD; 2.
DR   Pfam; PF00149; Metallophos; 1.
DR   PRINTS; PR01607; APYRASEFAMLY.
DR   SMART; SM00248; ANK; 3.
DR   SMART; SM00105; ArfGap; 1.
DR   SMART; SM00555; GIT; 2.
DR   SUPFAM; SSF55816; 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain; 1.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR   SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
DR   PROSITE; PS50115; ARFGAP; 1.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT   DOMAIN          674..823
FT                   /note="Arf-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50115"
FT   REPEAT          869..901
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REGION          85..122
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1119..1174
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        85..117
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1391 AA;  155174 MW;  8CB1C3367D35CC98 CRC64;
     MAGITTSHTG MRTKLVDIIE NSPATAHESI EVTKGLRNVV GWLKQASIEV REAGKRAVTQ
     IQNSDPNFLS HEFDLNEQAT LVSFEDQSEL KSNNKSSSQQ DLGRRHHSLS QPQSPRARGR
     GRDNFIADYN RSASVISQLE KSKILMKMES YNKPLTILHY NDVYNVDATS QVEPIGGAAR
     FCTAMKTFKD ENPLVLFSGD IFSPSMLSTF TQGEQMIPVL KALGTHCAVF GNHDFDHGLD
     VLVDLIKQTS FPWLMSNVVD NETGRPLGGG KISHFIFHNH LSIGLIGLVE KEWLETLPTI
     DPKEVTFIDY VDAGIKLAAE LRNEGCEIII ALTHMRTPND INLAENCPDI DLILGGHDHV
     YEIKEVNGVK IIKSGTDFRQ FSKITLLPKR NDKGKIAVDV EAVDVTSEFP EDTELKDELA
     KYSDLIEVKM TEILGTFTVE LDGRFAAVRT QETNLGDWVC DVVLAATGAD VVIINSGTFR
     SDQIHPAGPF TMRDLVNIIP MRDPLVLIEI TGRCLHESLE NAVSGYPKLE GRFPQVSGVT
     FAFDPSKPAG HRVDPQLIQV GDEYLSMEQT YKACIKSYLY NGCDGFTMFK EAKVLMDDDS
     CPELGLTVQN HFKAINMRTG KGGHHTKHRQ SLVALSRRHS MVQMLDNLEL DGPSPIRKLS
     VGHQQVKSTD IANTSNNRML RRASLDDLEQ ASCQLAPKIQ HRIIRILNQE VNPSWASINR
     GILLCSDCCS IHRSLGRHIS IVKSLRHGIW EPSVLNFVNS LNAHGANSVW EHHLLDGTNS
     SNIKGSSRLR KPSPKDALHP NKSDFIKAKH VQLAFVLKPN LQDDDDVSGS CLEKELSKQL
     HASVRTSNLE ISLRLLAQGA DPNFFHEEKR STPLHVAAKF GQVSQIELLI IYGSDINVID
     GNGLTALEVA KTNNHTLVAE RLLEVMYEVT DRIIMFLGGK KPDHASGRHL HIPEVNSGDI
     SDQLKVARGR LQLVPNKIFE ELVMDLYDEV DRRENEAIWA CSVFSAENIV PFLPANPFLS
     ATRNQGRQKL ARFSRTEFNG LLTDVLIDAR RRQNMANLRP LDMPTTAPSA STLQNSNLSF
     YNNTNANVAD PNLSDDEPIY DPVADDDYEA MPAIAQQTIA HQSAAQEETN LEMENLRKQI
     NDYVSEINQL KTVVQKLSNE NSELKSKFSN VTQRTLNASN SSIYDEPLRI DFTPNDQEQE
     LRSLPEGLTT NPLMVNISNC SSSTTSSATN SNQSTIKRPA SMYERRLTAT FTKAQNESRN
     TTSMYQMAGD KVLREELNQK ADMVTHRLKE LIHSMQDPSN HGSLVPCAEH IRTSVLELIK
     VFAVPSNCNE TIRETLMQLN RNNILIQHSC ENLRSALDTD DTAAIDKYTK DVRECAYYIA
     SATKTLVLQL D
//