ID A0A1B0GV70_HUMAN Unreviewed; 593 AA.
AC A0A1B0GV70;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE SubName: Full=TEPSIN adaptor related protein complex 4 accessory protein {ECO:0000313|Ensembl:ENSP00000490393.1};
GN Name=TEPSIN {ECO:0000313|Ensembl:ENSP00000490393.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000490393.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000490393.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [2] {ECO:0007829|PubMed:18220336}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18220336; DOI=10.1021/pr0705441;
RA Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.D., Yates J.R.;
RT "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient
RT phosphoproteomic analysis.";
RL J. Proteome Res. 7:1346-1351(2008).
RN [3] {ECO:0007829|PubMed:18691976}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
RA Greff Z., Keri G., Stemmann O., Mann M.;
RT "Kinase-selective enrichment enables quantitative phosphoproteomics of the
RT kinome across the cell cycle.";
RL Mol. Cell 31:438-448(2008).
RN [4] {ECO:0007829|PubMed:20068231}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [5] {ECO:0007829|PubMed:23186163}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=23186163;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [6] {ECO:0000313|Ensembl:ENSP00000490393.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Vesicle {ECO:0000256|ARBA:ARBA00004373}.
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DR EMBL; AC027601; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005257124.1; XM_005257067.2.
DR AlphaFoldDB; A0A1B0GV70; -.
DR SMR; A0A1B0GV70; -.
DR MassIVE; A0A1B0GV70; -.
DR PeptideAtlas; A0A1B0GV70; -.
DR Antibodypedia; 53274; 15 antibodies from 7 providers.
DR Ensembl; ENST00000637944.2; ENSP00000490393.1; ENSG00000167302.11.
DR MANE-Select; ENST00000637944.2; ENSP00000490393.1; NM_001363764.2; NP_001350693.1.
DR HGNC; HGNC:26458; TEPSIN.
DR VEuPathDB; HostDB:ENSG00000167302; -.
DR GeneTree; ENSGT00390000015076; -.
DR OMA; LKDPSEC; -.
DR OrthoDB; 901080at2759; -.
DR BioGRID-ORCS; 146705; 113 hits in 1153 CRISPR screens.
DR ChiTaRS; TEPSIN; human.
DR GenomeRNAi; 146705; -.
DR Proteomes; UP000005640; Chromosome 17.
DR Bgee; ENSG00000167302; Expressed in granulocyte and 145 other cell types or tissues.
DR ExpressionAtlas; A0A1B0GV70; baseline and differential.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR CDD; cd03572; ENTH_like_Tepsin; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR InterPro; IPR013809; ENTH.
DR InterPro; IPR035802; ENTH/VHS_tepsin.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR039273; TEPSIN.
DR PANTHER; PTHR21514:SF0; AP-4 COMPLEX ACCESSORY SUBUNIT TEPSIN; 1.
DR PANTHER; PTHR21514; UNCHARACTERIZED; 1.
DR Pfam; PF01417; ENTH; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
PE 1: Evidence at protein level;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Proteomics identification {ECO:0007829|EPD:A0A1B0GV70,
KW ECO:0007829|MaxQB:A0A1B0GV70};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 24..131
FT /note="ENTH"
FT /evidence="ECO:0000259|Pfam:PF01417"
FT REGION 195..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 423..533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 555..593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..291
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 457..476
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 477..495
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..520
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 565..579
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 593 AA; 62042 MW; 283106E7EB1DA087 CRC64;
MAAAPPLRDR LSFLHRLPIL LKGTSDDDVP CPGYLFEEIA KISHESPGSS QCLLEYLLSR
LHSSSGHGKL KVLKILLYLC SHGSSFFLLI LKRNSAFIQE AAAFAGPPDP LHGNSLYQKV
RAAAQDLGST LFSDTVLPLA PSQPLGTPPA TGMGSQARPH STLQGFGYSK EHGRTGSAGE
AFLSTIQKAA EVVASAMRPG PESPSTRRLL PRGDTYQPAM MPSASHGPPT LGNLLPGAIP
GPRAVRHQPG QAGGGWDELD SGPSSQNSSQ NSDLSRVSDS GSHSGSDSHS GASREPGDLA
ERVEVVALSD CQQELSLVRT VTRGPRAFLS REEAQHFIKA CGLLNCEAVL QLLTCHLRGT
SECTQLRALC AIASLGSSDL LPQEHILLRT RPWLQELSMG SPGPVTNKAT KILRHFEASC
GQLSPARGTS AEPGPTAALP GPSDLLTDAV PLPGSQVFLQ PLSSTPVSSR SPAPSSGMPS
SPVPTPPPDA SPIPAPGDPS EAEARLAESR RWRPERIPGG TDSPKRGPSS CAWSRDSLFA
GMELVACPRL VGAGAAAGES CPDAPRAPQT SSQRTAAKEP PGSEPSAFAF LNA
//