ID A0A1B0FQP9_GLOMM Unreviewed; 1831 AA.
AC A0A1B0FQP9;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 22-FEB-2023, entry version 28.
DE RecName: Full=chitin synthase {ECO:0000256|ARBA:ARBA00012543};
DE EC=2.4.1.16 {ECO:0000256|ARBA:ARBA00012543};
OS Glossina morsitans morsitans (Savannah tsetse fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC Glossinidae; Glossina.
OX NCBI_TaxID=37546 {ECO:0000313|EnsemblMetazoa:GMOY006296-PA, ECO:0000313|Proteomes:UP000092444};
RN [1] {ECO:0000313|Proteomes:UP000092444}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Yale {ECO:0000313|Proteomes:UP000092444};
RA Lawson D.;
RT "Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African
RT Trypanosomiasis.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000092444}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Yale {ECO:0000313|Proteomes:UP000092444};
RG International Glossina Genome Initiative W.H.O.;
RA Lawson D.;
RT "Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African
RT Trypanosomiasis.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:GMOY006296-PA}
RP IDENTIFICATION.
RC STRAIN=Yale {ECO:0000313|EnsemblMetazoa:GMOY006296-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-
CC D-glucosamine = [(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + H(+) +
CC UDP; Xref=Rhea:RHEA:16637, Rhea:RHEA-COMP:9593, Rhea:RHEA-COMP:9595,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17029, ChEBI:CHEBI:57705,
CC ChEBI:CHEBI:58223; EC=2.4.1.16;
CC Evidence={ECO:0000256|ARBA:ARBA00000319};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CCAG010001599; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 37546.A0A1B0FQP9; -.
DR EnsemblMetazoa; GMOY006296-RA; GMOY006296-PA; GMOY006296.
DR VEuPathDB; VectorBase:GMOY006296; -.
DR PhylomeDB; A0A1B0FQP9; -.
DR Proteomes; UP000092444; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004100; F:chitin synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd04190; Chitin_synth_C; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR InterPro; IPR004835; Chitin_synth.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR PANTHER; PTHR22914; CHITIN SYNTHASE; 1.
DR PANTHER; PTHR22914:SF14; CHITIN SYNTHASE; 1.
DR Pfam; PF03142; Chitin_synth_2; 1.
DR Pfam; PF00083; Sugar_tr; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 38..60
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 184..202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 214..233
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 240..261
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..296
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 352..376
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 388..408
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 483..509
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 540..561
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 573..599
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 605..625
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 634..654
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 660..678
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 705..723
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 803..821
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 833..856
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1343..1370
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1376..1398
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1405..1430
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1436..1455
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1467..1486
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1579..1598
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1638..1659
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1704..1733
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1831 AA; 210262 MW; 35F872EDC82B8E1B CRC64;
MIDNELNEES EVRAKETANE STLDAILVRI GEFGRFQLFN YVLLCLPMIF NAFQSISYVF
TASSVVYRCN VTLCDSARSE YWEQWLSFTI PSTNSNFDQC HHYAIINSSD MQLKCSAENF
NSSQLENCYD YKFRDHEYTI ANEFNFFCSN EWKLTMAGTF NNIGQFIGIP LGGLLADKFG
RRTMLAIGGF LSSIMGLIKS FATNYSMFLT FETFDMIVGS TLYPTAFLLA IELVGPKRRV
AAATIITMFY PLGEALLGVF AKQFQNWRIL LRVLYAPAIL HIFLLILLPE SVRWLLSQGK
ERKAVAVLGE AAHVNGKFIP ELNFINLMES NKQKLEDNAE EIYPIKDAIK VFFWRIANCS
LCWFTHTLIA LGLSLTSVNL GDGEGVELTL FLIGKFAITC SFQILYFFTS EIFPTKVRNS
LLSLCSMIGR FGSMLAPQTP LLVNKNKERP PLWDSFQDPP SKRATGSAAN WSKLGVVLKV
FKILTYLLVF VVMLGTAVIS KVSFIFMAAQ ISFKDNVTYC QTIEPNENFE ANLPAVERIA
WIWALIFSFA APEVFTFFRS LRICVFKDVK SPTWLEVVLV ISFELLHVAG LSVLIFYVYP
RIDSIRAVFL CNGVCFIPSV LNILMGTRIR GKSIAVYSIS LLALIAQAST FVVWPAINDS
MAMQILVVPL ILISFRWWEN YINSYSSIVN LIKLVRRTKS RYHTYLYLSP VKILLFTLTA
FALTGQPMED YFTKFTQAWK PHDIVIKKIS LGIIDSHNLS QPPSLSTFSS GLILPSAHLL
TTELSTIQYN HHQQFIVQSN PNAVVSLLLS QVLSSYLCYI FGKFACKIKI QEFSFALPIS
LATPLSAATI VILIWLRETD VCSFNDYLPN YLSFRVPVLD DDNDDYAGKP LQWRRLGNAF
TKDYVWLWIL WWLSQLWITK HIWSPKNDKN LPTEKLFICP WYSGFFIEQC ITMNRRIADW
NEDYLSIKSE SPSPNGNGTT DILETDKIPQ LIVCATMWHE TQDEMMEFLK SIVRLDEDQC
ARRMAKIYIN SGKADDEYYE LETNIFFDDA FVLDEKCMEN PKNPPLNEYV KLLITSIEKA
AFEVYGVQIK IKSPVKIETP YGGRLVWTLP GRSKMIAHLK NKDKIRHKKR WSQVMYMYYL
LGFRIMELEN VSAKRKAVIA ENTFLLALDG DIDFQPQAVQ LLIDRMKAID ELGAACGRIH
PVGRGPMVWY QIFEYAIGHW LQKATEHVIG CVLCSPGCFS LFRGSALMEN SVMKKYTTVS
QEPMHYVQYD QGEDRWLCTL ILKQGLRVEY SAASDAYTHS PEMFNEFYNQ RRRWVPSTIA
NIFDLLSDAD LVIKNNSSIS MPYIVYQAML MVGTVLGPGT IFLMMVGALV TVFSTGIWNA
FLWNFIPLLT FILSCIYLKQ KYQLLLAFVI SSLYCLVMMA VLIGIIIQII DDGPLAPASL
FFLLVFLQIF IAGLVHPQEV AALICGFIYY ITIPSMYMLL LIYSVFNMND VSWGTREVAP
KKEDESSAPS QQLDENNKEK DYLPGWINDP LLVDSELGEI SLREKRFWKE LIKLYLRPLF
HTKEKKLEIA DSLRELRNMF AFAFVMINSI FVLVVFLLQL KKDYLHLEWP IDPIDFITYD
DINSQIYIYR RYKELDPIGL CFVVFFGLIL IIQFIAMFFH RFATISQLLA TTKLDWFRTS
SALTEEDAAQ EIRGNAVHIA HQLQRPKRLD DDDDEDDDDA VSDFGRANDD SNDGAVRMAR
RQTIFKLHES RNKNQYDYSD LPRNFERRFF GDDDINVKHI SMSRKSLMML NKTRFVTKRR
LTEQVRCNTD FNRCPPQECY DNIAFDDSTK V
//
