ID A0A1B0FNZ8_GLOMM Unreviewed; 1222 AA.
AC A0A1B0FNZ8;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=FCS-type domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Glossina morsitans morsitans (Savannah tsetse fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC Glossinidae; Glossina.
OX NCBI_TaxID=37546 {ECO:0000313|EnsemblMetazoa:GMOY005621-PA, ECO:0000313|Proteomes:UP000092444};
RN [1] {ECO:0000313|Proteomes:UP000092444}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Yale {ECO:0000313|Proteomes:UP000092444};
RA Lawson D.;
RT "Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African
RT Trypanosomiasis.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000092444}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Yale {ECO:0000313|Proteomes:UP000092444};
RG International Glossina Genome Initiative W.H.O.;
RA Lawson D.;
RT "Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African
RT Trypanosomiasis.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:GMOY005621-PA}
RP IDENTIFICATION.
RC STRAIN=Yale {ECO:0000313|EnsemblMetazoa:GMOY005621-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; CCAG010013125; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A1B0FNZ8; -.
DR STRING; 37546.A0A1B0FNZ8; -.
DR EnsemblMetazoa; GMOY005621-RA; GMOY005621-PA; GMOY005621.
DR VEuPathDB; VectorBase:GMOY005621; -.
DR PhylomeDB; A0A1B0FNZ8; -.
DR Proteomes; UP000092444; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0032991; C:protein-containing complex; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0031507; P:heterochromatin formation; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd20119; MBT_dSfmbt_rpt1; 1.
DR CDD; cd20122; MBT_dSfmbt_rpt2; 1.
DR CDD; cd09580; SAM_Scm-like-4MBT; 1.
DR Gene3D; 2.30.30.140; -; 4.
DR Gene3D; 3.30.60.160; -; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR004092; Mbt.
DR InterPro; IPR047358; MBT_dSfmbt_rpt1.
DR InterPro; IPR047359; MBT_dSfmbt_rpt2.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR037605; Sfmbt_SAM.
DR InterPro; IPR012313; Znf_FCS.
DR InterPro; IPR038603; Znf_FCS_sf.
DR PANTHER; PTHR12247; POLYCOMB GROUP PROTEIN; 1.
DR PANTHER; PTHR12247:SF104; POLYCOMB PROTEIN SFMBT; 1.
DR Pfam; PF02820; MBT; 4.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF21319; zf-FCS_1; 1.
DR SMART; SM00561; MBT; 4.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 4.
DR PROSITE; PS51079; MBT; 4.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS51024; ZF_FCS; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00367}.
FT DOMAIN 311..346
FT /note="FCS-type"
FT /evidence="ECO:0000259|PROSITE:PS51024"
FT REPEAT 519..630
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 638..736
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 749..824
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 832..928
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT DOMAIN 1144..1207
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 258..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 929..958
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1056..1108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 356..387
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 258..278
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1222 AA; 135431 MW; 710921EE9F9FEE9F CRC64;
MYKMNPSELT MMWMNQYNPD RISLEEATSF FHPSSVDMTH QQTVDLNPVM SIVGGDFSGH
AAAAAAAVAA SSAAAAAALG VQPTTLLAAN TNDIYGLAQM GGLHQQLLQQ SAATVFQNYT
AIEDDDGSSA VTGINNTLND ANNRIQTQFI TNHNLHQQQQ QQQQQLVYDQ MDNDAYEDGV
ANLTPKQEII NIDDFVMMTD SNSYDGAEFV HPAKSSGIDI TQPNSIDEHD LLEPLSQEHK
LLSEAAAAAN RNLLMTAQTA SASPSSAGGG SGNNSLRAQR KTRKIEPVNR PGLVLKTPIA
YKGNIDPSVI PIQKDGMAVC ERCGAIGVKH TFYTKSRRFC SMACARGELY SLVVNNKSTN
QQHQHQRENM ESLLNDQQLQ SEQQQKQQSS DIELALRVAH IKNANYRFRI TDQSKLTQVN
GYDESVNNNT ESSENVAEVN SGSSLANNGL ESAITDDGSG LQLSANNQQP PKTVRMCRDV
MPQEELPQIP KLERLPTPCP QLEKIISIRR RLYDPTHSFD WTQRLASKDF FAAPVTCFPH
APGYDVWDNL GIDMKVEVEN TDCDQMEVIQ PGQTPHSFWV ATILNIYGYK ALMRYEGFDD
DSHDFWVNLC NAEVHSVGWC ATRGKPLIPP RTIENKYKDW KEFLVSRLSG ARTLPSSFYN
KVNDSMQSRF RLGLNLECVD KDRISQVRLA TVTKIVGKRL FLRYFDSDDG FWCHEDSPII
HPVGWATTVG HNLAAPQDYL ERMLDGKTNG FMEGMKLEAV DPLNLSSICA ATVMAVLKFG
YMMIRIDSYQ PDATGSDWFC YHEKSPNIFP VGFCASNSIP LTPPNGYDIN TFSWEIYLQE
TGSVPAGEHL FHREVPNHGF EMGMSLECAD LMDPRLVCVA TVARVVGRLL KIHFDGWTEE
YDQWLDCESA DIYPVGWCVL VNHKLEGPPM PTQAVAKTPS KPKTQKRRKK KSNSNVTATT
ALSTQGKLNI EQAAQAKSRT IALKTNPHLP KLSIKLELKP EHQNPAFYED NSIGVNDDDD
DVADNYEEDS NSVQSNQSST AHLIDTSSSS TSFIATHSGT TTSSSSTTLL VNPAAVNSEK
VRKSNNRTSV KKSQSPAPPT VRRKANSYIA NSSVSNSKYI PRVSDGGDTS ASADHIGELM
PDSWNVYDVS QFLRVNDCTA HCDTFSRNKI DGKRLLQLSK DEVITLLGMK VGPALKIYDL
IQQLKCKANP SKSRMHKANK FL
//
