ID A0A1B1BE40_9ACTN Unreviewed; 745 AA.
AC A0A1B1BE40;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=Metallo-beta-lactamase domain-containing protein {ECO:0000259|SMART:SM00849};
GN ORFNames=AVL59_40135 {ECO:0000313|EMBL:ANP57085.1};
OS Streptomyces griseochromogenes.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=68214 {ECO:0000313|EMBL:ANP57085.1, ECO:0000313|Proteomes:UP000092659};
RN [1] {ECO:0000313|EMBL:ANP57085.1, ECO:0000313|Proteomes:UP000092659}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14511 {ECO:0000313|EMBL:ANP57085.1,
RC ECO:0000313|Proteomes:UP000092659};
RA Wu L.;
RT "Complete genome sequence of Streptomyces griseochromogenes ATCC 14511, the
RT Blasticidin S producer.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP016279; ANP57085.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1B1BE40; -.
DR STRING; 68214.AVL59_40135; -.
DR KEGG; sgs:AVL59_40135; -.
DR Proteomes; UP000092659; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR NCBIfam; TIGR00360; ComEC_N-term; 1.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 196..217
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 229..250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 256..272
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 303..321
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 333..354
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 428..446
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 453..471
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 494..672
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
FT REGION 68..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 605..626
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..91
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 605..619
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 745 AA; 76981 MW; 5B25C5664E87F785 CRC64;
MPELARRFAT VTAEVELTGD PWLSRPRVRG DHAAPIAVLA RAEVLRVEEG DGAGVRTRSP
VLVVVDADVP GPRAPPTADA SAAPAPPGPR GARPAWLGLL PSTRLRVHAR LAPALTGGDR
TAAVLRVRSE PAPQVVAGPS GPQRLAGRLR NGLRKATDGL PGDARALLPG LVVGDTSRIT
PELDEAFRET DLTHTLAVSG SNLTILLALL IGPPGLAQRV ERRGLAPRLG LSLRTTALLA
GALTLGFVIV CRPDPSVLRA AACGTVALLA LATGRRRSLI PALATAVLVL VLYDPWLARS
YGFLLSVLAT GALLVLAPRW SEALRRRRVP ARFAEALAAA AAAQAVCAPV VAVLSARVSL
VAVPCNLLAE VAVAPATVLG FGALATAQVA MPVAKMLAWG ASWPAAWIAR VARTGAALPG
GGVDWPGSWA GALLLAAVTV AVVLAGRRLL RHPWLSGVLG VLLLLAVVRP VPLTRVITGW
PPPGWRFAMC DVGQGDATVL AAGEGAGVVV DAGPDPALVD HCLRELGITR IPLVVLTHFH
ADHVAGLPGV LRGRSVAAIE TTDFEEPADQ AEFVRKEAAE RHIPLTRAAA GEERRTGALA
WQVLWPPAAP PPSQGPTPEP DGPNDASVAL LVRSAGLRLL LLGDLEPPAQ QELLRSPLAA
ELAGVDVLKV AHHGSAYQDP DLIRLAAPRV ALISCGADNP YGHPAPATVA ALRAGGAMVL
RTDRDGALAV GGTGGARGEV RVARE
//
