ID A0A1B0FRL6_GLOMM Unreviewed; 174 AA.
AC A0A1B0FRL6;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 22-FEB-2023, entry version 25.
DE RecName: Full=Transmembrane protein 208 {ECO:0000256|ARBA:ARBA00015033};
OS Glossina morsitans morsitans (Savannah tsetse fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC Glossinidae; Glossina.
OX NCBI_TaxID=37546 {ECO:0000313|EnsemblMetazoa:GMOY006598-PA, ECO:0000313|Proteomes:UP000092444};
RN [1] {ECO:0000313|Proteomes:UP000092444}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Yale {ECO:0000313|Proteomes:UP000092444};
RA Lawson D.;
RT "Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African
RT Trypanosomiasis.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000092444}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Yale {ECO:0000313|Proteomes:UP000092444};
RG International Glossina Genome Initiative W.H.O.;
RA Lawson D.;
RT "Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African
RT Trypanosomiasis.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:GMOY006598-PA}
RP IDENTIFICATION.
RC STRAIN=Yale {ECO:0000313|EnsemblMetazoa:GMOY006598-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- FUNCTION: May function as a negative regulator of endoplasmic
CC reticulum-stress induced autophagy. {ECO:0000256|ARBA:ARBA00003220}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMEM208 family.
CC {ECO:0000256|ARBA:ARBA00009950}.
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DR EMBL; CCAG010007092; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A1B0FRL6; -.
DR STRING; 37546.A0A1B0FRL6; -.
DR EnsemblMetazoa; GMOY006598-RA; GMOY006598-PA; GMOY006598.
DR VEuPathDB; VectorBase:GMOY006598; -.
DR PhylomeDB; A0A1B0FRL6; -.
DR Proteomes; UP000092444; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR008506; SND2/TMEM208.
DR PANTHER; PTHR13505; TRANSMEMBRANE PROTEIN 208; 1.
DR PANTHER; PTHR13505:SF7; TRANSMEMBRANE PROTEIN 208; 1.
DR Pfam; PF05620; TMEM208_SND2; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 27..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 54..71
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 105..128
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 154..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 174 AA; 19629 MW; 25CFEF7CBC0DAD6D CRC64;
MAPQQKGKQG TKGAKQIVEE NKGTLCFYRN MALGSAGASL LVNFIFFEVS KTTIFMSSLS
LVVLGAAYQF MTFMSRPKYS ETGSLLDSGN DLNMEGGLAE NVKDLIILTS GTMLLALISN
YFWLLLLLAP AQALWKLWGS FIKPWLSQRN ISEEPEMDEK KQRKMERKLR RSMR
//
