ID   A0A1B0GNJ7_PHLPP        Unreviewed;       602 AA.
AC   A0A1B0GNJ7;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE            EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
OS   Phlebotomus papatasi (Sandfly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Psychodoidea; Psychodidae;
OC   Phlebotomus; Phlebotomus.
OX   NCBI_TaxID=29031 {ECO:0000313|EnsemblMetazoa:PPAI004872-PA, ECO:0000313|Proteomes:UP000092462};
RN   [1] {ECO:0000313|Proteomes:UP000092462}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Israel {ECO:0000313|Proteomes:UP000092462};
RA   Fulton L., Warren W., Minx P., Wilson R., Clifton S., Abrudan J.,
RA   Ramalho-Ortigao M., Lawyer P., Kamhawi S., Rowton E., Lehane M., Bates P.,
RA   Valenzeula J., Dillon R., Lobo N., Collins F., McDowell M.A.;
RT   "Phlebotomus papatasi, whole genome shotgun sequencing project.";
RL   Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:PPAI004872-PA}
RP   IDENTIFICATION.
RC   STRAIN=Israel {ECO:0000313|EnsemblMetazoa:PPAI004872-PA};
RG   EnsemblMetazoa;
RL   Submitted (AUG-2022) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC         Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR   EMBL; AJVK01029497; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AJVK01029498; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A1B0GNJ7; -.
DR   EnsemblMetazoa; PPAI004872-RA; PPAI004872-PA; PPAI004872.
DR   VEuPathDB; VectorBase:PPAI004872; -.
DR   OrthoDB; 5488182at2759; -.
DR   Proteomes; UP000092462; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR   CDD; cd17973; DEXHc_DHX15; 1.
DR   CDD; cd18791; SF2_C_RHA; 1.
DR   Gene3D; 1.20.120.1080; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR044756; DHX15_DEXHc.
DR   InterPro; IPR048333; HA2_WH.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR   PANTHER; PTHR18934:SF109; ATP-DEPENDENT RNA HELICASE DHX15 HOMOLOG; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF21010; HA2_C; 1.
DR   Pfam; PF04408; HA2_N; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
SQ   SEQUENCE   602 AA;  67946 MW;  B941BDAE63F74ED6 CRC64;
     MSKKRIEVTE MDPFIKKRRL EKGLEMEAAT SSAANSVAGL GQAAQNVVST SRNNTINTFT
     GTQYSQRYHA LYRKRITLPV FEYRADFMRL LAEHQTIVLV GETGSGKTTQ IPQWCVEYAQ
     SLGKKGVSCT QPRRVAAMSV AQRVSEEMDV VLGQEVGYSI RFEDCSSPRT ILKYMTDGML
     LREGMSDPML ETYQVILLDE AHERTLATDI LMGVLKEVIR QRSDLKLVVM SATLDAGKFQ
     QYFDNAPLMN VPGRTHPVEI FYTPEPERDY LEAAIRTVIQ IHMCEEIEGD VLMFLTGQEE
     IEEACKRIKR EVDNLGPEVG ELKCIPLYST LPPNLQQRIF EAAPPKKPNG AVGRKVVVST
     NIAETSLTID GVVFVIDPGF AKQKVYNPRI RVESLLVSPI SKASAQQRAG RAGRTRPGKC
     FRLYTEKAYK NEMQENTYPE ILRSNLGTVV LQLKKLGIDD LVHFDFMDPP APETLMRALE
     LLNYLAALDD DGNLTDLGAV MAEFPLDPQL AKMLIASCNH NCSNEILSIT AMLSGNEDPT
     WCYENFINYR SLKSADNVRQ QLSRIMDRFN LKRTSTEFTS KNYYVNIRKA LVQGFFMQVR
     NF
//