UniProt: A0A1B1AY54

Database: UniProt
Entry: A0A1B1AY54_9ACTN

LinkDB:  A0A1B1AY54_9ACTN 
Original site:  A0A1B1AY54_9ACTN

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Ontology (5)   
   GO (5)   
Gene (1)   
   KEGG GENES (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (33)   
   InterPro (17)   
   Pfam (7)   
   PROSITE (4)   
   SMART (5)   
All databases (41)   

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ID   A0A1B1AY54_9ACTN        Unreviewed;      2272 AA.
AC   A0A1B1AY54;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   RecName: Full=Polyketide synthase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=AVL59_19490 {ECO:0000313|EMBL:ANP51499.1};
OS   Streptomyces griseochromogenes.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=68214 {ECO:0000313|EMBL:ANP51499.1, ECO:0000313|Proteomes:UP000092659};
RN   [1] {ECO:0000313|EMBL:ANP51499.1, ECO:0000313|Proteomes:UP000092659}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 14511 {ECO:0000313|EMBL:ANP51499.1,
RC   ECO:0000313|Proteomes:UP000092659};
RA   Wu L.;
RT   "Complete genome sequence of Streptomyces griseochromogenes ATCC 14511, the
RT   Blasticidin S producer.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR   EMBL; CP016279; ANP51499.1; -; Genomic_DNA.
DR   RefSeq; WP_067306047.1; NZ_JAGGLP010000005.1.
DR   STRING; 68214.AVL59_19490; -.
DR   KEGG; sgs:AVL59_19490; -.
DR   OrthoDB; 9778690at2; -.
DR   Proteomes; UP000092659; Chromosome.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR   GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR   CDD; cd08952; KR_1_SDR_x; 1.
DR   CDD; cd00833; PKS; 1.
DR   Gene3D; 3.30.70.3290; -; 2.
DR   Gene3D; 3.40.47.10; -; 2.
DR   Gene3D; 6.10.140.1830; -; 1.
DR   Gene3D; 1.10.1200.10; ACP-like; 2.
DR   Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR032821; PKS_assoc.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR041618; PKS_DE.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR   Pfam; PF00698; Acyl_transf_1; 2.
DR   Pfam; PF16197; KAsynt_C_assoc; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   Pfam; PF08659; KR; 1.
DR   Pfam; PF18369; PKS_DE; 1.
DR   Pfam; PF00550; PP-binding; 2.
DR   SMART; SM00827; PKS_AT; 2.
DR   SMART; SM00822; PKS_KR; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SMART; SM00823; PKS_PP; 2.
DR   SMART; SM01294; PKS_PP_betabranch; 1.
DR   SUPFAM; SSF47336; ACP-like; 2.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR   SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 2.
DR   SUPFAM; SSF53901; Thiolase-like; 2.
DR   PROSITE; PS50075; CARRIER; 2.
DR   PROSITE; PS00606; KS3_1; 1.
DR   PROSITE; PS52004; KS3_2; 1.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE   4: Predicted;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW   Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          661..736
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          750..1175
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          2156..2231
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
SQ   SEQUENCE   2272 AA;  239104 MW;  CF6FF0F513C70144 CRC64;
     MPPAEAALRA LENAGVVPER LRDTAAGVFS MAQADPIAAE LGVLGPALTL DTLPAGVIHL
     ACQSIRAGES ALALAGVVAP DGSGAFLVLK PVTAAVAEDD PIHCVIDGSA LGRGDVVRQA
     CARADVGHDD IRFVWRRGYH PAEAPLDGLL DGTEPGEEQD AVAALLDLPV LLGRREVPVP
     GVPLGPDSRL TALFGCVDGA GTACALVLSE PPARPRRSTR TTVPTLPVLL SADSEETLRG
     KAESLRLAGP DAPDLLDTAH TLALARRHQP HRAVLLAADR GELADGLGEL AAGRGGAGKA
     GTGRKVAFLF PGEGGQRPGM GRELYPLFDV FADALDDVCA HMEAVSTWSV RDLLLGDAPT
     EVAPADRALY TQDALFALQV ALFRQFEDWG VRPDYVVGHS VGELAAATVA GVFSLPDVCA
     LLAERIRLFR EKTPVGGAMV AMRVSEAEAL ESLAGVEHLA GISAVNAPNS VVISGDRDTV
     LRIAGVWSER GRKVKRLPVD RAFHSPHMAA MAEEFEQFAR GLSRRPPDIP LVPVHNGLGS
     DPGVVGLPEY WGAQVRGTGH FLGCVTGLHA AGVDTYVDMS TNGVLAALVE ETLPEPAAAT
     ALVTAALRGG AEQSDLHAVL GTLGELHTHG VPVRWPSVFR GWGGRRTHLP ADVAEPPSRS
     SSRPADLRRV IRTETESMIA GGYGPDRSFF ELGLDSLAAV ELVKRLRKRT GLKIATAALF
     DHPTPNRLAA HLENRTPRPV PALPRRTGTD EPIAIVGMSC RFPGGVHSPE DLWRLIVSGR
     DAISAMPEDR GWDLADLYDP ERERPGTSYV RRGGFLHDAA DFDPAFFGIG GHEALDMDPQ
     QRLLLELSWE ACERAGIDPA TLRGSDTGVY AGLSHGDYGT GPGHGDSAVR PHLAIGTVAS
     VASGRISFAF GLEGPNLSID TACSSSLVAL HLAAAALRRG ECSLALAGAV TVLSSPKVFI
     EFSRQGGLAP DARLKPFAED ADGTVWAEGG GMFLVERYSD ARRNGHPVLA LIAGSAVNSD
     GASNGLTAPN GAAQHRLLVS ALADARLQPS DVDVVEAHGT GTKLGDPIEA GALLEAYGAH
     RPPARPLLVG SVKSNLGHTQ AAAGAAGVMK MVLAMRHGVI PATLNVDRPS PHVDWDAGLR
     LVTERTAWPD AGPLRRAGVS SFGIGGTNAH VILQQPPAGA AGAAEPTKTV PPVLTVSGGS
     ETALRAQAGR LAAHWDAHAG LTAHDLGFSL ATTRSALTHR AVLTGDPDRL RHSLTALAAG
     RSDPALTVGA VAEGGLAFLL TGQGSQRLGM GRALHAAYPV FAEAFDEVCA ELGLPVKETV
     FGADQAALDR TEFAQTGLFA FEVALFRLLD SWGIRPDLLL GHSIGGLTAA HLAGVLSLPD
     ACRLVAARGS LMQALPEEGA MYAVAAAPEE VEPLPAGVSL AAVNGPRSVV LSGVEEAVVA
     LAERLRAQGR RTKRLRVSHA FHSSLMDPLL DEFRAVAESL AYQPPEIPVV SDVTGRPATA
     DELCSPEYWV RHVRGTVRFF DGMRTLQDEG VTTFLELGPE TTLTEMAADC LGETVEATVI
     PVLRQDDVLD TVAALQVRGH GPDWRLWYAG SGARRVDLPT YAFQRKRFWL LPDAVDGRSR
     QPDSAFWAAV ESHDLKLLAE LLGTSTDRKF SELVPALAQW WRTRDREAAM NGLRYRISWQ
     PAVDQVADRR NWLLVHSADL PVPEPLRAAL GDRTLPLGTG ADRAEIAERL AALANGEGGA
     VDGVLSLLAL DERERPGTAG VPAGLALTTA LVQAMGDAEL EVPLWCATQQ AVSTGHGDRL
     GSPAQAMVWG LGRVAALEHP QRWGGLIDLP ATVDARAAER LAGALSHAED QVAVRASGVF
     VRRLLHAPVG AGSSRDWPVR GTTLITGAFG ALGRRVALWL ARAGVERLLL TGRNARDPEL
     VAELTALGAE VDVAACDVGD REQVAALLAR IPEDRPLTAV AHAAGVLDDG VIDALDPQRL
     ERVLHAKVGG AAHLHELAGD LAAFVLFSSA TGAVGNAGQA NYAAANTYLD ALAEQRRADG
     LAATSVAWGP WGAGGMAVDG ADADVVGARL RRNGMTVLDP DLAIDALELA FAQDESGLVI
     ADVDWARFLS VFATTRHSPL LANLPEVQHS KEATPPEEVS SLVRRLAGMS SAERARALRD
     LVCRHAARVL GHDSSAQIRP GRPFHEQGLN SLGVVELRNQ LSTETGLRVP ANALFDHPTP
     TALAGYLDTA LAPASEEPEH TAEPESETAD LDTLLNHAEQ ELSLMLKDRV DD
//

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