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Database: UniProt
Entry: A0A1B0GJQ9_LUTLO
LinkDB: A0A1B0GJQ9_LUTLO
Original site: A0A1B0GJQ9_LUTLO 
ID   A0A1B0GJQ9_LUTLO        Unreviewed;      1418 AA.
AC   A0A1B0GJQ9;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   08-NOV-2023, entry version 36.
DE   RecName: Full=PDZ domain-containing protein 8 {ECO:0008006|Google:ProtNLM};
OS   Lutzomyia longipalpis (Sand fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Psychodoidea; Psychodidae;
OC   Lutzomyia; Lutzomyia.
OX   NCBI_TaxID=7200 {ECO:0000313|EnsemblMetazoa:LLOJ006698-PA, ECO:0000313|Proteomes:UP000092461};
RN   [1] {ECO:0000313|Proteomes:UP000092461}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Jacobina {ECO:0000313|Proteomes:UP000092461};
RA   Richards S., Qu C., Dillon R., Worley K., Scherer S., Batterton M.,
RA   Taylor A., Hawes A., Hernandez B., Kovar C., Mandapat C., Pham C., Qu C.,
RA   Jing C., Bess C., Bandaranaike D., Ngo D., Ongeri F., Arias F., Lara F.,
RA   Weissenberger G., Kamau G., Han H., Shen H., Dinh H., Khalil I., Jones J.,
RA   Shafer J., Jayaseelan J., Quiroz J., Blankenburg K., Nguyen L., Jackson L.,
RA   Francisco L., Tang L.-Y., Pu L.-L., Perales L., Lorensuhewa L.,
RA   Munidasa M., Coyle M., Taylor M., Puazo M., Firestine M., Scheel M.,
RA   Javaid M., Wang M., Li M., Tabassum N., Saada N., Osuji N., Aqrawi P.,
RA   Fu Q., Thornton R., Raj R., Goodspeed R., Mata R., Najjar R., Gubbala S.,
RA   Lee S., Denson S., Patil S., Macmil S., Qi S., Matskevitch T.,
RA   Palculict T., Mathew T., Vee V., Velamala V., Korchina V., Cai W., Liu W.,
RA   Dai W., Zou X., Zhu Y., Zhang Y., Wu Y.-Q., Xin Y., Nazarath L., Kovar C.,
RA   Han Y., Muzny D., Gibbs R.;
RT   "Whole Genome Assembly of Lutzomyia longipalpis.";
RL   Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:MBC1175736.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Jacobina {ECO:0000313|EMBL:MBC1175736.1};
RC   TISSUE=Midgut {ECO:0000313|EMBL:MBC1175736.1};
RA   Coutinho-Abreu I.V., Serafim T.D., Meneses C., Kamhawi S., Oliveira F.,
RA   Valenzuela J.G.;
RT   "Leishmania infection induces a limited differential gene expression in the
RT   sand fly midgut.";
RL   BMC 21:608-608(2020).
RN   [3] {ECO:0000313|EnsemblMetazoa:LLOJ006698-PA}
RP   IDENTIFICATION.
RC   STRAIN=Jacobina {ECO:0000313|EnsemblMetazoa:LLOJ006698-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
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DR   EMBL; AJWK01022089; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AJWK01022090; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; GITU01007033; MBC1175736.1; -; Transcribed_RNA.
DR   EnsemblMetazoa; LLOJ006698-RA; LLOJ006698-PA; LLOJ006698.
DR   VEuPathDB; VectorBase:LLOJ006698; -.
DR   OrthoDB; 3681901at2759; -.
DR   Proteomes; UP000092461; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0044233; C:mitochondria-associated endoplasmic reticulum membrane; IEA:InterPro.
DR   GO; GO:0005739; C:mitochondrion; IEA:GOC.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   GO; GO:0051560; P:mitochondrial calcium ion homeostasis; IEA:InterPro.
DR   GO; GO:1990456; P:mitochondrion-endoplasmic reticulum membrane tethering; IEA:InterPro.
DR   CDD; cd20825; C1_PDZD8; 2.
DR   CDD; cd00987; PDZ_serine_protease; 1.
DR   CDD; cd21674; SMP_PDZD8; 1.
DR   Gene3D; 2.30.42.10; -; 2.
DR   Gene3D; 3.30.60.20; -; 2.
DR   InterPro; IPR046349; C1-like_sf.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR041489; PDZ_6.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR039275; PDZD8.
DR   InterPro; IPR002219; PE/DAG-bd.
DR   InterPro; IPR031468; SMP_LBD.
DR   PANTHER; PTHR21519; PDZ DOMAIN-CONTAINING PROTEIN 8; 1.
DR   PANTHER; PTHR21519:SF1; PDZ DOMAIN-CONTAINING PROTEIN 8; 1.
DR   Pfam; PF13180; PDZ_2; 1.
DR   Pfam; PF17820; PDZ_6; 1.
DR   SMART; SM00109; C1; 2.
DR   SMART; SM00228; PDZ; 2.
DR   SUPFAM; SSF57889; Cysteine-rich domain; 2.
DR   SUPFAM; SSF50156; PDZ domain-like; 2.
DR   PROSITE; PS50106; PDZ; 1.
DR   PROSITE; PS51847; SMP; 1.
DR   PROSITE; PS00479; ZF_DAG_PE_1; 2.
DR   PROSITE; PS50081; ZF_DAG_PE_2; 2.
PE   4: Predicted;
KW   Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW   Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00023055};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   TRANSMEM        7..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          63..257
FT                   /note="SMP-LTD"
FT                   /evidence="ECO:0000259|PROSITE:PS51847"
FT   DOMAIN          323..380
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          649..699
FT                   /note="Phorbol-ester/DAG-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50081"
FT   DOMAIN          1097..1147
FT                   /note="Phorbol-ester/DAG-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50081"
FT   REGION          441..496
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          612..650
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          909..964
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1062..1098
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1346..1374
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        612..633
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        634..650
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1062..1081
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1082..1098
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1418 AA;  158395 MW;  806B3C29CF02F47F CRC64;
     MDVVDILLFC FISCVIGAVL MLLGQYYVFV RFIETPNETE ESTSITQKFE LPDSVLSSIK
     SSESESKNPI VAINLVLQFL FYELRHSNRV RKWFYRKLSL ELDELLTKST TGRLFDKLTI
     RELELGGQFP DIKSLRVNNV ELHDAEGYIE NLDVMLDLSY RGNFRLSIDA DMVLGKKGFL
     SVRVKHIAGL ARLQFTRKPY THWSLSFVGD PQVDLGIESQ FQGRQMQSNV TSFISNQIRK
     AIRSKHTLPS YKLRYKPFFQ KIDDDLDASD TIPEGTLTVN ICEVSRLNVP TQITSIFCSL
     TLASMPWAEA RQQDERTIIL SLDVEIHKAK NQQIGISFKQ IENAVMIDAI IPNTPAAKAN
     LKKRDILISI EGKKVNHLTH VSKILKGINR PMFLLRIQRS AQGVIKNDAV QEEFEIIESI
     DDGNISFSKA SDSVQIGTKI TRMNSLERNS SDSSVSNTPT NTPRKSGSSG NPLLRSKSRS
     VSVENEPKSP SKIPNPEIFQ QQTTTECPFN SFMRMEQVCT FNLKENLVYL NLNVFGQTKD
     ETIFLGYHNI FVPSILSECN ESTMGHYLKR FNLTAPEAPN LVTHPLSSQS GFESRLCYGD
     VLISFAWSDF SASPASTSQP TDAKRGKYSG SRTGSTDKLE EDRSESQKQH NFIRTHFNRA
     TQCDFCGKKI WLKDAAQCKE CSMCCHKKCI TKCQNSTVCG PVDAQVPISS PQQTVQPEFR
     VTNHGFLSVR VKHIAGLARL QFTRKPYTHW SLSFVGDPQV DLGIESQFQG RQMQSNVTSF
     ISNQIRKAIR SKHTLPSYKL RYKPFFQKID DDLDTSDTIP EGTLTVNICE QIENAVMIDA
     IIPNTPAAKA NLKKRDILIS IEGKKVNHLT HVSKILKVQE EFEIIESIDD GNISFSKASD
     SVQIGTKITR MNSLERNSSD SSVSNTPTNT PRKSGSSGNP LLRSKSRSVS VENEPKSPSK
     IPNPEIFQQQ TTTECPFNSF MRMEQTKDET IFLGYHNIFV PSILSECNES TMGHYLKRFN
     LTAPEAPNLV THPLSSQSGF ESRLCYGDVL ISFAWSDFNA SPAGTSQPTD TKRGKYSGSR
     TGSTDKLEED RSESQKQHNF IRTHFNRATQ CDFCGKKIWL KDAAQCKECS MCCHKKCITK
     CQNSTVCGPV DAQVPISSPQ QTVQPEFRVT QPCEEVNEGD DPEEINRLKS DGHRQSFSDL
     LTQGLKRVNS ANNLAIPAIV SSLGQGSRSL PPSPQYTPRK QSLVQATNPL AQAIHRLEAA
     SLTDIPGKQM SEKIDGIVEP FSGTPLDEIM TLAKTSSLQL YTELEPAKRV DKINEVLAKL
     RLALDMETTT HADLSMASAE LRTAKLSKVE SPRVSSDANH GGKGSDARKA ASREKEAEAE
     MARIAFLLGQ SEERVQALSV IMLHLCSALQ HAQSIASP
//
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