ID   A0A1B0FI39_GLOMM        Unreviewed;       983 AA.
AC   A0A1B0FI39;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=Vacuolar protein sorting-associated protein 18 homolog {ECO:0000256|ARBA:ARBA00017338};
OS   Glossina morsitans morsitans (Savannah tsetse fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC   Glossinidae; Glossina.
OX   NCBI_TaxID=37546 {ECO:0000313|EnsemblMetazoa:GMOY003458-PA, ECO:0000313|Proteomes:UP000092444};
RN   [1] {ECO:0000313|Proteomes:UP000092444}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Yale {ECO:0000313|Proteomes:UP000092444};
RA   Lawson D.;
RT   "Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African
RT   Trypanosomiasis.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000092444}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Yale {ECO:0000313|Proteomes:UP000092444};
RG   International Glossina Genome Initiative W.H.O.;
RA   Lawson D.;
RT   "Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African
RT   Trypanosomiasis.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EnsemblMetazoa:GMOY003458-PA}
RP   IDENTIFICATION.
RC   STRAIN=Yale {ECO:0000313|EnsemblMetazoa:GMOY003458-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Late endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004492}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004492}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004492}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004287}.
CC   -!- SIMILARITY: Belongs to the VPS18 family.
CC       {ECO:0000256|ARBA:ARBA00010454}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CCAG010009519; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A1B0FI39; -.
DR   STRING; 37546.A0A1B0FI39; -.
DR   EnsemblMetazoa; GMOY003458-RA; GMOY003458-PA; GMOY003458.
DR   VEuPathDB; VectorBase:GMOY003458; -.
DR   PhylomeDB; A0A1B0FI39; -.
DR   Proteomes; UP000092444; Unassembled WGS sequence.
DR   GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR   InterPro; IPR007810; Pep3_Vps18.
DR   PANTHER; PTHR23323; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN; 1.
DR   PANTHER; PTHR23323:SF26; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG; 1.
DR   Pfam; PF05131; Pep3_Vps18; 1.
DR   PROSITE; PS50236; CHCR; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          45..459
FT                   /note="Pep3/Vps18/deep orange beta-propeller"
FT                   /evidence="ECO:0000259|Pfam:PF05131"
FT   COILED          828..862
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          907..955
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   983 AA;  113211 MW;  F1B23145EF49BD06 CRC64;
     MAAYSDSAAN EKPHITVVRP KFLQTVEKSN NSDASSSNND DSETPIFSKR KILLRIPKQY
     KGDFMHLTVS KNWLVCLLAA PPPATQITLL RFFLLRALPP GEIALEKYLA GYKIGNLFLD
     YTGHHMLISL IPKSPGLLAD FLYIHGNGPK VRRIEKFKDH EITSVAFNRE YGTESSTGPI
     LLGTNRGLIF ETELTLEAEK PSYKKQVYDL GLGRPKYPIN GLEFLRVPNT NQYLIIVAAP
     DYIFTFQETL RSDEKSLQAI FTGYVNGTQS HGFETAKTDL NYSVLKLYAQ PGEKFASLWG
     WLCGSGIRHG RIAQSSITTE KFLLGDDLVP LDKDIEQRKH LSSEERRLSV PVSFVLTEYH
     VLLMYPDHIT GICLLNQQVI YEEYFHEQMG KLLNIVRDPF TGSVYVYTEK MLFNYKICDE
     HRHVWQIYLG KGLYDLAEAH AGNAKNKNLV LESKAEAAIQ TGNYKAAAEI LADTNNAFEE
     VCLKFIDLQD KRPIITYLRK RLDKLPTENN EEQLMVLVTW LVDLYLTEIN YPGRSKVEKE
     EWQMAYDEFM RQFSVVKFVR ANRATIHKLI AQHADNHNLA QFAIANEDYE EVVLQHLAAE
     KYLDALNILR KQKDPELYYK YCPIIMEFIP HETIEVLKSQ GRKFQVTKLI PTLITIDTPL
     HIAEVTKYLE YCIYNLCETN TSVHNYLVRL YAQHQPPKVI EYLETEGHDA SLVHYDINYA
     LCVCLQFKVH EACVFLYCLL ELWYDALDVA LGFDMALAKA TASKPKDEET KSELWLRIVC
     HEIEGTNDVK KALDLLNECD LLRIEDLLPF FSDFEKIDDF KEPICKALKV YNQKIQELQH
     DMEECTKQSE RVQNDLENIR ERCLIIEGQE ICNSCDTYLL VKPFFVFGCG HKFHADCLEK
     SVVPLLISEQ SRKLTMLKQQ LESMLTQSAA MAENSKELQK KREKLKHEIE RIVAGDCPYC
     GLMIDTIDQP FVEDWDQVNV DWE
//