ID A0A1B0VLN9_FERIS Unreviewed; 865 AA.
AC A0A1B0VLN9;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2023, sequence version 2.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Cadmium-translocating P-type ATPase {ECO:0000313|EMBL:AMW33644.2};
GN Name=cadA {ECO:0000313|EMBL:AMW33644.2};
GN ORFNames=NA23_01330 {ECO:0000313|EMBL:AMW33644.2};
OS Fervidobacterium islandicum.
OC Bacteria; Thermotogota; Thermotogae; Thermotogales; Fervidobacteriaceae;
OC Fervidobacterium.
OX NCBI_TaxID=2423 {ECO:0000313|EMBL:AMW33644.2, ECO:0000313|Proteomes:UP000093740};
RN [1] {ECO:0000313|EMBL:AMW33644.2, ECO:0000313|Proteomes:UP000093740}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AW-1 {ECO:0000313|EMBL:AMW33644.2,
RC ECO:0000313|Proteomes:UP000093740};
RX PubMed=26421103; DOI=10.1186/s40793-015-0063-4;
RA Lee Y.J., Jeong H., Park G.S., Kwak Y., Lee S.J., Lee S.J., Park M.K.,
RA Kim J.Y., Kang H.K., Shin J.H., Lee D.W.;
RT "Genome sequence of a native-feather degrading extremely thermophilic
RT Eubacterium, Fervidobacterium islandicum AW-1.";
RL Stand. Genomic Sci. 10:71-71(2015).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362081}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type IB subfamily. {ECO:0000256|ARBA:ARBA00006024,
CC ECO:0000256|RuleBase:RU362081}.
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DR EMBL; CP014334; AMW33644.2; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B0VLN9; -.
DR STRING; 2423.NA23_01330; -.
DR KEGG; fia:NA23_01330; -.
DR eggNOG; COG2217; Bacteria.
DR Proteomes; UP000093740; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0019829; F:ATPase-coupled monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00371; HMA; 3.
DR CDD; cd07548; P-type_ATPase-Cd_Zn_Co_like; 1.
DR Gene3D; 3.30.70.100; -; 3.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR017969; Heavy-metal-associated_CS.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR036163; HMA_dom_sf.
DR InterPro; IPR027256; P-typ_ATPase_IB.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01512; ATPase-IB2_Cd; 1.
DR NCBIfam; TIGR01525; ATPase-IB_hvy; 1.
DR NCBIfam; TIGR01494; ATPase_P-type; 1.
DR PANTHER; PTHR48085; CADMIUM/ZINC-TRANSPORTING ATPASE HMA2-RELATED; 1.
DR PANTHER; PTHR48085:SF5; CADMIUM_ZINC-TRANSPORTING ATPASE HMA2; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF00403; HMA; 3.
DR Pfam; PF00702; Hydrolase; 1.
DR PRINTS; PR00119; CATATPASE.
DR PRINTS; PR00941; CDATPASE.
DR SFLD; SFLDG00002; C1.7:_P-type_atpase_like; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF55008; HMA, heavy metal-associated domain; 3.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
DR PROSITE; PS01047; HMA_1; 1.
DR PROSITE; PS50846; HMA_2; 3.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU362081};
KW Cell membrane {ECO:0000256|RuleBase:RU362081};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362081};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU362081};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU362081};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362081};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362081}.
FT TRANSMEM 280..296
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 480..500
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 512..533
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 817..836
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT DOMAIN 2..70
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 80..149
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 159..228
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
SQ SEQUENCE 865 AA; 93425 MW; 8C74FA3FF12B54B8 CRC64;
MLKKEVILEG LDCANCAAKI EEEVNKLNGV KAYMNFMNKT LTLEIESEQE YKNILQQVKT
IVHKHEPDVV VKEKSVNKSN KKVLILEGLD CANCAAKIEA QTQSLEGVNS ATVDFVSKKL
TIEAVDKKEF GKILGEVTSI VNKLEPDVKI VDAEKKKVNK SIVMLEGLGC ANCAAKIEKE
ISGLEGVEFA AVDFVSKKLT LEISPKVNRS ELNEKIEGIV KKIEPDVKVI FEENTSKANV
KENNEEEEEG VNKKEIIRLV VGGAIFAVGI IFNFQNWLEL TLFIISYIIV GGEVVLRAIK
GIARGQVFSE HFLMSIATIG AFFVGEYPEG VAVMLFYLVG ELLQNIAVGH SRKSISALMD
IRPDYANLKV GDEIRKVSPE EVNIGDIIIV KPGEKVPLDG KVIEGNSMVD TAALTGESVP
REVGPGDDVL SGFINKNGVL TIEVTKDYGD STVSKILDLV QNASSRKAPT EKFITKFARF
YTPIVVFGAL ALAIIPPLVI PGATFSTWIY RALVFLVISC PCALVVSIPL GFFGGIGGAA
KRGILVKGSN YLDALNNVET VVFDKTGTLT KGVFEVVSIN PQSDFTKEEL IEYAAYAESH
SSHPIALSIL KAYNKDVDIT KIEDYEEIAG HGIRAKVGGK EILVGNSKLM NKENIKYQEV
ETLGTVVHVA VDKKYAGNIV ISDAVKEDSA DAIKGLKALG VRNIVMLTGD SKAVGEKIAT
QLGIDEVYTE LLPADKVEKI EALDAKKSHK GKIVFVGDGI NDAPVLARAD IGVAMGGLGS
DAAIEAADIV IMTDEPSKIV TAIKIAKRTR KIVMQNIVFA LGVKAIFLAL GAVGVATMWE
AVFADTGVAI IAILNAMRVM NTKSI
//
