ID A0A1B0VR40_FERIS Unreviewed; 671 AA.
AC A0A1B0VR40;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Flagellar biosynthesis protein FlhA {ECO:0000256|RuleBase:RU364093};
GN Name=flhA {ECO:0000256|RuleBase:RU364093,
GN ECO:0000313|EMBL:AMW33630.1};
GN ORFNames=NA23_00980 {ECO:0000313|EMBL:AMW33630.1};
OS Fervidobacterium islandicum.
OC Bacteria; Thermotogota; Thermotogae; Thermotogales; Fervidobacteriaceae;
OC Fervidobacterium.
OX NCBI_TaxID=2423 {ECO:0000313|EMBL:AMW33630.1, ECO:0000313|Proteomes:UP000093740};
RN [1] {ECO:0000313|EMBL:AMW33630.1, ECO:0000313|Proteomes:UP000093740}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AW-1 {ECO:0000313|EMBL:AMW33630.1,
RC ECO:0000313|Proteomes:UP000093740};
RX PubMed=26421103; DOI=10.1186/s40793-015-0063-4;
RA Lee Y.J., Jeong H., Park G.S., Kwak Y., Lee S.J., Lee S.J., Park M.K.,
RA Kim J.Y., Kang H.K., Shin J.H., Lee D.W.;
RT "Genome sequence of a native-feather degrading extremely thermophilic
RT Eubacterium, Fervidobacterium islandicum AW-1.";
RL Stand. Genomic Sci. 10:71-71(2015).
CC -!- FUNCTION: Required for formation of the rod structure of the flagellar
CC apparatus. Together with FliI and FliH, may constitute the export
CC apparatus of flagellin. {ECO:0000256|RuleBase:RU364093}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU364093};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU364093}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FHIPEP (flagella/HR/invasion proteins export
CC pore) family. {ECO:0000256|ARBA:ARBA00008835,
CC ECO:0000256|RuleBase:RU364093}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU364093}.
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DR EMBL; CP014334; AMW33630.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B0VR40; -.
DR STRING; 2423.NA23_00980; -.
DR KEGG; fia:NA23_00980; -.
DR eggNOG; COG1298; Bacteria.
DR Proteomes; UP000093740; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044780; P:bacterial-type flagellum assembly; IEA:InterPro.
DR GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR Gene3D; 3.40.30.60; FHIPEP family, domain 1; 1.
DR Gene3D; 1.10.8.540; FHIPEP family, domain 3; 1.
DR Gene3D; 3.40.50.12790; FHIPEP family, domain 4; 1.
DR InterPro; IPR042194; FHIPEP_1.
DR InterPro; IPR042193; FHIPEP_3.
DR InterPro; IPR042196; FHIPEP_4.
DR InterPro; IPR006301; FlhA.
DR InterPro; IPR001712; T3SS_FHIPEP.
DR NCBIfam; TIGR01398; FlhA; 1.
DR PANTHER; PTHR30161:SF1; FLAGELLAR BIOSYNTHESIS PROTEIN FLHA-RELATED; 1.
DR PANTHER; PTHR30161; FLAGELLAR EXPORT PROTEIN, MEMBRANE FLHA SUBUNIT-RELATED; 1.
DR Pfam; PF00771; FHIPEP; 1.
DR PIRSF; PIRSF005419; FlhA; 1.
DR PRINTS; PR00949; TYPE3IMAPROT.
PE 3: Inferred from homology;
KW Bacterial flagellum biogenesis {ECO:0000256|RuleBase:RU364093};
KW Bacterial flagellum protein export {ECO:0000256|RuleBase:RU364093};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU364093};
KW Cell projection {ECO:0000313|EMBL:AMW33630.1};
KW Cilium {ECO:0000313|EMBL:AMW33630.1};
KW Flagellum {ECO:0000313|EMBL:AMW33630.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU364093};
KW Protein transport {ECO:0000256|RuleBase:RU364093};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU364093};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU364093}; Transport {ECO:0000256|RuleBase:RU364093}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 83..104
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 172..194
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 254..284
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
SQ SEQUENCE 671 AA; 73751 MW; 3274C8CC81E00FB5 CRC64;
MIIPIPDFLL DFFQLLNISI SLVILFSTMY ITHALELASF PTMLLIVTIF RLALNVASTR
AILLEGPKFG GKVIQTFGNF VVGGNYVVGI VVFLILVIIQ FIVITRGSER IAEVAARFTL
DAMPGKQMSV DADLNAGLIT EDEARRRREE IRREADFYGA MDGASKFVRG DAIASIIITL
VNSIGGIIIG VLMHRLGFAD AAKTFLLYTV GDGLVSQIPA LMVSTATGII VSRSATKDNL
GTELIRELSG EKKVIILTGV VIILLGLFTP LPTFTSLLIG GLFLTVGIMI KEEARPEVQP
GIAGVPGVGG APPGAAGVPA GPVLSTPEEV AEVLQSDTVE INIGYGLLPL ADLSQGGDML
ERLTMIRRQL AQELGLVLSP IRVRDSVLLK PNEYAIFIRG AEVARYELFP NRLLAINPGF
VTERIAGIEV KEPAFGLQAF WIDESKRDEA IQKGFTVVDP PTVFATHVTE ILRRYAPELL
GNREFQLLVD GLRSKFDRLV DEVFNVVKPT VVKKVLQELL REGVSIRNLP FIFELILDNA
ERARDVESLV EYVRRGLKRQ IASKLLSQDK QIHAVALDSE LERMLTESIS ESDEGRYLSV
NPQIMREVIE RISQELEKLM RKGYSPILIV SGTIRPYLAK MVLRFIPGVT VIAFEEVPED
VNLSIEGVVR I
//
