ID A0A1B0GHL0_LUTLO Unreviewed; 788 AA.
AC A0A1B0GHL0;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 22-FEB-2023, entry version 21.
DE SubName: Full=Putative tyrosine transporter {ECO:0000313|EMBL:MBC1178371.1};
OS Lutzomyia longipalpis (Sand fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Psychodoidea; Psychodidae;
OC Lutzomyia; Lutzomyia.
OX NCBI_TaxID=7200 {ECO:0000313|EnsemblMetazoa:LLOJ001527-PA, ECO:0000313|Proteomes:UP000092461};
RN [1] {ECO:0000313|Proteomes:UP000092461}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Jacobina {ECO:0000313|Proteomes:UP000092461};
RA Richards S., Qu C., Dillon R., Worley K., Scherer S., Batterton M.,
RA Taylor A., Hawes A., Hernandez B., Kovar C., Mandapat C., Pham C., Qu C.,
RA Jing C., Bess C., Bandaranaike D., Ngo D., Ongeri F., Arias F., Lara F.,
RA Weissenberger G., Kamau G., Han H., Shen H., Dinh H., Khalil I., Jones J.,
RA Shafer J., Jayaseelan J., Quiroz J., Blankenburg K., Nguyen L., Jackson L.,
RA Francisco L., Tang L.-Y., Pu L.-L., Perales L., Lorensuhewa L.,
RA Munidasa M., Coyle M., Taylor M., Puazo M., Firestine M., Scheel M.,
RA Javaid M., Wang M., Li M., Tabassum N., Saada N., Osuji N., Aqrawi P.,
RA Fu Q., Thornton R., Raj R., Goodspeed R., Mata R., Najjar R., Gubbala S.,
RA Lee S., Denson S., Patil S., Macmil S., Qi S., Matskevitch T.,
RA Palculict T., Mathew T., Vee V., Velamala V., Korchina V., Cai W., Liu W.,
RA Dai W., Zou X., Zhu Y., Zhang Y., Wu Y.-Q., Xin Y., Nazarath L., Kovar C.,
RA Han Y., Muzny D., Gibbs R.;
RT "Whole Genome Assembly of Lutzomyia longipalpis.";
RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:MBC1178371.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Jacobina {ECO:0000313|EMBL:MBC1178371.1};
RC TISSUE=Midgut {ECO:0000313|EMBL:MBC1178371.1};
RA Coutinho-Abreu I.V., Serafim T.D., Meneses C., Kamhawi S., Oliveira F.,
RA Valenzuela J.G.;
RT "Leishmania infection induces a limited differential gene expression in the
RT sand fly midgut.";
RL BMC 21:608-608(2020).
RN [3] {ECO:0000313|EnsemblMetazoa:LLOJ001527-PA}
RP IDENTIFICATION.
RC STRAIN=Jacobina {ECO:0000313|EnsemblMetazoa:LLOJ001527-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane, sarcolemma
CC {ECO:0000256|ARBA:ARBA00004274}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004274}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
CC {ECO:0000256|ARBA:ARBA00007574}.
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DR EMBL; AJWK01005308; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJWK01005309; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJWK01005310; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GITU01009668; MBC1178371.1; -; Transcribed_RNA.
DR AlphaFoldDB; A0A1B0GHL0; -.
DR EnsemblMetazoa; LLOJ001527-RA; LLOJ001527-PA; LLOJ001527.
DR VEuPathDB; VectorBase:LLOJ001527; -.
DR OrthoDB; 5481761at2759; -.
DR Proteomes; UP000092461; Unassembled WGS sequence.
DR GO; GO:0016012; C:sarcoglycan complex; IEA:InterPro.
DR GO; GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR CDD; cd01116; P_permease; 1.
DR InterPro; IPR004680; Cit_transptr-like_dom.
DR InterPro; IPR006875; Sarcoglycan.
DR PANTHER; PTHR43568; P PROTEIN; 1.
DR PANTHER; PTHR43568:SF1; P PROTEIN; 1.
DR Pfam; PF03600; CitMHS; 1.
DR Pfam; PF04790; Sarcoglycan_1; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 67..93
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 164..188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 304..320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 326..343
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 355..375
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 395..417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 438..458
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 478..498
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 572..592
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 598..617
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 629..649
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 669..689
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 758..785
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 315..725
FT /note="Citrate transporter-like"
FT /evidence="ECO:0000259|Pfam:PF03600"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 788 AA; 87162 MW; 04D426130A6FC143 CRC64;
MASLDNTFMR SASPQFSDDG DDSGMATLPI GDVSSYPQST THTYNPQRAN YLPEKEKDYL
KGRNTCAFWI LVILLIILTI GNLALTLTIV GILRLGRGMQ FMELVPEADT LARNMDARGS
SGAMVVESTE MDVLTEEAIK STGSHEGDDE AKPAAGDAPR ASRLYLVGLH VKIAFLTICW
VYFVWMLLVN GEKEVQFVGL TVPMDGREVQ ISSEPFVLLL NGPFHQDAER MGGYYLFVSA
GTNGSGDVWR VPVVRDLEKS PPHTLRQSFI PPEGGVIRLW TNMSSGIFIR MGVDLAVFDE
VHGVVYATLI LIILYALIIW DVVHRTFAAI LMSTLAIGVL AMLGDRPTAQ EVISWIDYET
ILLLFSMMIF VSVMSETGIF DYAAVRTFQL TNGRIWPLIH GLCFVTLAIS AFLDNVTTIL
LMTPITIRLC ELMKLKPAPV LMAIVVHANI GGTATPVGDP PNVIITSNHF IATNGVTFLT
FTSHMATGVI FVVVQTLLQL RMLFRDVNTL RMAVPEDIEK LKRELHIAPA TEQPQLRRQL
KKLSTRGIVN RDEYMRTLQE LESLYSIRNK PLLIKSTICL AFIIILFFVQ SIPSIHSISV
AWVALLGMLL LLILHNVSNM EEILAKVEWA TLLFFAAMFI LMECLSRLGL IRWIGVQTER
LILAVPSHYQ LAMAIIIILW VSALVSAFVD SIPVTTMMVR IVVAMAQNPK LTLPLQPLVW
ALAFGPCLGG NGTLVGASAN VVCAALAQQR GHIITFRAFL RFGFPLMLGS VLVTTGYLLL
AHVVFSWH
//
