ID A0A1B0XWG6_9CAUD Unreviewed; 887 AA.
AC A0A1B0XWG6;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=PC14_00160 {ECO:0000313|EMBL:ANH51450.1};
OS Campylobacter phage PC14.
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Eucampyvirinae; Fletchervirus; Fletchervirus NCTC12673.
OX NCBI_TaxID=1541686 {ECO:0000313|EMBL:ANH51450.1, ECO:0000313|Proteomes:UP000202854};
RN [1] {ECO:0000313|EMBL:ANH51450.1, ECO:0000313|Proteomes:UP000202854}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PC14 {ECO:0000313|EMBL:ANH51450.1,
RC ECO:0000313|Proteomes:UP000202854};
RA Janez N., Peterka M., Accetto T.;
RT "Campylobacter bacteriophages isolated in Slovenia.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755}.
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DR EMBL; KX236333; ANH51450.1; -; Genomic_DNA.
DR RefSeq; YP_009321758.1; NC_031909.1.
DR GeneID; 30307095; -.
DR KEGG; vg:30307095; -.
DR OrthoDB; 165at10239; -.
DR Proteomes; UP000202854; Genome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1280.300; -; 1.
DR Gene3D; 3.30.342.10; DNA Polymerase, chain B, domain 1; 1.
DR Gene3D; 3.40.1820.10; DnaQ-like 3'-5' exonuclease; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10322; DNA POLYMERASE CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR10322:SF23; DNA POLYMERASE DELTA CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR Pfam; PF03104; DNA_pol_B_exo1; 1.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral DNA replication {ECO:0000256|ARBA:ARBA00023109}.
FT DOMAIN 98..270
FT /note="DNA-directed DNA polymerase family B exonuclease"
FT /evidence="ECO:0000259|Pfam:PF03104"
FT DOMAIN 344..764
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
SQ SEQUENCE 887 AA; 103904 MW; 9BB077506958ABB2 CRC64;
MFKYEYVFEH NFKLYARLYD EVTKNSIIKE YKSTEYVPEL FIRTNEKTEY KDFYTHGYLK
KKTFKATYEI YQYLKNVSPS TPLYGNINRP QKYIRENFKD IDCNHEFRTQ YLDIETRAIN
GYAKPSNPTE EISLIQVYDN YLNKFIIFGT KDLNIDLQSD IGEVIYKKCD NEIQMLKKYL
TFVVKTNPTI IAGFNSNLFD IPYIVNRMIH LGIDDYVELS PIKAITHKRM KTNDDIEYDG
VKIEGIIQLD LRDLYIKYTT QKPSRFSLDE ISKLELGDTK VNYDGSIEDL YKDFNKFVSY
GLKDVELLIK LERKLKLLKV CQLVAYKCGV NADEVSGTLM QWASLMYNYA LSQNVILPLR
QLKIINYDPP YPGGWVRVIE GLHKNVCSYD FTSLYPNIII EFKIGLDNYI PVSSIPYEKA
KMLEENRARF MNEAPNEVIS TSLPEDLKDM LNKYFYFYSE TYDKTNNDSM EEFYYFKNII
DNKDHIRYIC KKYGVNVTPN GCLYFSDGTS LFSELIENFF KDRLKHKDFL KNDNLTASEI
DYHDLMQYMF KILMNSAYGS TSLAINPFSF GKKMSESITT TGRFLNMWVS YRVNKFCNET
YNLNIDVNSR PLSIQCDTDS NYFEFKFLET PKDLQENAKF LKSYCETTIS PVIDDAISEA
VTAINGLDKN SNLGMEQETI CDRLISCARK RYVGRYFNKK KSNRGFKITG LPMIDKTTPK
WTKLKLNECL DLILDSDLHG LRQFINHIKD EFKQQLLSDI CMNKSVSSLS YVVSNDKWVS
SINGNPCPIQ SRGSIHYNNL TNKYKLKKIM EGEKVYIVYL KTPNTITGDN VICIPDDEIV
REIPSISEFV DYETMFEKYF IQKLDIMSKH IGFDYKNIFA NTLDEWL
//
