ID   A0A1B0G1C4_GLOMM        Unreviewed;       849 AA.
AC   A0A1B0G1C4;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   22-FEB-2023, entry version 24.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS   Glossina morsitans morsitans (Savannah tsetse fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC   Glossinidae; Glossina.
OX   NCBI_TaxID=37546 {ECO:0000313|EnsemblMetazoa:GMOY007072-PA, ECO:0000313|Proteomes:UP000092444};
RN   [1] {ECO:0000313|Proteomes:UP000092444}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Yale {ECO:0000313|Proteomes:UP000092444};
RA   Lawson D.;
RT   "Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African
RT   Trypanosomiasis.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000092444}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Yale {ECO:0000313|Proteomes:UP000092444};
RG   International Glossina Genome Initiative W.H.O.;
RA   Lawson D.;
RT   "Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African
RT   Trypanosomiasis.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EnsemblMetazoa:GMOY007072-PA}
RP   IDENTIFICATION.
RC   STRAIN=Yale {ECO:0000313|EnsemblMetazoa:GMOY007072-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC       multimeric enzyme that catalyzes the translocation of protons across
CC       the membranes. Required for assembly and activity of the V-ATPase.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; CCAG010023381; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A1B0G1C4; -.
DR   STRING; 37546.A0A1B0G1C4; -.
DR   EnsemblMetazoa; GMOY007072-RA; GMOY007072-PA; GMOY007072.
DR   VEuPathDB; VectorBase:GMOY007072; -.
DR   PhylomeDB; A0A1B0G1C4; -.
DR   Proteomes; UP000092444; Unassembled WGS sequence.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629:SF63; V-TYPE PROTON ATPASE SUBUNIT A; 1.
DR   PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW   ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM        421..449
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        469..489
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        559..577
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        592..612
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        624..643
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        663..682
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        784..808
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   COILED          51..128
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   849 AA;  97174 MW;  50BBD1E51360BECB CRC64;
     MGSLFRSEEM ALYQLFLQSE AAYACVSELG ELGLVQFRDL NPDVNAFQRK FVNEVRRCDE
     MERKLRYLEK EIKKDNIPMQ DTGESPEAPQ PREMIDLEAT FEKLENELRE VNQNAEALKR
     NYLELTELKH ILRKTQVFFD EMADNQNEDE QTQLLGEDGA KQDGRLTTTT ESMTRALVTD
     EVRTVHYLGP VQLGFVAGVI LREKLPAFER MLWRACRGNV FLRQAMIESH LEDPSSGDQV
     HKSVFIIFFQ GDQLKIRVKK ICEGFRATLY PCPEAPTDRR EMAMGVMTRI EDLNTVLGQT
     EDHRRRVLVA AAKNLKNWFV KVRKIKAIYH TLNLFNLDVT QKCLIAECWV PALDIETIHL
     ALRRGTERSG SSVPPILNRM QTYENPPTYN RTNKFTKAFQ ALIDAYGVAT YREMNPAPYT
     IITFPFLFAV MFGDLGHGAV MALFGLWMIR KEKGLAAQKT DSEIWNIFFG GRYIIFLMGV
     FSMYTGLIYN DIFSKSLNIF GSHWQITYNK STVISNKYLQ LNPETTDYTD TPYPFGMDPI
     WQVAGANKII FQNAYKMKIS IILGVIHMIF GVIMSYYNHT YFKNRLSLIY EFIPQMVFLL
     FLFFYMVLLM FIKWNRYSAK NYGRYSASCA PSILITFIDM VLFNTPKPVP EPCEVYMFGG
     QHFFQTIFVL VALACIPVML LAKPLNIMKQ RRQGNVQPIA AGSTSDVEVG MSNGQISQGV
     DHHEEEEISE IFIHQGIHTI EYVLGSVSHT ASYLRLWALS LAHAQLAEVL WNMVLSNGLK
     KENWFGGIIL TVVFAAWAVL TIGILVLMEG LSAVEFQSKF YQGKGYAFQP FSFESIVENS
     SSSSQTEGE
//