ID A0A1B0FH40_GLOMM Unreviewed; 871 AA.
AC A0A1B0FH40;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Protein kinase domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Glossina morsitans morsitans (Savannah tsetse fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC Glossinidae; Glossina.
OX NCBI_TaxID=37546 {ECO:0000313|EnsemblMetazoa:GMOY003071-PA, ECO:0000313|Proteomes:UP000092444};
RN [1] {ECO:0000313|Proteomes:UP000092444}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Yale {ECO:0000313|Proteomes:UP000092444};
RA Lawson D.;
RT "Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African
RT Trypanosomiasis.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000092444}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Yale {ECO:0000313|Proteomes:UP000092444};
RG International Glossina Genome Initiative W.H.O.;
RA Lawson D.;
RT "Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African
RT Trypanosomiasis.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:GMOY003071-PA}
RP IDENTIFICATION.
RC STRAIN=Yale {ECO:0000313|EnsemblMetazoa:GMOY003071-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; CCAG010009633; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A1B0FH40; -.
DR STRING; 37546.A0A1B0FH40; -.
DR EnsemblMetazoa; GMOY003071-RA; GMOY003071-PA; GMOY003071.
DR VEuPathDB; VectorBase:GMOY003071; -.
DR PhylomeDB; A0A1B0FH40; -.
DR Proteomes; UP000092444; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR CDD; cd12219; Ubl_TBK1_like; 1.
DR Gene3D; 1.20.1270.420; -; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR003377; Cornichon.
DR InterPro; IPR033466; Cornichon_conserved.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR041309; TBK1_CCD1.
DR InterPro; IPR041087; TBK1_ULD.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR22969:SF15; FI05319P; 1.
DR PANTHER; PTHR22969; IKB KINASE; 1.
DR Pfam; PF03311; Cornichon; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF18394; TBK1_CCD1; 1.
DR Pfam; PF18396; TBK1_ULD; 1.
DR SMART; SM01398; Cornichon; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS01340; CORNICHON; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777}; Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 56..87
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 143..448
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 444..505
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000259|PROSITE:PS50053"
FT COILED 778..805
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 172
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 871 AA; 100189 MW; C2B3636367E3A94A CRC64;
MAFNFTAFSY IVALIGDAFL IFFAIFHVIA FDELKTDYKN PIDQCNSLNP LVLPEYLLHI
FLNILFLACG EWFSLCINIP LIAYHIWRYK NRPVMTGPGL YDPTTVLASD NLTKNIREGW
IKLAIYLISF FYYIYGGSLN YVWCTTSVLG KGATGSVFQG VNKITGESVA VKTFNPYSHM
RPPDVQMREF EALKKVNHEN IVKLLAIEED QEGRGKVIVM ELCTGGSLFN ILDDPENSYG
LPEKEFLLVL EHLCAGMKHL RDNKLVHRDL KPGNIMKFIS EDGHTIYKLT DFGAARELED
NQPFASLYGT EEYLHPDLYE RAVLRKSINR SFTANVDLWS IGVTLYHVAT GNLPFRPYGG
RKNRETMHQI TTKKASGVIS GTQLSENGPI EWSTTLPAHC HLSEGLKTLV TPLLAGLLEE
NREKTWSFDR FFQEVTNILR KRVIHVFYTN RTSSVEIFLE PEELIEHFRE RVLMQTKVPM
ERQILLFNNE HLEKKVTPHT IGEYNNNNLK RLIIPFVAKA FPATYTENPI FLYSNDDNNV
QLPQQLDLPK FPVFPNNVSV ENDASLAKAA CSVGHECKRR VDTFTTIDIL IKKAVAQFIE
TLTTTITLLI KKTKNFDKLI TTVIEYVDAV KCMSKMTKGE EELNPLLYKL EKLRTEFEGA
ADVIMQLHTN FVMGDQLNDQ WSSAMHGKHC PCRTRASAQA KYLIERLRDS WQHLLRDRAT
RTLTYNDEQF HALEKIKVDR NGKRIKSLLL DDVKPSVAQM AECLADWYKL AQTVYLKSEI
LEKDVREYER NLDILKEDLY KIKTDIQKDM DAKLFNNSNQ LLKIEQKNRL RFMQQQQEEI
MALMKENRQF IGMLQELGTN LGSSLTGTLK I
//
