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Database: UniProt
Entry: A0A1B0VNH4_FERIS
LinkDB: A0A1B0VNH4_FERIS
Original site: A0A1B0VNH4_FERIS 
ID   A0A1B0VNH4_FERIS        Unreviewed;       444 AA.
AC   A0A1B0VNH4;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   16-JAN-2019, entry version 19.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=NA23_00005 {ECO:0000313|EMBL:AMW33602.1};
OS   Fervidobacterium islandicum.
OC   Bacteria; Thermotogae; Thermotogales; Fervidobacteriaceae;
OC   Fervidobacterium.
OX   NCBI_TaxID=2423 {ECO:0000313|EMBL:AMW33602.1, ECO:0000313|Proteomes:UP000093740};
RN   [1] {ECO:0000313|EMBL:AMW33602.1, ECO:0000313|Proteomes:UP000093740}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AW-1 {ECO:0000313|EMBL:AMW33602.1,
RC   ECO:0000313|Proteomes:UP000093740};
RX   PubMed=26421103; DOI=10.1186/s40793-015-0063-4;
RA   Lee Y.J., Jeong H., Park G.S., Kwak Y., Lee S.J., Lee S.J., Park M.K.,
RA   Kim J.Y., Kang H.K., Shin J.H., Lee D.W.;
RT   "Genome sequence of a native-feather degrading extremely thermophilic
RT   Eubacterium, Fervidobacterium islandicum AW-1.";
RL   Stand. Genomic Sci. 10:71-71(2015).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS01082709}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP014334; AMW33602.1; -; Genomic_DNA.
DR   EnsemblBacteria; AMW33602; AMW33602; NA23_00005.
DR   KEGG; fia:NA23_00005; -.
DR   KO; K02313; -.
DR   Proteomes; UP000093740; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756129};
KW   Complete proteome {ECO:0000313|Proteomes:UP000093740};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS01082702};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00756116};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01082706};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756117}.
FT   DOMAIN      135    267       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      346    414       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     143    150       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   444 AA;  50873 MW;  4BA8A9F5EBA48C39 CRC64;
     MKEKIMSALK EKVSRQQWEH WFIDFYVKRV EGTHVVFEVG NLFLKGYIEK KFDKVIKKAI
     AEAVSQGATY EIVYAQIVNP ENFEDEVPEN VALVRKKPVL ITPLNPKYRF DNFVVDEFNQ
     FAYNLLLEAA KKPGTYNPIF IYSEAGMGKT HLVQAYGNYL LSQNPDLRFA YLTSESFMNE
     LITKLKSGNM EEFRERYRKK IDVLVIDDIQ FLAGKKGVQI ELFHTFNTLY EAGKQIIVCS
     DRSPKELKDF QDRVISRFQM GVVAQIKTPS QEAMYKIAKK VVDDEKADID DGILRYVAAH
     IRGSIRILKG AVIKLIAYKS MYGELNISIV KSILRDVLTE DTSTSSEGDI VDVIAKTFKT
     TKDDILSGSR DRNTSLARQV CMYFMVKKYG LSTRKVGEIF NKTHPSVINS VKSIEKKLEN
     EKDFALLLRS IEKELQKSVG KAYS
//
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