ID A0A1B1B8B2_9ACTN Unreviewed; 342 AA.
AC A0A1B1B8B2;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Hydroxyacid dehydrogenase {ECO:0000313|EMBL:ANP55070.1};
GN ORFNames=AVL59_40700 {ECO:0000313|EMBL:ANP55070.1};
OS Streptomyces griseochromogenes.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=68214 {ECO:0000313|EMBL:ANP55070.1, ECO:0000313|Proteomes:UP000092659};
RN [1] {ECO:0000313|EMBL:ANP55070.1, ECO:0000313|Proteomes:UP000092659}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14511 {ECO:0000313|EMBL:ANP55070.1,
RC ECO:0000313|Proteomes:UP000092659};
RA Wu L.;
RT "Complete genome sequence of Streptomyces griseochromogenes ATCC 14511, the
RT Blasticidin S producer.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00005854,
CC ECO:0000256|RuleBase:RU003719}.
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DR EMBL; CP016279; ANP55070.1; -; Genomic_DNA.
DR RefSeq; WP_067314526.1; NZ_JAGGLP010000006.1.
DR AlphaFoldDB; A0A1B1B8B2; -.
DR STRING; 68214.AVL59_40700; -.
DR KEGG; sgs:AVL59_40700; -.
DR OrthoDB; 117809at2; -.
DR Proteomes; UP000092659; Chromosome.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd12171; 2-Hacid_dh_10; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR029753; D-isomer_DH_CS.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR42789; D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090); 1.
DR PANTHER; PTHR42789:SF1; D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090); 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003719}.
FT DOMAIN 51..341
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 131..310
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 342 AA; 36097 MW; 6E278A1D8A7559F0 CRC64;
MTSMNRPLVV AAGDHFVLPS LIASAVESQC LCEVRELTLG WPLEPFGSVA EVSEASDAED
ELIGALAGAR VLVTQMGPVT ERVLAACPEL RLVVVCRGGP VNVNLAAAKR HDVRVCFAPG
RNAAATAEFT VGLLLAALRR IPQAHELLAR RGSWAGSAYY TYEHSGLELE DLPVGLVGYG
AVGSRVARVL CAFGARVMVY DPYVRGEVHG LRLSSLDELL GRSRVITLHA RLTAETRGLI
GARELGLLPP GAVVVNAARG PLLDEDALCD ALEGGRLAAA ALDTYVREPL PADSRLHALA
DRLVLTPHLG GASRAVAEKA ARIAAAEVGR WVRGEPLAHC LT
//
