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Database: UniProt
Entry: A0A1B0GG33_GLOMM
LinkDB: A0A1B0GG33_GLOMM
Original site: A0A1B0GG33_GLOMM 
ID   A0A1B0GG33_GLOMM        Unreviewed;       715 AA.
AC   A0A1B0GG33;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   18-SEP-2019, entry version 16.
DE   SubName: Full=Nicotinic-acetylcholine receptor alpha {ECO:0000313|VectorBase:GMOY012307-PA};
OS   Glossina morsitans morsitans (Savannah tsetse fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Hippoboscoidea; Glossinidae; Glossina.
OX   NCBI_TaxID=37546 {ECO:0000313|Proteomes:UP000092444, ECO:0000313|VectorBase:GMOY012307-PA};
RN   [1] {ECO:0000313|Proteomes:UP000092444, ECO:0000313|VectorBase:GMOY012307-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Yale {ECO:0000313|Proteomes:UP000092444,
RC   ECO:0000313|VectorBase:GMOY012307-PA};
RA   Lawson D.;
RT   "Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of
RT   African Trypanosomiasis.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000092444, ECO:0000313|VectorBase:GMOY012307-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Yale {ECO:0000313|Proteomes:UP000092444,
RC   ECO:0000313|VectorBase:GMOY012307-PA};
RG   International Glossina Genome Initiative W.H.O.;
RA   Lawson D.;
RT   "Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of
RT   African Trypanosomiasis.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|VectorBase:GMOY012307-PA}
RP   IDENTIFICATION.
RC   STRAIN=Yale {ECO:0000313|VectorBase:GMOY012307-PA};
RG   VectorBase;
RL   Submitted (JUL-2016) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9)
CC       family. {ECO:0000256|RuleBase:RU000687,
CC       ECO:0000256|SAAS:SAAS00978283}.
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DR   EMBL; CCAG010023723; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   VectorBase; GMOY012307-RA; GMOY012307-PA; GMOY012307.
DR   Proteomes; UP000092444; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   Gene3D; 2.70.170.10; -; 1.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR   InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR   InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR   PANTHER; PTHR18945; PTHR18945; 2.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   Pfam; PF02932; Neur_chan_memb; 2.
DR   PRINTS; PR00252; NRIONCHANNEL.
DR   SUPFAM; SSF63712; SSF63712; 1.
DR   SUPFAM; SSF90112; SSF90112; 1.
DR   PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000092444};
KW   Ion channel {ECO:0000256|RuleBase:RU000687};
KW   Ion transport {ECO:0000256|RuleBase:RU000687};
KW   Membrane {ECO:0000256|SAAS:SAAS00978300, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000092444};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00978734,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00978768,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000687}.
FT   TRANSMEM    251    270       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    492    514       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    689    713       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      332    491       Neur_chan_LBD. {ECO:0000259|Pfam:
FT                                PF02931}.
FT   DOMAIN      489    538       Neur_chan_memb. {ECO:0000259|Pfam:
FT                                PF02932}.
FT   DOMAIN      646    705       Neur_chan_memb. {ECO:0000259|Pfam:
FT                                PF02932}.
FT   REGION      198    233       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    198    214       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   715 AA;  83289 MW;  93EC36A24FF1E38A CRC64;
     MLLHHDLYKR QLYLTPKTCR RKSMKSFKVL SSHRKKCNFQ YFKSKEKPPS IQQQQHSRRL
     FFQNQETCNL TTINNGNSYK ATAGQQKEMQ DNQQAKQRQH CENYNLRLGL RKRRLRRKRK
     RKSFQKLTTA LAIQRQIILS VPSSKESTAV DIVTNNKSFQ TNETMEQLPL QQYQGDHYHH
     HRQKQHGYHR LHHQYFKHQY QQEHHQQQKQ QQERQRHRQR QRQRQHQQQQ QQTETNLALN
     LRQRLNNSIT MFNLITVHLL TAVTVFYANI STIMSTTTEH IESVAIAATT LPNQLIQQLL
     NIQQLPLQLL RQLSYCHCRC LTKCTSCCSS PLLHDLLDTY NTLERPVLNE SDPLQLSFGL
     TLMQIIDVEW NDMNLRWNTS DYGGIKDLRI PPHRIWKPDV LMYNSADEGF DGTYQTNVVV
     RNNGSCLYVP PGIFKSTCKI DITWFPFDDQ RCEMKFGSWT YDGFQLDLQL QDETGGDISS
     YVLNGEWELL GTYFNCIMFM VASSVVSTIL ILNYHHRNAD THEMSEWVSF LFLLLLKKKK
     LYTCGILMLA AMDLTYASSG QTYNIGFFVY PVLGYLIRTS SKSLLANVLD IDDDFRNCRP
     MTPGGTLPHN PAFYRTVYGQ GDDGSIGPIG STRMPDAVTH HSCIKSSTEY ELSLILKEIR
     FITDQLRKED EEDDIANDWK FAAMVVDRLC LIIFTMFTIL ATIAVLLSAP HIIVS
//
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