ID A0A1B0ZSX2_9RHOB Unreviewed; 415 AA.
AC A0A1B0ZSX2;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=RNA methyltransferase {ECO:0000313|EMBL:ANP37210.1};
GN Name=rumA {ECO:0000313|EMBL:ANP37210.1};
GN ORFNames=JL2886_02321 {ECO:0000313|EMBL:ANP37210.1};
OS Phaeobacter gallaeciensis.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Phaeobacter.
OX NCBI_TaxID=60890 {ECO:0000313|EMBL:ANP37210.1, ECO:0000313|Proteomes:UP000092565};
RN [1] {ECO:0000313|EMBL:ANP37210.1, ECO:0000313|Proteomes:UP000092565}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JL2886 {ECO:0000313|EMBL:ANP37210.1,
RC ECO:0000313|Proteomes:UP000092565};
RA Evans L.H., Alamgir A., Owens N., Weber N.D., Virtaneva K., Barbian K.,
RA Babar A., Rosenke K.;
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. RNA M5U methyltransferase family. {ECO:0000256|PROSITE-
CC ProRule:PRU01024}.
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DR EMBL; CP015124; ANP37210.1; -; Genomic_DNA.
DR RefSeq; WP_065272063.1; NZ_JARCJB010000018.1.
DR AlphaFoldDB; A0A1B0ZSX2; -.
DR PATRIC; fig|60890.4.peg.2249; -.
DR OrthoDB; 9804590at2; -.
DR Proteomes; UP000092565; Chromosome.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 2.40.50.1070; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR030390; MeTrfase_TrmA_AS.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR010280; U5_MeTrfase_fam.
DR PANTHER; PTHR11061; RNA M5U METHYLTRANSFERASE; 1.
DR PANTHER; PTHR11061:SF30; TRNA (URACIL(54)-C(5))-METHYLTRANSFERASE; 1.
DR Pfam; PF05958; tRNA_U5-meth_tr; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51687; SAM_MT_RNA_M5U; 1.
DR PROSITE; PS01230; TRMA_1; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01024}; Reference proteome {ECO:0000313|Proteomes:UP000092565};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01024};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01024}.
FT ACT_SITE 371
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10015"
FT ACT_SITE 371
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
FT BINDING 246
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
FT BINDING 273
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
FT BINDING 293
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
FT BINDING 345
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024"
SQ SEQUENCE 415 AA; 44556 MW; 3081EB75A0B17739 CRC64;
MTDAARTTAT ITRLGQQGDG VAEGPLFAPR TLPGEVVSGI VSGSQLTEVR IETPSETRVQ
APCRHYKSCG GCQLQHASDA FVADWKVEVV KTALRAQGLE TEFRPIHTSP SRSRRRATLT
VRRTKKGAMA GFHGRASDVI TPIPDCQLLD PALIRAIPLA EELAMAGASR KAPLSVTLTT
SEVGLDVMVR EGKPLDGSLR LELARIAGQN GVARLTWGDE QVLMEQPPVQ AFGPARVCPP
PGSFLQATKD GEAALLSAVQ EITKGAKRLV DLFAGCGTFA LPLAQDAEVH AVEGERDMIA
ALDAGWRRAQ GLKKVTSEVR DLFRNPLLPE DLNPFGAHFD AAVIDPPRAG GEAQIAQLAQ
ARTPVIAYVS CYPVTFARDA KTLVVAGYRL NWVQVVDQFR WSAHTELAAS FTLDS
//
