ID A0A1B0GRP7_MOUSE Unreviewed; 330 AA.
AC A0A1B0GRP7;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Pyridoxal phosphate binding protein {ECO:0000313|Ensembl:ENSMUSP00000147611.2};
DE Flags: Fragment;
GN Name=Plpbp {ECO:0000313|Ensembl:ENSMUSP00000147611.2,
GN ECO:0000313|MGI:MGI:1891207};
GN Synonyms=Prosc {ECO:0000313|MGI:MGI:1891207};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000147611.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0007829|PubMed:18034455}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18034455; DOI=10.1021/pr0701254;
RA Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
RT "Large-scale identification and evolution indexing of tyrosine
RT phosphorylation sites from murine brain.";
RL J. Proteome Res. 7:311-318(2008).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000147611.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000147611.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4] {ECO:0007829|PubMed:23806337}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT pathways.";
RL Mol. Cell 50:919-930(2013).
RN [5] {ECO:0000313|Ensembl:ENSMUSP00000147611.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000147611.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the pyridoxal phosphate-binding protein
CC YggS/PROSC family. {ECO:0000256|RuleBase:RU004514}.
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DR jPOST; A0A1B0GRP7; -.
DR ProteomicsDB; 320181; -.
DR Antibodypedia; 4465; 328 antibodies from 24 providers.
DR Ensembl; ENSMUST00000211393.2; ENSMUSP00000147611.2; ENSMUSG00000031485.16.
DR AGR; MGI:1891207; -.
DR MGI; MGI:1891207; Plpbp.
DR VEuPathDB; HostDB:ENSMUSG00000031485; -.
DR GeneTree; ENSGT00390000004928; -.
DR ChiTaRS; Prosc; mouse.
DR Proteomes; UP000000589; Chromosome 8.
DR Bgee; ENSMUSG00000031485; Expressed in gastrula and 260 other cell types or tissues.
DR ExpressionAtlas; A0A1B0GRP7; baseline and differential.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR CDD; cd06822; PLPDE_III_YBL036c_euk; 1.
DR Gene3D; 3.20.20.10; Alanine racemase; 1.
DR HAMAP; MF_02087; PLP_homeostasis; 1.
DR InterPro; IPR001608; Ala_racemase_N.
DR InterPro; IPR029066; PLP-binding_barrel.
DR InterPro; IPR011078; PyrdxlP_homeostasis.
DR NCBIfam; TIGR00044; YggS family pyridoxal phosphate-dependent enzyme; 1.
DR PANTHER; PTHR10146; PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN; 1.
DR PANTHER; PTHR10146:SF14; PYRIDOXAL PHOSPHATE HOMEOSTASIS PROTEIN; 1.
DR Pfam; PF01168; Ala_racemase_N; 1.
DR SUPFAM; SSF51419; PLP-binding barrel; 1.
DR PROSITE; PS01211; UPF0001; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:A0A1B0GRP7,
KW ECO:0007829|MaxQB:A0A1B0GRP7};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 37..230
FT /note="Alanine racemase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01168"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000147611.2"
SQ SEQUENCE 330 AA; 36173 MW; B3D6F0C7EC8A2305 CRC64;
XGGSMTAELG VGFALRAVNE RVQQSVARRP RDLPAIQPRL VAVSKTKPAD MVIEAYGHGQ
RTFGENYVQE LLEKASNPKI LSSCPEIKWH FIGHLQKQNV NKLMAVPNLS MLETVDSVKL
ADKVNSSWQK KGPTEPLKVM VQINTSGEDS KHGLLPSETI AVVEHIKASC PSLEFVGLMT
IGSFGHDLSQ GPNPDFQRLL TLRRELCEKL GIPVEQVELS MGMSMDFQHA TDCHKSDPAL
VRDTRAPNHL QLQLGCTLRS LWAARKRLST SYTAVPDTLS STFASFPQIE VGSTNVRIGS
TIFGERDYSK KPALDKTADA KASVPLVQGH
//
