ID A0A1B0FGY4_GLOMM Unreviewed; 578 AA.
AC A0A1B0FGY4;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Kelch-like protein diablo {ECO:0000256|ARBA:ARBA00013699};
OS Glossina morsitans morsitans (Savannah tsetse fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC Glossinidae; Glossina.
OX NCBI_TaxID=37546 {ECO:0000313|EnsemblMetazoa:GMOY003012-PA, ECO:0000313|Proteomes:UP000092444};
RN [1] {ECO:0000313|Proteomes:UP000092444}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Yale {ECO:0000313|Proteomes:UP000092444};
RA Lawson D.;
RT "Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African
RT Trypanosomiasis.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000092444}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Yale {ECO:0000313|Proteomes:UP000092444};
RG International Glossina Genome Initiative W.H.O.;
RA Lawson D.;
RT "Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African
RT Trypanosomiasis.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:GMOY003012-PA}
RP IDENTIFICATION.
RC STRAIN=Yale {ECO:0000313|EnsemblMetazoa:GMOY003012-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- FUNCTION: Probable substrate-specific adapter of an E3 ubiquitin-
CC protein ligase complex which mediates the ubiquitination and subsequent
CC proteasomal degradation of target proteins. May have a role in synapse
CC differentiation and growth. {ECO:0000256|ARBA:ARBA00043912}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CCAG010007549; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A1B0FGY4; -.
DR STRING; 37546.A0A1B0FGY4; -.
DR EnsemblMetazoa; GMOY003012-RA; GMOY003012-PA; GMOY003012.
DR VEuPathDB; VectorBase:GMOY003012; -.
DR PhylomeDB; A0A1B0FGY4; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000092444; Unassembled WGS sequence.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd18186; BTB_POZ_ZBTB_KLHL-like; 1.
DR Gene3D; 1.25.40.420; -; 1.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 2.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR24412:SF35; ACTIN-BINDING PROTEIN IPP; 1.
DR PANTHER; PTHR24412; KELCH PROTEIN; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 3.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 5.
DR SUPFAM; SSF117281; Kelch motif; 2.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 49..116
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
SQ SEQUENCE 578 AA; 66707 MW; 066C1CBA2AD67BC4 CRC64;
MPQYYYLATR SVNRAHVCEA IDSEEPTVSS YSHVMLNSLN QLRLDQMHCD FILEAEGECI
YAHKLLLVAA SPYFGAMLQH NTKEKREGKV RFTDVEVSAL KAIVDYVYTG AITITEDSVT
SLLSTSNLLL IDAVKYNCEQ FLKRRVNLTN CLNIRKIADL YYCVELLLYC NKCIAKWFPR
LITVEEFLEL SFEEFKAIIK DDDLYVQKEE YAYQSVLNWV KYNLEARQVY LPELLRHINL
LLLRPEFLKS LIRTEPLFKH DLLCKDVFIE ALFHFLPGQK RKRSLDVSED TRRSQRRYGT
PHVAFVGGAN GDWQSLSTCR MYDISTARLF AMAPLAECRS GVSTVSLHEC LYATGGHNAQ
ITMKTAERYD PIINQWHHIA PMKNGHAFHG ACAFKNQIYV IGGDRSSSFE YYNPTTNKWY
DGPDTPSRYW WENRATVIGN SIYSLGDAEN GIILNNRYDP REGLWHILDN TTYYVRQFGL
AAYGHSLYCV GGWPWPNQCK RFDIRANRWE SLAAMNVGRD RHATLIIENE IYVFGGWNQI
LVPTAERYNI AQNKWTTDRS IAIELFVGGA AIIRHRTI
//
