ID   A0A1B0G565_GLOMM        Unreviewed;       710 AA.
AC   A0A1B0G565;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:GMOY008461-PA};
OS   Glossina morsitans morsitans (Savannah tsetse fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC   Glossinidae; Glossina.
OX   NCBI_TaxID=37546 {ECO:0000313|EnsemblMetazoa:GMOY008461-PA, ECO:0000313|Proteomes:UP000092444};
RN   [1] {ECO:0000313|Proteomes:UP000092444}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Yale {ECO:0000313|Proteomes:UP000092444};
RG   International Glossina Genome Initiative W.H.O.;
RA   Lawson D.;
RT   "Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African
RT   Trypanosomiasis.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000092444}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Yale {ECO:0000313|Proteomes:UP000092444};
RA   Lawson D.;
RT   "Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African
RT   Trypanosomiasis.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EnsemblMetazoa:GMOY008461-PA}
RP   IDENTIFICATION.
RC   STRAIN=Yale {ECO:0000313|EnsemblMetazoa:GMOY008461-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase M24B family.
CC       {ECO:0000256|ARBA:ARBA00008766}.
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DR   EMBL; CCAG010016580; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A1B0G565; -.
DR   STRING; 37546.A0A1B0G565; -.
DR   EnsemblMetazoa; GMOY008461-RA; GMOY008461-PA; GMOY008461.
DR   VEuPathDB; VectorBase:GMOY008461; -.
DR   PhylomeDB; A0A1B0G565; -.
DR   Proteomes; UP000092444; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004177; F:aminopeptidase activity; IEA:UniProt.
DR   Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR   Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 2.
DR   InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR   InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR   InterPro; IPR000587; Creatinase_N.
DR   InterPro; IPR000994; Pept_M24.
DR   InterPro; IPR032416; Peptidase_M24_C.
DR   PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR   PANTHER; PTHR43763:SF4; XAA-PRO AMINOPEPTIDASE 2; 1.
DR   Pfam; PF01321; Creatinase_N; 1.
DR   Pfam; PF16189; Creatinase_N_2; 1.
DR   Pfam; PF00557; Peptidase_M24; 1.
DR   Pfam; PF16188; Peptidase_M24_C; 1.
DR   SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR   SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..710
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5008407909"
FT   TRANSMEM        686..709
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          95..192
FT                   /note="Creatinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01321"
FT   DOMAIN          376..590
FT                   /note="Peptidase M24"
FT                   /evidence="ECO:0000259|Pfam:PF00557"
FT   DOMAIN          601..665
FT                   /note="Peptidase M24 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16188"
SQ   SEQUENCE   710 AA;  82310 MW;  B4883908127175BB CRC64;
     MKSVQWFHWF VILTLCVLPS SIAKINEFRG HTREICKYRK GKLVLIGHIP FSEHRRRLFA
     VREQMQIHAS LEGPEIHAYI LPSYDEHLNH EVAASDQRLQ YLTGFTGTKA FAAITQKGAA
     LWVESRYLQQ ADGELDCDWE LFRVNDSITI ADWLDDQLHP DKRVGADPHL VPHYLWMKWE
     NQLKDKFLAL TKINNNLIDL IWGEERPETL NITIQVWERS YAGEKWEDKI LELRQKLYYH
     KCDAMIVTSL TEIAYLLNVR GRDIPYTPVV KSYLIVSHQD IFFYVDRLKM TLGLNWHLRT
     DCFNEMCVKI KEYHQVWSDM RTYSQIWKRV LVPARCVQEP GASEAIFSAF PLKIIYEHIS
     PVILMRAQKN SVEQDGMRTA HVRDGAAICE AISNLEMRFF TEQWTEEKIK FEVERSRLSQ
     NHAKGLSMRT VVAYGEHSSY PYYISSNVTD VEVTDQSFLV IESGGQYYEG TTDVSRTFLF
     GQPTPEMKQS YTMVLAGILR LAHLKFPSNL RLSEVDALVR SPIWESMSDY PQATGHGIGS
     YNAVEEPPIS VAYGQESHFH FKEGYFFSSE SGYYKPGEYG VRLKNVLEVK DTQRGHPSGA
     TFLAFHDVTL VPYEPKLIDG TLLSALEKRW LNEYNAKIRE LVGDELKRQG NMQAFYWMMN
     KTRHIREYLP EEEYRAATGT GNRSRAFLTI IVPAILLGLT VFGSFLRWLL
//