ID A0A1B0GXH8_MOUSE Unreviewed; 306 AA.
AC A0A1B0GXH8;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=ELK4, member of ETS oncogene family {ECO:0000313|Ensembl:ENSMUSP00000118880.2};
DE Flags: Fragment;
GN Name=Elk4 {ECO:0000313|Ensembl:ENSMUSP00000118880.2,
GN ECO:0000313|MGI:MGI:102853};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000118880.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000118880.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000118880.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000118880.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000118880.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004019}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|ARBA:ARBA00005562,
CC ECO:0000256|RuleBase:RU004019}.
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DR AlphaFoldDB; A0A1B0GXH8; -.
DR SMR; A0A1B0GXH8; -.
DR ProteomicsDB; 371746; -.
DR Antibodypedia; 20682; 160 antibodies from 26 providers.
DR Ensembl; ENSMUST00000146432.2; ENSMUSP00000118880.2; ENSMUSG00000026436.16.
DR AGR; MGI:102853; -.
DR MGI; MGI:102853; Elk4.
DR VEuPathDB; HostDB:ENSMUSG00000026436; -.
DR GeneTree; ENSGT00940000158900; -.
DR OMA; GDPEMPG; -.
DR ChiTaRS; Elk4; mouse.
DR Proteomes; UP000000589; Chromosome 1.
DR Bgee; ENSMUSG00000026436; Expressed in saccule of membranous labyrinth and 256 other cell types or tissues.
DR ExpressionAtlas; A0A1B0GXH8; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; ETS; 1.
DR PANTHER; PTHR11849:SF21; ETS DOMAIN-CONTAINING PROTEIN ELK-4; 1.
DR Pfam; PF00178; Ets; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
PE 1: Evidence at protein level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004019};
KW Nucleus {ECO:0000256|RuleBase:RU004019};
KW Proteomics identification {ECO:0007829|EPD:A0A1B0GXH8,
KW ECO:0007829|ProteomicsDB:A0A1B0GXH8};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 5..85
FT /note="ETS"
FT /evidence="ECO:0000259|PROSITE:PS50061"
FT REGION 116..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 245..306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 250..271
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 306
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000118880.2"
SQ SEQUENCE 306 AA; 33887 MW; 85771110347E3FA1 CRC64;
MDSAITLWQF LLQLLQEPQN EHMICWTSNN GEFKLLQAEE VARLWGIRKN KPNMNYDKLS
RALRYYYVKN IIKKVNGQKF VYKFVSYPEI LKMDPLTVGR IEGDCEALNS IETSSSKDVE
YGGKERPPQP GAKTSSRNDY IHSGLYSSFT LNSLNTSNKK LFKSIKIENP AEKLAEKKAQ
EPTPSVIKFV TTPAKKPPIE PVAAAFATSP SLSPSSEETI QALETLVSPT LPSLETPASI
SILATTFNPT PPVPSTPLPL KEPPRTPSPP LSSNPDIDTD IESVASQPME LPENLSLEPK
NEDSAL
//
