ID A0A1B0GJQ9_LUTLO Unreviewed; 1418 AA.
AC A0A1B0GJQ9;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 08-NOV-2023, entry version 36.
DE RecName: Full=PDZ domain-containing protein 8 {ECO:0008006|Google:ProtNLM};
OS Lutzomyia longipalpis (Sand fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Psychodoidea; Psychodidae;
OC Lutzomyia; Lutzomyia.
OX NCBI_TaxID=7200 {ECO:0000313|EnsemblMetazoa:LLOJ006698-PA, ECO:0000313|Proteomes:UP000092461};
RN [1] {ECO:0000313|Proteomes:UP000092461}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Jacobina {ECO:0000313|Proteomes:UP000092461};
RA Richards S., Qu C., Dillon R., Worley K., Scherer S., Batterton M.,
RA Taylor A., Hawes A., Hernandez B., Kovar C., Mandapat C., Pham C., Qu C.,
RA Jing C., Bess C., Bandaranaike D., Ngo D., Ongeri F., Arias F., Lara F.,
RA Weissenberger G., Kamau G., Han H., Shen H., Dinh H., Khalil I., Jones J.,
RA Shafer J., Jayaseelan J., Quiroz J., Blankenburg K., Nguyen L., Jackson L.,
RA Francisco L., Tang L.-Y., Pu L.-L., Perales L., Lorensuhewa L.,
RA Munidasa M., Coyle M., Taylor M., Puazo M., Firestine M., Scheel M.,
RA Javaid M., Wang M., Li M., Tabassum N., Saada N., Osuji N., Aqrawi P.,
RA Fu Q., Thornton R., Raj R., Goodspeed R., Mata R., Najjar R., Gubbala S.,
RA Lee S., Denson S., Patil S., Macmil S., Qi S., Matskevitch T.,
RA Palculict T., Mathew T., Vee V., Velamala V., Korchina V., Cai W., Liu W.,
RA Dai W., Zou X., Zhu Y., Zhang Y., Wu Y.-Q., Xin Y., Nazarath L., Kovar C.,
RA Han Y., Muzny D., Gibbs R.;
RT "Whole Genome Assembly of Lutzomyia longipalpis.";
RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:MBC1175736.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Jacobina {ECO:0000313|EMBL:MBC1175736.1};
RC TISSUE=Midgut {ECO:0000313|EMBL:MBC1175736.1};
RA Coutinho-Abreu I.V., Serafim T.D., Meneses C., Kamhawi S., Oliveira F.,
RA Valenzuela J.G.;
RT "Leishmania infection induces a limited differential gene expression in the
RT sand fly midgut.";
RL BMC 21:608-608(2020).
RN [3] {ECO:0000313|EnsemblMetazoa:LLOJ006698-PA}
RP IDENTIFICATION.
RC STRAIN=Jacobina {ECO:0000313|EnsemblMetazoa:LLOJ006698-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; AJWK01022089; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJWK01022090; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GITU01007033; MBC1175736.1; -; Transcribed_RNA.
DR EnsemblMetazoa; LLOJ006698-RA; LLOJ006698-PA; LLOJ006698.
DR VEuPathDB; VectorBase:LLOJ006698; -.
DR OrthoDB; 3681901at2759; -.
DR Proteomes; UP000092461; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0044233; C:mitochondria-associated endoplasmic reticulum membrane; IEA:InterPro.
DR GO; GO:0005739; C:mitochondrion; IEA:GOC.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0051560; P:mitochondrial calcium ion homeostasis; IEA:InterPro.
DR GO; GO:1990456; P:mitochondrion-endoplasmic reticulum membrane tethering; IEA:InterPro.
DR CDD; cd20825; C1_PDZD8; 2.
DR CDD; cd00987; PDZ_serine_protease; 1.
DR CDD; cd21674; SMP_PDZD8; 1.
DR Gene3D; 2.30.42.10; -; 2.
DR Gene3D; 3.30.60.20; -; 2.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR039275; PDZD8.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR031468; SMP_LBD.
DR PANTHER; PTHR21519; PDZ DOMAIN-CONTAINING PROTEIN 8; 1.
DR PANTHER; PTHR21519:SF1; PDZ DOMAIN-CONTAINING PROTEIN 8; 1.
DR Pfam; PF13180; PDZ_2; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR SMART; SM00109; C1; 2.
DR SMART; SM00228; PDZ; 2.
DR SUPFAM; SSF57889; Cysteine-rich domain; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 2.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS51847; SMP; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 2.
DR PROSITE; PS50081; ZF_DAG_PE_2; 2.
PE 4: Predicted;
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00023055};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT TRANSMEM 7..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 63..257
FT /note="SMP-LTD"
FT /evidence="ECO:0000259|PROSITE:PS51847"
FT DOMAIN 323..380
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 649..699
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 1097..1147
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT REGION 441..496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 612..650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 909..964
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1062..1098
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1346..1374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 612..633
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 634..650
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1062..1081
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1082..1098
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1418 AA; 158395 MW; 806B3C29CF02F47F CRC64;
MDVVDILLFC FISCVIGAVL MLLGQYYVFV RFIETPNETE ESTSITQKFE LPDSVLSSIK
SSESESKNPI VAINLVLQFL FYELRHSNRV RKWFYRKLSL ELDELLTKST TGRLFDKLTI
RELELGGQFP DIKSLRVNNV ELHDAEGYIE NLDVMLDLSY RGNFRLSIDA DMVLGKKGFL
SVRVKHIAGL ARLQFTRKPY THWSLSFVGD PQVDLGIESQ FQGRQMQSNV TSFISNQIRK
AIRSKHTLPS YKLRYKPFFQ KIDDDLDASD TIPEGTLTVN ICEVSRLNVP TQITSIFCSL
TLASMPWAEA RQQDERTIIL SLDVEIHKAK NQQIGISFKQ IENAVMIDAI IPNTPAAKAN
LKKRDILISI EGKKVNHLTH VSKILKGINR PMFLLRIQRS AQGVIKNDAV QEEFEIIESI
DDGNISFSKA SDSVQIGTKI TRMNSLERNS SDSSVSNTPT NTPRKSGSSG NPLLRSKSRS
VSVENEPKSP SKIPNPEIFQ QQTTTECPFN SFMRMEQVCT FNLKENLVYL NLNVFGQTKD
ETIFLGYHNI FVPSILSECN ESTMGHYLKR FNLTAPEAPN LVTHPLSSQS GFESRLCYGD
VLISFAWSDF SASPASTSQP TDAKRGKYSG SRTGSTDKLE EDRSESQKQH NFIRTHFNRA
TQCDFCGKKI WLKDAAQCKE CSMCCHKKCI TKCQNSTVCG PVDAQVPISS PQQTVQPEFR
VTNHGFLSVR VKHIAGLARL QFTRKPYTHW SLSFVGDPQV DLGIESQFQG RQMQSNVTSF
ISNQIRKAIR SKHTLPSYKL RYKPFFQKID DDLDTSDTIP EGTLTVNICE QIENAVMIDA
IIPNTPAAKA NLKKRDILIS IEGKKVNHLT HVSKILKVQE EFEIIESIDD GNISFSKASD
SVQIGTKITR MNSLERNSSD SSVSNTPTNT PRKSGSSGNP LLRSKSRSVS VENEPKSPSK
IPNPEIFQQQ TTTECPFNSF MRMEQTKDET IFLGYHNIFV PSILSECNES TMGHYLKRFN
LTAPEAPNLV THPLSSQSGF ESRLCYGDVL ISFAWSDFNA SPAGTSQPTD TKRGKYSGSR
TGSTDKLEED RSESQKQHNF IRTHFNRATQ CDFCGKKIWL KDAAQCKECS MCCHKKCITK
CQNSTVCGPV DAQVPISSPQ QTVQPEFRVT QPCEEVNEGD DPEEINRLKS DGHRQSFSDL
LTQGLKRVNS ANNLAIPAIV SSLGQGSRSL PPSPQYTPRK QSLVQATNPL AQAIHRLEAA
SLTDIPGKQM SEKIDGIVEP FSGTPLDEIM TLAKTSSLQL YTELEPAKRV DKINEVLAKL
RLALDMETTT HADLSMASAE LRTAKLSKVE SPRVSSDANH GGKGSDARKA ASREKEAEAE
MARIAFLLGQ SEERVQALSV IMLHLCSALQ HAQSIASP
//