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Database: UniProt
Entry: A0A1B0GV70_HUMAN
LinkDB: A0A1B0GV70_HUMAN
Original site: A0A1B0GV70_HUMAN 
ID   A0A1B0GV70_HUMAN        Unreviewed;       593 AA.
AC   A0A1B0GV70;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   24-JAN-2024, entry version 48.
DE   SubName: Full=TEPSIN adaptor related protein complex 4 accessory protein {ECO:0000313|Ensembl:ENSP00000490393.1};
GN   Name=TEPSIN {ECO:0000313|Ensembl:ENSP00000490393.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000490393.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000490393.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA   Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA   Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA   LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA   Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA   Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA   Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT   human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0007829|PubMed:18220336}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=18220336; DOI=10.1021/pr0705441;
RA   Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.D., Yates J.R.;
RT   "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient
RT   phosphoproteomic analysis.";
RL   J. Proteome Res. 7:1346-1351(2008).
RN   [3] {ECO:0007829|PubMed:18691976}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
RA   Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
RA   Greff Z., Keri G., Stemmann O., Mann M.;
RT   "Kinase-selective enrichment enables quantitative phosphoproteomics of the
RT   kinome across the cell cycle.";
RL   Mol. Cell 31:438-448(2008).
RN   [4] {ECO:0007829|PubMed:20068231}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA   Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA   Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT   "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT   site occupancy during mitosis.";
RL   Sci. Signal. 3:RA3-RA3(2010).
RN   [5] {ECO:0007829|PubMed:23186163}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=23186163;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [6] {ECO:0000313|Ensembl:ENSP00000490393.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Vesicle {ECO:0000256|ARBA:ARBA00004373}.
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DR   EMBL; AC027601; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005257124.1; XM_005257067.2.
DR   AlphaFoldDB; A0A1B0GV70; -.
DR   SMR; A0A1B0GV70; -.
DR   MassIVE; A0A1B0GV70; -.
DR   PeptideAtlas; A0A1B0GV70; -.
DR   Antibodypedia; 53274; 15 antibodies from 7 providers.
DR   Ensembl; ENST00000637944.2; ENSP00000490393.1; ENSG00000167302.11.
DR   MANE-Select; ENST00000637944.2; ENSP00000490393.1; NM_001363764.2; NP_001350693.1.
DR   HGNC; HGNC:26458; TEPSIN.
DR   VEuPathDB; HostDB:ENSG00000167302; -.
DR   GeneTree; ENSGT00390000015076; -.
DR   OMA; LKDPSEC; -.
DR   OrthoDB; 901080at2759; -.
DR   BioGRID-ORCS; 146705; 113 hits in 1153 CRISPR screens.
DR   ChiTaRS; TEPSIN; human.
DR   GenomeRNAi; 146705; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000167302; Expressed in granulocyte and 145 other cell types or tissues.
DR   ExpressionAtlas; A0A1B0GV70; baseline and differential.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR   CDD; cd03572; ENTH_like_Tepsin; 1.
DR   Gene3D; 1.25.40.90; -; 1.
DR   InterPro; IPR013809; ENTH.
DR   InterPro; IPR035802; ENTH/VHS_tepsin.
DR   InterPro; IPR008942; ENTH_VHS.
DR   InterPro; IPR039273; TEPSIN.
DR   PANTHER; PTHR21514:SF0; AP-4 COMPLEX ACCESSORY SUBUNIT TEPSIN; 1.
DR   PANTHER; PTHR21514; UNCHARACTERIZED; 1.
DR   Pfam; PF01417; ENTH; 1.
DR   SUPFAM; SSF48464; ENTH/VHS domain; 1.
PE   1: Evidence at protein level;
KW   Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW   Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW   Proteomics identification {ECO:0007829|EPD:A0A1B0GV70,
KW   ECO:0007829|MaxQB:A0A1B0GV70};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT   DOMAIN          24..131
FT                   /note="ENTH"
FT                   /evidence="ECO:0000259|Pfam:PF01417"
FT   REGION          195..297
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          423..533
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          555..593
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        260..291
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        457..476
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        477..495
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        503..520
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        565..579
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   593 AA;  62042 MW;  283106E7EB1DA087 CRC64;
     MAAAPPLRDR LSFLHRLPIL LKGTSDDDVP CPGYLFEEIA KISHESPGSS QCLLEYLLSR
     LHSSSGHGKL KVLKILLYLC SHGSSFFLLI LKRNSAFIQE AAAFAGPPDP LHGNSLYQKV
     RAAAQDLGST LFSDTVLPLA PSQPLGTPPA TGMGSQARPH STLQGFGYSK EHGRTGSAGE
     AFLSTIQKAA EVVASAMRPG PESPSTRRLL PRGDTYQPAM MPSASHGPPT LGNLLPGAIP
     GPRAVRHQPG QAGGGWDELD SGPSSQNSSQ NSDLSRVSDS GSHSGSDSHS GASREPGDLA
     ERVEVVALSD CQQELSLVRT VTRGPRAFLS REEAQHFIKA CGLLNCEAVL QLLTCHLRGT
     SECTQLRALC AIASLGSSDL LPQEHILLRT RPWLQELSMG SPGPVTNKAT KILRHFEASC
     GQLSPARGTS AEPGPTAALP GPSDLLTDAV PLPGSQVFLQ PLSSTPVSSR SPAPSSGMPS
     SPVPTPPPDA SPIPAPGDPS EAEARLAESR RWRPERIPGG TDSPKRGPSS CAWSRDSLFA
     GMELVACPRL VGAGAAAGES CPDAPRAPQT SSQRTAAKEP PGSEPSAFAF LNA
//
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