ID A0A1B0GJS0_LUTLO Unreviewed; 1061 AA.
AC A0A1B0GJS0;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Serine/threonine-protein kinase Warts {ECO:0008006|Google:ProtNLM};
OS Lutzomyia longipalpis (Sand fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Psychodoidea; Psychodidae;
OC Lutzomyia; Lutzomyia.
OX NCBI_TaxID=7200 {ECO:0000313|EnsemblMetazoa:LLOJ006713-PA, ECO:0000313|Proteomes:UP000092461};
RN [1] {ECO:0000313|Proteomes:UP000092461}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Jacobina {ECO:0000313|Proteomes:UP000092461};
RA Richards S., Qu C., Dillon R., Worley K., Scherer S., Batterton M.,
RA Taylor A., Hawes A., Hernandez B., Kovar C., Mandapat C., Pham C., Qu C.,
RA Jing C., Bess C., Bandaranaike D., Ngo D., Ongeri F., Arias F., Lara F.,
RA Weissenberger G., Kamau G., Han H., Shen H., Dinh H., Khalil I., Jones J.,
RA Shafer J., Jayaseelan J., Quiroz J., Blankenburg K., Nguyen L., Jackson L.,
RA Francisco L., Tang L.-Y., Pu L.-L., Perales L., Lorensuhewa L.,
RA Munidasa M., Coyle M., Taylor M., Puazo M., Firestine M., Scheel M.,
RA Javaid M., Wang M., Li M., Tabassum N., Saada N., Osuji N., Aqrawi P.,
RA Fu Q., Thornton R., Raj R., Goodspeed R., Mata R., Najjar R., Gubbala S.,
RA Lee S., Denson S., Patil S., Macmil S., Qi S., Matskevitch T.,
RA Palculict T., Mathew T., Vee V., Velamala V., Korchina V., Cai W., Liu W.,
RA Dai W., Zou X., Zhu Y., Zhang Y., Wu Y.-Q., Xin Y., Nazarath L., Kovar C.,
RA Han Y., Muzny D., Gibbs R.;
RT "Whole Genome Assembly of Lutzomyia longipalpis.";
RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:LLOJ006713-PA}
RP IDENTIFICATION.
RC STRAIN=Jacobina {ECO:0000313|EnsemblMetazoa:LLOJ006713-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; AJWK01022163; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJWK01022164; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJWK01022165; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJWK01022166; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJWK01022167; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A1B0GJS0; -.
DR EnsemblMetazoa; LLOJ006713-RA; LLOJ006713-PA; LLOJ006713.
DR VEuPathDB; VectorBase:LLOJ006713; -.
DR OrthoDB; 988261at2759; -.
DR Proteomes; UP000092461; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd21778; MobB_LATS1; 1.
DR CDD; cd05598; STKc_LATS; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR InterPro; IPR000961; AGC-kinase_C.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR049761; LATS1-like_MobB.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR24356; SERINE/THREONINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR24356:SF418; SERINE_THREONINE-PROTEIN KINASE WARTS; 1.
DR Pfam; PF00069; Pkinase; 2.
DR SMART; SM00133; S_TK_X; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51285; AGC_KINASE_CTER; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 673..972
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 973..1044
FT /note="AGC-kinase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51285"
FT REGION 101..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 151..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 232..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 428..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 988..1023
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 151..193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..219
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..258
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..292
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..315
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..358
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 455..489
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 502..543
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 703
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1061 AA; 116109 MW; 8A37D6EB958FAB77 CRC64;
MNSSGGKTPS SARLSEYTTN ALEQIRKDLC KFVHINNGSQ MTTDGSTTPQ LGQQQVTNHQ
NLAEREREIL MCQQLTNLIN AGYSEDQAVN ALKQASGRPD GLLFAATKPT SSPESPINGH
SAPPPSKLPA PLATKLMRKH SIERELSQAL QYNRNSPALD SGAGSSRSDS PHSHQQIIPS
RASTGQYSPS PCPSSFSDAP PLPPPRCSST PPTPPPVPVT NFQQLFKRMS PATNPTARSV
PLPSQSPARG TSPVSAVGTH PRQPMIVQNG PQAQQQLSQQ MQALSLYQSG GNSGEPPPPY
PIISAGAPPP PPSYTASIQS RQSPTQSSTT TDYRKSPSSG IYSATSAGSP SPITVSQAAV
TPPHPAAMAR PIPLPAWGAR QTKTQPPIIM QSVKSTQVQK PVLQTAIAPA APTTPCIATT
VAPPSYASSI HQKSQATTPS PVPTSKPPVS APSTPPAVVN GNVTPQPVVP TTEPPSYAST
MQALLAGQQS RNMPPPPPYT NSNATNARTT NGNSPGESPT SLKNGNLTTT PPLPPTASSS
VAKVNGIEKK GGAAPTAGTA STRGAGESGP CKKIKHHSPI PVRKNVSKEK EAERKEFRIR
HYSPQAFKFF MEQHIENVLK SYKARLYRRN QLEREMLKMG LTTQSQTQMR KMLCQKESNY
IRLKRAKMDK SMFLKIKDIG VGAFGEVSLV RKIDATNHLY AMKTLRKADV LKRNQVAHVK
AERDILAEAD NDWVVKLYYS FQDEDNLYFV MDYIPGGDLM SLLIKKEIFE EPLARFYIAE
LTCAVESVHK MGFIHRDIKP DNILIDRDGH IKLTDFGLCT GFRWTHDSKY YQKNGEHARQ
DSMEPWDDNG EVTRPSVLER RQRAHQRGLA HSLVGTPNYI APEVLERSGY TQLCDWWSVG
VILYEMLVGQ PPFLANTPGE TQHKVINWET TLHIPPQAKL SRESADMILK LCSSPDRRLG
KNADEVKAHP FFKSIDFSKN LREQPAPYIP KIEHPTDTSN FDPVDPGKLR NSSLDSGRSD
EFSDTGKPFH GFFEFTFRRF FDDNNTKIAV DGNDDLGPVY V
//
