ID A0A1B0G4J9_GLOMM Unreviewed; 932 AA.
AC A0A1B0G4J9;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=Protein tweety homolog {ECO:0000256|RuleBase:RU361114};
OS Glossina morsitans morsitans (Savannah tsetse fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC Glossinidae; Glossina.
OX NCBI_TaxID=37546 {ECO:0000313|EnsemblMetazoa:GMOY008246-PA, ECO:0000313|Proteomes:UP000092444};
RN [1] {ECO:0000313|Proteomes:UP000092444}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Yale {ECO:0000313|Proteomes:UP000092444};
RA Lawson D.;
RT "Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African
RT Trypanosomiasis.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000092444}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Yale {ECO:0000313|Proteomes:UP000092444};
RG International Glossina Genome Initiative W.H.O.;
RA Lawson D.;
RT "Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African
RT Trypanosomiasis.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:GMOY008246-PA}
RP IDENTIFICATION.
RC STRAIN=Yale {ECO:0000313|EnsemblMetazoa:GMOY008246-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- FUNCTION: Probable chloride channel. {ECO:0000256|RuleBase:RU361114}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU361114};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU361114}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the tweety family.
CC {ECO:0000256|ARBA:ARBA00009849, ECO:0000256|RuleBase:RU361114}.
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DR EMBL; CCAG010009690; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A1B0G4J9; -.
DR EnsemblMetazoa; GMOY008246-RA; GMOY008246-PA; GMOY008246.
DR VEuPathDB; VectorBase:GMOY008246; -.
DR PhylomeDB; A0A1B0G4J9; -.
DR Proteomes; UP000092444; Unassembled WGS sequence.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005254; F:chloride channel activity; IEA:UniProtKB-UniRule.
DR CDD; cd07912; Tweety_N; 1.
DR InterPro; IPR006990; Tweety.
DR PANTHER; PTHR12424:SF8; PROTEIN TWEETY; 1.
DR PANTHER; PTHR12424; TWEETY-RELATED; 1.
DR Pfam; PF04906; Tweety; 1.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|RuleBase:RU361114};
KW Chloride channel {ECO:0000256|RuleBase:RU361114};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|RuleBase:RU361114};
KW Ion transport {ECO:0000256|RuleBase:RU361114};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361114};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361114};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361114};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361114}.
FT TRANSMEM 60..82
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361114"
FT TRANSMEM 102..121
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361114"
FT TRANSMEM 228..251
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361114"
FT TRANSMEM 258..280
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361114"
FT TRANSMEM 405..428
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361114"
FT REGION 516..568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 662..709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 836..932
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 516..562
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 862..903
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 932 AA; 102382 MW; F7A2AE97BEE7E552 CRC64;
MLLLSESGKT SKMAEYHEYT DQYRVPMIAK LLHALPHYNI TFHKINSTFR PNDEIYLESL
GILGSVPAAL LIISLLGLLL YLMTRCCDRK PRPAHSITSL KVALSIVTVM CCAAIGLGLY
GNDDLHNGLL EVLTAGRKVD TLVTTIRNQT HILENTLKNR IRPQLVELAD IFDQPVSNQS
ALSILFVSLN IVQGNVTLAT NAASDIRRPL TSVTMTKFLS DGDKMELIRW PGTVATLALL
LVLCAVLLVG VARHSRCALI LFSVCGLLAV TGSWLMSGLY LSSSVAVGDL CINPADFLVS
MSPRDLPTNV LLHYTQCEPG HTNPFTQRLR ESQNSLNNAR SAMATVMKIS LVLFKSSGLQ
PKLGAVNADL NSSERLLTQL TALVDCKAVH HSFLAAARGL CEGGLLGLVL MLVASFVAAI
LLTIMVWVDS HTWIYIRKRN DYAQVDEPSY ISHPAPQNHQ QVMNASRTLP RNHNGHFSPP
VISGSHTLQH PSKRQQHEMM SHAHMQQNIR AMGTHTLGRL PSHNHSPTQL TACSDTNSRS
QHGAAHQQQQ HPIQSSQQPI YCHYPHPHTH AAGVQHQHAI YHQQQQSQYG NYSTAVHPQQ
QQHLSVAGQQ NSIYQQIAPP HTAQLTQNGS HLTNQHSIYQ PLVAVSQGSI YVSNLATMRR
QNTQQNAANS QISTQLQHPQ QQSSGIQPTS HHQHQIKSPQ ETHNISRSDS IDNALYDREK
GVYKCSTLRQ GGKFDPKYKP SILNCPLPEI PKDAEPPTVE SIYHQQQKNY SKTLQRPTMK
LTPQMKAIPP PKVLTPTSPP LVENSVNAVA VACKNQNQSN SIQIRGNMAT NIAAANDAKQ
SPSNESALPP PPPIEPDIGS PSSKMIPTSN INNNNNNNNN NNNNNNNNNN GSSDSMPNGH
TANHTINDDD ELPPPPPPPA INDESNYAVT EL
//
