ID A0A1B0GDV5_GLOMM Unreviewed; 113 AA.
AC A0A1B0GDV5;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2023, sequence version 2.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Mitochondrial import inner membrane translocase subunit {ECO:0000256|RuleBase:RU367043};
OS Glossina morsitans morsitans (Savannah tsetse fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Hippoboscoidea;
OC Glossinidae; Glossina.
OX NCBI_TaxID=37546 {ECO:0000313|EnsemblMetazoa:GMOY011479-PA, ECO:0000313|Proteomes:UP000092444};
RN [1] {ECO:0000313|Proteomes:UP000092444}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Yale {ECO:0000313|Proteomes:UP000092444};
RA Lawson D.;
RT "Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African
RT Trypanosomiasis.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000092444}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Yale {ECO:0000313|Proteomes:UP000092444};
RG International Glossina Genome Initiative W.H.O.;
RA Lawson D.;
RT "Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African
RT Trypanosomiasis.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:GMOY011479-PA}
RP IDENTIFICATION.
RC STRAIN=Yale {ECO:0000313|EnsemblMetazoa:GMOY011479-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- FUNCTION: Mitochondrial intermembrane chaperone that participates in
CC the import and insertion of some multi-pass transmembrane proteins into
CC the mitochondrial inner membrane. Also required for the transfer of
CC beta-barrel precursors from the TOM complex to the sorting and assembly
CC machinery (SAM complex) of the outer membrane. Acts as a chaperone-like
CC protein that protects the hydrophobic precursors from aggregation and
CC guide them through the mitochondrial intermembrane space.
CC {ECO:0000256|RuleBase:RU367043}.
CC -!- SUBUNIT: Heterohexamer. {ECO:0000256|RuleBase:RU367043}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC Mitochondrion inner membrane {ECO:0000256|RuleBase:RU367043};
CC Peripheral membrane protein {ECO:0000256|RuleBase:RU367043};
CC Intermembrane side {ECO:0000256|RuleBase:RU367043}.
CC -!- DOMAIN: The twin CX3C motif contains 4 conserved Cys residues that form
CC 2 disulfide bonds in the mitochondrial intermembrane space.
CC {ECO:0000256|RuleBase:RU367043}.
CC -!- SIMILARITY: Belongs to the small Tim family.
CC {ECO:0000256|RuleBase:RU367043}.
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DR EMBL; CCAG010012029; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A1B0GDV5; -.
DR STRING; 37546.A0A1B0GDV5; -.
DR EnsemblMetazoa; GMOY011479-RA; GMOY011479-PA; GMOY011479.
DR PhylomeDB; A0A1B0GDV5; -.
DR Proteomes; UP000092444; Unassembled WGS sequence.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 1.10.287.810; Mitochondrial import inner membrane translocase subunit tim13 like domains; 1.
DR InterPro; IPR004217; Tim10-like.
DR InterPro; IPR035427; Tim10-like_dom_sf.
DR PANTHER; PTHR13172:SF0; MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10 B; 1.
DR PANTHER; PTHR13172; MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9B; 1.
DR Pfam; PF02953; zf-Tim10_DDP; 1.
DR SUPFAM; SSF144122; Tim10-like; 1.
PE 3: Inferred from homology;
KW Chaperone {ECO:0000256|RuleBase:RU367043};
KW Disulfide bond {ECO:0000256|RuleBase:RU367043};
KW Membrane {ECO:0000256|RuleBase:RU367043};
KW Mitochondrion {ECO:0000256|RuleBase:RU367043};
KW Mitochondrion inner membrane {ECO:0000256|RuleBase:RU367043};
KW Protein transport {ECO:0000256|RuleBase:RU367043};
KW Translocation {ECO:0000256|RuleBase:RU367043};
KW Transport {ECO:0000256|RuleBase:RU367043}.
FT DOMAIN 6..62
FT /note="Tim10-like"
FT /evidence="ECO:0000259|Pfam:PF02953"
FT REGION 93..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 113 AA; 13134 MW; 23AD94D7067AA5E0 CRC64;
MDPNLRNLKD FLTLYNKITE LCFGRCVDNF NGRVLSNTEN ICVNHCVNKF ARFNQAMMKV
YVEVQTQLNQ KRLKELEEQQ KLLDQKSLQL PISTTEQSAP LRTDQTITEN LPA
//
