ID A0A1B0GT94_MOUSE Unreviewed; 1148 AA.
AC A0A1B0GT94;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Sortilin-related VPS10 domain containing receptor 1 {ECO:0000313|Ensembl:ENSMUSP00000148254.2};
GN Name=Sorcs1 {ECO:0000313|Ensembl:ENSMUSP00000148254.2,
GN ECO:0000313|MGI:MGI:1929666};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000148254.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000148254.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000148254.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000148254.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000148254.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS
CC subfamily. {ECO:0000256|ARBA:ARBA00010818}.
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DR RefSeq; NP_001277285.1; NM_001290356.1.
DR AlphaFoldDB; A0A1B0GT94; -.
DR SMR; A0A1B0GT94; -.
DR ProteomicsDB; 312394; -.
DR Antibodypedia; 2334; 147 antibodies from 25 providers.
DR DNASU; 58178; -.
DR Ensembl; ENSMUST00000209783.2; ENSMUSP00000148254.2; ENSMUSG00000043531.17.
DR GeneID; 58178; -.
DR AGR; MGI:1929666; -.
DR CTD; 114815; -.
DR MGI; MGI:1929666; Sorcs1.
DR VEuPathDB; HostDB:ENSMUSG00000043531; -.
DR GeneTree; ENSGT01030000234563; -.
DR OrthoDB; 5840at2759; -.
DR BioGRID-ORCS; 58178; 0 hits in 39 CRISPR screens.
DR ChiTaRS; Sorcs1; mouse.
DR Proteomes; UP000000589; Chromosome 19.
DR Bgee; ENSMUSG00000043531; Expressed in ciliary body and 141 other cell types or tissues.
DR ExpressionAtlas; A0A1B0GT94; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.10.70.80; -; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 3.30.60.270; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF8; VPS10 DOMAIN-CONTAINING RECEPTOR SORCS1; 1.
DR Pfam; PF00801; PKD; 1.
DR Pfam; PF15902; Sortilin-Vps10; 1.
DR Pfam; PF15901; Sortilin_C; 1.
DR SMART; SM00602; VPS10; 1.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR SUPFAM; SSF49299; PKD domain; 2.
DR PROSITE; PS50093; PKD; 1.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|MaxQB:A0A1B0GT94,
KW ECO:0007829|PeptideAtlas:A0A1B0GT94};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..33
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 34..1148
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5008408599"
FT TRANSMEM 1102..1120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 836..880
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT REGION 38..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 98..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 107..133
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1148 AA; 128042 MW; F5C7B5755F0D0EB4 CRC64;
MGKVGAGDGS SAGLSALLAG AGLLMLLAPG VCSSLSCCPP QHPSSTPRRT LTPRGFPHPG
PLGRAPATPP PLFMRPLFAV APGDRALFLE RAGGSRVSVA TAARSGRRRR SGTEPEKIEP
GEGASRSRRD MLKDGGQQGL GTGARDPDKA TRFRMEELRL TSTTFALTGD SAHNQAMVHW
SGHNSSVILI LTKLYDYNLG SITESSLWRS TDYGTTYEKL NDKVGLKTIL SYLYVCPTNK
RKIMLLTDPE IESSLLISSD EGATYQKYRL NFYIQSLLFH PKQEDWILAY SQDQKLYSSA
EFGRRWQLIQ ESVVPNRFYW SVMGSSKEPD LVHLEARTVD GHSIYLTCRM QNCTEANRNK
PFPGYIDPDS LIVQDDYVFV QLTSGGRPHY YVSYRRSPFA QMKLPKYALP KDMHVISTDE
NQVFAAVQEW NQNDTYNLYI SDTRGVYFTL ALENVQSSRG PEGNVMIDLY EVAGIKGMFL
ANKKIDNQVK TFITYNKGRD WRLLQAPDAD LRGDPVHCLL PYCSLHLHLK VSENPYTSGI
IASRDTAPSI IVASGNIGSE LSDSDISMFV SSDAGNTWRQ IFEEEHSILY LDQGGVLVAM
KHTSLPIRHL WLSFDEGRSW SKYSFTSIPL FVDGVLGEPG EETLIMTVFG HFSHRSEWQL
VKVDYKSIFD RRCAEEDYRP WQLHSQGEAC IMGAKRIYKK RKSERKCMQG KYAGAMESEP
CVCTEADFDC DYGYERHSNG QCLPAFWFNP SSLSKDCSLG QSYLNSTGYR KVVSNNCTDG
VREQYTAKPQ KCPGKAPRGL RIVTADGKLT AEQGHNVTLM VQLEEGDVQR TLIQVDFGDG
IAVSYVNLSS MEDGIKHVYQ NVGIFRVTVQ VDNSLGSDSA VLYLHVTCPL EHVHLSLPFV
TTKNKEVNAT AVLWPSQVGT LTYVWWYGNN TEPLITLEGS ISFKFTSEGM NTITVQVSAG
NAILQDTKTI AVYEEFRSLR LAFSPNLDDY NPDIPEWRRD ISRVIKKSLV EATGIPSQHI
LVAVLPGLPT AAELFVLPYQ DGTRENKRSP EDLEQISEVL IHKLNQNLVH FELKPGVQVL
VHAAHLTAAP LVDLTPTHSG SAMLMLLSVV FVGLAVFVIY KFKRCVFLLL PSYPRPPPPS
SFCQVQKQ
//
