ID A0A1B0FQI0_GLOMM Unreviewed; 1090 AA.
AC A0A1B0FQI0;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=G-protein coupled receptors family 1 profile domain-containing protein {ECO:0000259|PROSITE:PS50262};
OS Glossina morsitans morsitans (Savannah tsetse fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC Glossinidae; Glossina.
OX NCBI_TaxID=37546 {ECO:0000313|EnsemblMetazoa:GMOY006177-PA, ECO:0000313|Proteomes:UP000092444};
RN [1] {ECO:0000313|Proteomes:UP000092444}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Yale {ECO:0000313|Proteomes:UP000092444};
RA Lawson D.;
RT "Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African
RT Trypanosomiasis.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000092444}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Yale {ECO:0000313|Proteomes:UP000092444};
RG International Glossina Genome Initiative W.H.O.;
RA Lawson D.;
RT "Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African
RT Trypanosomiasis.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:GMOY006177-PA}
RP IDENTIFICATION.
RC STRAIN=Yale {ECO:0000313|EnsemblMetazoa:GMOY006177-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|ARBA:ARBA00010663, ECO:0000256|RuleBase:RU000688}.
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DR EMBL; CCAG010022087; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A1B0FQI0; -.
DR STRING; 37546.A0A1B0FQI0; -.
DR EnsemblMetazoa; GMOY006177-RA; GMOY006177-PA; GMOY006177.
DR VEuPathDB; VectorBase:GMOY006177; -.
DR PhylomeDB; A0A1B0FQI0; -.
DR Proteomes; UP000092444; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 4.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24248; ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR24248:SF72; DOPAMINE_ECDYSTEROID RECEPTOR, ISOFORM A; 1.
DR Pfam; PF00001; 7tm_1; 3.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 3.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|RuleBase:RU000688};
KW Transducer {ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 58..83
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 95..116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 137..159
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 401..422
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 655..676
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 688..710
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 964..985
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 997..1019
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 37..707
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT DOMAIN 937..1016
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT REGION 190..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 271..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 346..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 759..822
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 853..876
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1066..1090
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..288
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 289..303
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 766..788
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 795..822
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 856..873
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1075..1090
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1090 AA; 121631 MW; 18F15FBAA892E143 CRC64;
MNETECEDLI KSVKWTEPSN LISLAILEFI NVLVIGGNLL VIAAVFCSNK LRSVTNFFIV
NLAVADLLVG LAVLPFSATW EVFKVWIFGD VWCRIWLAVD VWMCTASILN LCAISLDRYV
AVTRPVTYPS IMSTKRAKSL IAGIWVLSFV ICFPPLVGWK DEKPLAQPIT YTRGNYTLYY
ATSSTKATTT TTTTASTTSR TSPITSPSLS LTSPSLSSFA DWSAKTAEQK LKLRQQNTYA
ASTAHNLPPT PVKASVYNDF SPYDPYHAHL SNNKNTSTSN NAMNNYDNNN NDDDDDDGIS
DDVDASVGIE DVYALTPDAQ ENILYNNRPS LSSSTLLYDD SGMDDTTLVS SSKSKLKETQ
RETDRETATA TAPVTATATA TTTTLALPCP WKCELTNDRG YVLYSALGSF YIPMFVMLFF
YWRIYRAAVR TTRAINQGFK TTKGGHESHT NRPDETQLVL RIHRGRPCTT TQRTPLSMHS
MSSMLSVNSN GDDTLYGLQH SQLQQQSSSN LILPKRATSM RLTKQKHEKV AVKVSFPSSE
NMMEAGNERT MTAPTFKALT VHEGVAASST MQKALSLTNG QRGSFKSSLC DIGETTFNNE
AFTSTDTSTM ALNHQRDDVE IVRDSSQKQD KKQRGKRSVR FQVKRFKVET KAAKTLAIIV
GGFIFCWLPF FTMYLIRAFC DHCIPATLFS VLFWLGYCNS AINPVIYALF SHEFRIAFKR
IVCRCVCTRS GFRASENFQM IAARALMAPA TFHKTISGCS DDGEGDGDGD GSKGVGTRFD
EQRLTLRIHR GRGSTALDST HSNGSTYSTS TTTGTPSPER LSKYSTRRYH PNHDKIKISV
SYPSSDNIAA MNTTSHDHHE QSKTQRHERE QRTPSTCSGN MLYAVHYSST NGRNMTESQL
YSSHQSSNYY LQVGKAMPDM LRRPSVVNDQ SSQLGNIRNN KKMGKRNIKA QVKRFRMETK
AAKTLAIIVG LFIFCWLPFF TMYIIRSFCE DCIDPLLFSV IFWLGYCNSA VNPMIYALFS
KDFRFAFKRI ICRCFCLRKS LNLKSSRRGS DLSAIRIGGI RTPSITPSAA AHSLDDESEL
QHSELSSDPR
//
