ID A0A1B0FE21_GLOMM Unreviewed; 2207 AA.
AC A0A1B0FE21;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 13-SEP-2023, entry version 27.
DE RecName: Full=Rapamycin-insensitive companion of mTOR {ECO:0008006|Google:ProtNLM};
OS Glossina morsitans morsitans (Savannah tsetse fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC Glossinidae; Glossina.
OX NCBI_TaxID=37546 {ECO:0000313|EnsemblMetazoa:GMOY001849-PA, ECO:0000313|Proteomes:UP000092444};
RN [1] {ECO:0000313|Proteomes:UP000092444}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Yale {ECO:0000313|Proteomes:UP000092444};
RA Lawson D.;
RT "Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African
RT Trypanosomiasis.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000092444}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Yale {ECO:0000313|Proteomes:UP000092444};
RG International Glossina Genome Initiative W.H.O.;
RA Lawson D.;
RT "Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African
RT Trypanosomiasis.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:GMOY001849-PA}
RP IDENTIFICATION.
RC STRAIN=Yale {ECO:0000313|EnsemblMetazoa:GMOY001849-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RICTOR family.
CC {ECO:0000256|ARBA:ARBA00008878}.
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DR EMBL; CCAG010007395; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 37546.A0A1B0FE21; -.
DR EnsemblMetazoa; GMOY001849-RA; GMOY001849-PA; GMOY001849.
DR VEuPathDB; VectorBase:GMOY001849; -.
DR PhylomeDB; A0A1B0FE21; -.
DR Proteomes; UP000092444; Unassembled WGS sequence.
DR GO; GO:0031932; C:TORC2 complex; IEA:InterPro.
DR GO; GO:0031929; P:TOR signaling; IEA:InterPro.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR028268; Pianissimo_fam.
DR InterPro; IPR028267; Pianissimo_N.
DR InterPro; IPR029453; Rictor_IV.
DR InterPro; IPR029451; RICTOR_M.
DR InterPro; IPR029452; RICTOR_V.
DR PANTHER; PTHR13298; CYTOSOLIC REGULATOR PIANISSIMO; 1.
DR PANTHER; PTHR13298:SF11; RAPAMYCIN-INSENSITIVE COMPANION OF MTOR; 1.
DR Pfam; PF14663; RasGEF_N_2; 1.
DR Pfam; PF14666; RICTOR_M; 1.
DR Pfam; PF14664; RICTOR_N; 1.
DR Pfam; PF14668; RICTOR_V; 1.
DR SMART; SM01303; RasGEF_N_2; 1.
DR SMART; SM01307; RICTOR_M; 1.
DR SMART; SM01308; RICTOR_N; 1.
DR SMART; SM01310; RICTOR_V; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
FT DOMAIN 86..465
FT /note="Rapamycin-insensitive companion of mTOR N-terminal"
FT /evidence="ECO:0000259|SMART:SM01308"
FT DOMAIN 597..818
FT /note="Rapamycin-insensitive companion of mTOR middle"
FT /evidence="ECO:0000259|SMART:SM01307"
FT DOMAIN 997..1071
FT /note="Rapamycin-insensitive companion of mTOR"
FT /evidence="ECO:0000259|SMART:SM01310"
FT REGION 1165..1217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1741..1766
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1834..1853
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1942..1963
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1165..1190
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1199..1213
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1942..1957
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2207 AA; 243791 MW; C3E0EB91FA6DEC1D CRC64;
MKTVSLISQD PEDYYRLDPK KSAAENAYDI YTTLCCRETR DTKRLFLLNG LAALCQQQQK
QHRQPPPAQT STTVAATIIT TTTTTTTTAT TTTTVATASQ SVAKSNLGFT TEELLYCLSA
SLIHTFTQVR AAALRTIRYV LATTDDIKIF NSMQLPYLLC RSIDLMLKND DERVQALKLI
RKMLAISAID ISSVVVRCLV SLADTGIEEN DNLLRACLAT LCEFAVLNPS LLICCGGVTS
ITRNVLECHN PRIAESLSGV LLYLLEWPQT RNICGVRLDC LAAPYCDFTY RLGIMDKNKD
ARELRYTSCR LALLSVLRSW IGTIEFCDPS KQSGLKAIVD ALFLNQIEVR KAILELLYEL
LSLPQPTWTD DYSVALQAID PSDFQDNWLL NNGFVAAEGR SILPSLAARA PNVCEQQLAL
QLFCFLETGL LNALVEVIIA GEATVSVAAT ILIGKILHLM HTHLPPDICS TSPALPLLIS
HGARDNRYAS AAIATLQHYQ KMMRNRPASN SLFLDSIIQE GSLVHTRLFR REINAQDLSL
TLSQQSPSTV AGGLNTTVMS LERTHLDSVS SSEESNSQSS SARRSSFRLK CKFLPFLENI
KVNRLIKDSK VFQMPDSMGW DWEVISTILR SNLIRKMDDT IAKFLKALVE YFKPSNNLFS
HQELVPGRSL PTYVTVGLDL IDWLLASHSL ESMRLLTDFF SDVAQHLLAI TTSNRAHDCL
FSPQHVNNTM CQQYFLYIGR MCRVQKGISI LTNTAVFEHL VNLVRNTDHV CYVKLIVSGL
DYTMDSVTRK VLENALTSAK ARSGRLYATQ FLMVLLRARI PNFEEWGIPM IIQQTKDPDR
SVVLAAMEVL EEACHEKYYL EEIVSLWPNL KPLGDVGRLL MARYYSISRG LNQLKAKIKE
EIEYWRNGYN KRRAEYVLLV DADTHSSLTL HVRNEDGYYS RRNCNTRPVI VPPNIPPHLY
GQMVQTTQGT TALRKFGDLP QLIDTIDQAK CTDERECLEL KAAIWAIGHA STHSNGIEYF
LDTDQRIYEK LIILATNCEV YSIRATCFNA LGLISCTNAG ANVLFKLNWL SVRHDRNTIW
PVHQPEDWIA GNFTPVRHHC VDMPPYNYPG MQDQIDSSCY VGSNWNLLLS SSSTARDAMT
GEASASSEAQ DANTTTDSIK TSGEEMSFKQ GSAGASGSGT NTSGSIIPAS AKSKTLPEGS
YPRHAKHQRS LSESKTTDVI SLISGSGAAT GATGGMITSF STHYSYRTRY NSYTDSNTSG
VSSCESVTGR AVNVGEHQQF PLTPIPSMSN LQEIPLGRSS LMKRRIGPAD VKGYAQFRSL
RRHCRPLLSE SAAELYDIVD RIDLLSFASF RPRKSSFGDS QRKMKVRSLD RQTSLRMYAQ
FDLEELQVPL PTLNTPKFLS QNDSKGPCYA GISLPKNILD LFPRRNLSRT YVSQDIRDQD
LIDVNLLTAK QQFLNDSINN EAGDESSVIS SLSDVSSVSK RSKWTGAKHG RNNCLHCSRL
RRSYRPNSQR LVGDTSANAV ICELNANALV ALTTAGAHGT ESIPNKTESE ISVAAVCSGK
NASHPIQSTT VSSVQLFDVG YFQSPESILS EESLPDKLTA NILYNVQRLA NPVSAKQSKM
ALLELKQKHP ASFQDICLYS EVCKTLGRWS YRMNARRFLQ ELFLDLDFES FHNEPLEIIA
RKEKEFKKEE QRIVDLSVEG SSRHIVSCEV HKATGLNKNE TSLSELSSSV GACKTTAREV
LPGISSSNTN SSSSSSNFSN QPLKPHLKSQ PLASVYEASC ENLHSDPSPR LKTTASTTSA
KVLHLLPNCK NFTVAPPPAA PPPVHEFNKE LRITSDDDDD DTSENSGRLP FPNRSAKFEW
DEVDGLETNS SSTFNPTSDA HCQPELNSPS YTNYSIAQTT PLLHTTSGVI TTPIGSSNCS
DKTTTSNHSS ICTVSQHPIN SKLNSSTSFT SPPGNKPIEN ENKKYTRGRF YTLELDLSFA
KNKFPITHRT RTNIGIAKNS DKQLTHTSTN ANTNNTNNNN KLSNSLIITT AATCKNNSPL
KVTNPPTILR QGSFGTTINY HPLTSRQSYT AGITPITNEV IASSEASSNF PLTITKSLAA
SLAQPIGKLY CEKRLQSSKS EVILNQVPSV ITIASSSSSS VTTTTNNHTT SLTRITGNAI
SSGIGGGDVD SDNRNDVTDI HKINVTTTTT MTTTTPSSSI FDASKQS
//
