ID A0A1B0GCP2_GLOMM Unreviewed; 1172 AA.
AC A0A1B0GCP2;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 13-SEP-2023, entry version 31.
DE RecName: Full=Formin-like protein {ECO:0008006|Google:ProtNLM};
OS Glossina morsitans morsitans (Savannah tsetse fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC Glossinidae; Glossina.
OX NCBI_TaxID=37546 {ECO:0000313|EnsemblMetazoa:GMOY011068-PA, ECO:0000313|Proteomes:UP000092444};
RN [1] {ECO:0000313|Proteomes:UP000092444}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Yale {ECO:0000313|Proteomes:UP000092444};
RA Lawson D.;
RT "Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African
RT Trypanosomiasis.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000092444}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Yale {ECO:0000313|Proteomes:UP000092444};
RG International Glossina Genome Initiative W.H.O.;
RA Lawson D.;
RT "Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African
RT Trypanosomiasis.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:GMOY011068-PA}
RP IDENTIFICATION.
RC STRAIN=Yale {ECO:0000313|EnsemblMetazoa:GMOY011068-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the formin homology family.
CC {ECO:0000256|ARBA:ARBA00023449}.
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DR EMBL; CCAG010002176; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A1B0GCP2; -.
DR STRING; 37546.A0A1B0GCP2; -.
DR EnsemblMetazoa; GMOY011068-RA; GMOY011068-PA; GMOY011068.
DR VEuPathDB; VectorBase:GMOY011068; -.
DR PhylomeDB; A0A1B0GCP2; -.
DR Proteomes; UP000092444; Unassembled WGS sequence.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR GO; GO:0022604; P:regulation of cell morphogenesis; IEA:InterPro.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR014767; DAD_dom.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR010472; FH3_dom.
DR InterPro; IPR043592; FMNL_animal.
DR InterPro; IPR014768; GBD/FH3_dom.
DR InterPro; IPR010473; GTPase-bd.
DR PANTHER; PTHR45857; FORMIN-LIKE PROTEIN; 1.
DR PANTHER; PTHR45857:SF4; FORMIN-LIKE PROTEIN; 1.
DR Pfam; PF06367; Drf_FH3; 1.
DR Pfam; PF06371; Drf_GBD; 2.
DR Pfam; PF02181; FH2; 1.
DR SMART; SM01139; Drf_FH3; 1.
DR SMART; SM01140; Drf_GBD; 1.
DR SMART; SM00498; FH2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51231; DAD; 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51232; GBD_FH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}.
FT DOMAIN 75..536
FT /note="GBD/FH3"
FT /evidence="ECO:0000259|PROSITE:PS51232"
FT DOMAIN 684..1086
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT DOMAIN 1125..1158
FT /note="DAD"
FT /evidence="ECO:0000259|PROSITE:PS51231"
FT REGION 61..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 577..653
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 462..517
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1063..1102
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 61..78
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 583..626
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 633..647
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1172 AA; 133309 MW; B2991102B2AA1058 CRC64;
MGSVKSRTLI STDNLIDDSN VVCGASSYYQ QHQMKGAASG NGTGLLQKRD LRYDIGTSSQ
YHPIRQPSVR NRPQQPMPTT DELDRRFAKV LASMDLPPDK AKLLKNYDDE KKWDIICDQE
MVQAKDPPSH YLNKLRTYLD PKASRSHRKR KIVGESTSTQ VLRDLEISLR TNHIEWVKEF
LDETNQGLDA LVDYLSFRLQ MMRHEQRIQE ALSESDERLD LNNTSVGNVM GDCAENTAHG
VINNSNLLES SRHQSLHSSS FSGLTNGFLR PSLGDVLDSP SIKRRSRHIA KLNMGASTDD
IHVCIMCLRA IMNNKYGFNM VIQHREAINC IALSLIHKSL RTKALVLELL AAICLVKGGH
EIILYSFDNF KSVCHEKRRF QTLMEYFMNF EAFNIDFMVA CMQFMNIVVH SVEDMNYRVH
LQYEFTALGL DKYLEKLRLT ESEELKVQIS AYLDNVFDVA ALMEDSETKT AALERVQELE
DQVEREIDRN SELLYKLAEM ETEVAYLKAE REELLTTKLK FDEEVTTLRR ILKQNEQELK
RRDSLLQSKN LELQTLTRSL PRSVSNAEGS QLSELSANLL PPKCDSPPLP PPPPPLPSSQ
VIGTVTSPPP PPPPAPPAPP PPPLSGCQST TMNRAPPPPP PVPSDGPSMR TFPQHQVNPV
LSAFQPPPPP VAGFMPAPDG AMTIKRKVPT KYKLPTLNWI ALKPNQVRGT IFNELDDEKI
YKYIDFNEFE ERFKIGIGGP LTNGTNSEVD GNLQSYPSKR FKKPDNVSLL EHTRLRNIAI
SRRKLDMPID EVIAAIHSLD LKKLSLENVE LLQKMVPTDV EVKAYKEYII ERKDQNLLSE
EDKFMLQLSK VERISSKLSI MNYMGNFFDC LHLISPQIQS ITAASNSLKQ SRKFKAVLEI
VLAFGNYLNS SKRGPAYGFK LQSLDTLIDT KSTDKRLSLL HYIVATIRQK FPELLSFETE
LFCTDKASQV SLENIVTDVH DLEKGMDLVK KEAELRVKGV QTHILRDFLN NSEDKLKKIK
IELKNAQEAF KECVEYFGES SRNADAAAFF ALIVRFTRAF KSHDQENEQR RRLEQAAAAA
AASKKENEQV QLRNKVNQKK QQDAVINELK CKTNSVREKK LLQQDEVYNG ALEDILLGLK
SEPYRRADAV RRSQRRRIDN NRLSRTLEEL DV
//
